In situ hydrothermal transformation of titanium surface into lithium-doped continuous nanowire network towards augmented bioactivity

Abdal‐hay, Abdalla; Gulati, Karan; Fernandez-Medina, Tulio; Qian, Ma; Ivanovski, Sašo

doi:10.1016/j.apsusc.2019.144604

Cited by 19 publications

(22 citation statements)

References 78 publications

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“…Indeed, the surface polarity of the Na 2 TiO 3 gel layer formed on the Ti is higher than the untreated Ti surfaces, where the surface comprises an inert amorphous titanium dioxide film. The conversion of the Na 2 TiO 3 gel layer to titanium-hydroxide (Ti-OH) after contact with an aqueous environment (such as water vapor) has been reported in our previous work [ 39 ], showing that this type of reaction is thermodynamically reasonable. The presence of OH on a treated Ti substrate may confer interesting properties to the Ti surface.…”

Section: Resultsmentioning

confidence: 92%

“…The sample preparation included grinding, polishing, and cleaning, according to previous publications [ 10 , 34 , 35 , 36 , 37 , 38 ]. Untreated samples were then etched in H 2 SO 4 :HCl:H 2 O = 1:1:1 volume ratio at 60 °C for 1 h to increase the surface roughness [ 39 ]. The hydrophilicity was enhanced by subjecting the etched samples to alkaline treatment using the same procedures as described elsewhere [ 35 , 36 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

“…Untreated samples were then etched in H 2 SO 4 :HCl:H 2 O = 1:1:1 volume ratio at 60 °C for 1 h to increase the surface roughness [ 39 ]. The hydrophilicity was enhanced by subjecting the etched samples to alkaline treatment using the same procedures as described elsewhere [ 35 , 36 , 39 ]. Briefly, the samples were immersed in 100 mL of an aqueous solution of 5 M NaOH at 60 °C for one day.…”

Section: Methodsmentioning

confidence: 99%

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Alkali-Treated Titanium Coated with a Polyurethane, Magnesium and Hydroxyapatite Composite for Bone Tissue Engineering

et al. 2021

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The aim of this study was to form a functional layer on the surface of titanium (Ti) implants to enhance their bioactivity. Layers of polyurethane (PU), containing hydroxyapatite (HAp) nanoparticles (NPs) and magnesium (Mg) particles, were deposited on alkali-treated Ti surfaces using a cost-effective dip-coating approach. The coatings were assessed in terms of morphology, chemical composition, adhesion strength, interfacial bonding, and thermal properties. Additionally, cell response to the variably coated Ti substrates was investigated using MC3T3-E1 osteoblast-like cells, including assessment of cell adhesion, cell proliferation, and osteogenic activity through an alkaline phosphatase (ALP) assay. The results showed that the incorporation of HAp NPs enhanced the interfacial bonding between the coating and the alkali-treated Ti surface. Furthermore, the presence of Mg and HAp particles enhanced the surface charge properties as well as cell attachment, proliferation, and differentiation. Our results suggest that the deposition of a bioactive composite layer containing Mg and HAp particles on Ti implants may have the potential to induce bone formation.

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Section: Resultsmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Alkali-Treated Titanium Coated with a Polyurethane, Magnesium and Hydroxyapatite Composite for Bone Tissue Engineering

et al. 2021

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“…The incorporation of metal ions, such as zinc [34], magnesium [35] and Li [36], into Ti surfaces enhances various cellular activities in osteoblasts and fibroblasts [37,38]. Our group recently reported the utilisation of hydrothermal transformation to fabricate Li-doped Ti with sustainable Li+ ions release [39]. Lithium belongs to the alkali metal group and is considered a biologically functional ion.…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that Li ions can stimulate bone growth and periodontal ligament cell differentiation through the Wnt/β-catenin signalling pathway [40,41]. Abdal-hay et al [39] investigated the influence of different LiCl concentrations on surface properties of doped Li-Ti. Their results show that a Li-Ti porous layer with nanostructure characteristics was nucleated and formed on the Ti surface.…”

Section: Introductionmentioning

confidence: 99%

Influence of Bioinspired Lithium-Doped Titanium Implants on Gingival Fibroblast Bioactivity and Biofilm Adhesion

et al. 2021

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Soft tissue integration (STI) at the transmucosal level around dental implants is crucial for the long-term success of dental implants. Surface modification of titanium dental implants could be an effective way to enhance peri-implant STI. The present study aimed to investigate the effect of bioinspired lithium (Li)-doped Ti surface on the behaviour of human gingival fibroblasts (HGFs) and oral biofilm in vitro. HGFs were cultured on various Ti surfaces—Li-doped Ti (Li_Ti), NaOH_Ti and micro-rough Ti (Control_Ti)—and were evaluated for viability, adhesion, extracellular matrix protein expression and cytokine secretion. Furthermore, single species bacteria (Staphylococcus aureus) and multi-species oral biofilms from saliva were cultured on each surface and assessed for viability and metabolic activity. The results show that both Li_Ti and NaOH_Ti significantly increased the proliferation of HGFs compared to the control. Fibroblast growth factor-2 (FGF-2) mRNA levels were significantly increased on Li_Ti and NaOH_Ti at day 7. Moreover, Li_Ti upregulated COL-I and fibronectin gene expression compared to the NaOH_Ti. A significant decrease in bacterial metabolic activity was detected for both the Li_Ti and NaOH_Ti surfaces. Together, these results suggest that bioinspired Li-doped Ti promotes HGF bioactivity while suppressing bacterial adhesion and growth. This is of clinical importance regarding STI improvement during the maintenance phase of the dental implant treatment.

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Hydrothermal growth of biomimetic calcium phosphate network structure on titanium surface for biomedical application

Zhang

Duan

et al. 2023

Ceramics International

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In situ hydrothermal transformation of titanium surface into lithium-doped continuous nanowire network towards augmented bioactivity

Cited by 19 publications

References 78 publications

Alkali-Treated Titanium Coated with a Polyurethane, Magnesium and Hydroxyapatite Composite for Bone Tissue Engineering

Alkali-Treated Titanium Coated with a Polyurethane, Magnesium and Hydroxyapatite Composite for Bone Tissue Engineering

Influence of Bioinspired Lithium-Doped Titanium Implants on Gingival Fibroblast Bioactivity and Biofilm Adhesion

Hydrothermal growth of biomimetic calcium phosphate network structure on titanium surface for biomedical application

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