In Situ Imaging and Anti-inflammation of 3D Printed Scaffolds Enabled by AIEgen

Wang, Xiaoxuan; Chen, Pu; He, Yi; Liu, Jiawei; Tu, Rong; Feng, Hai-Tao; Dai, Hongyue

doi:10.1021/acsami.3c03082

ACS Appl. Mater. Interfaces

2023

DOI: 10.1021/acsami.3c03082

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In Situ Imaging and Anti-inflammation of 3D Printed Scaffolds Enabled by AIEgen

Xiaoxuan Wang

Pu Chen

Yi He

et al.

Abstract: Three-dimensional (3D) printed bioactive scaffolds have been widely used in the field of bone tissue engineering. However, its in vivo visualization and bacterial inflammation are intractable issues during the surgery and treatment. Herein, we first synthesized an aggregation-induced emission-active luminogen (AIEgen) named 4BC with efficient reactive oxygen species (ROS) generation. Then, a series of 3D bioactive scaffolds loaded with 4BC were fabricated by a precipitation adsorption method, namely 4BC@scaffo… Show more

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Cited by 7 publications

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Aggregation‐induced emission biomarkers for early detection of orthopaedic implant failure

Tavakoli,

Hu,

Tipper

et al. 2024

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In recent years, the substantial increase in total joint replacements for treating degenerative joint disease has heightened concerns regarding implant loosening and failure. This is especially critical as more young patients are undergoing both initial and subsequent joint replacement procedures. These complications often necessitate additional revision surgeries. Unfortunately, current clinical practices lack effective methods for the early detection of implant failure, and there is a noticeable absence of strategies utilizing molecular markers to identify post‐surgery implant issues. This article critically assesses the potential of aggregation‐induced emission (AIE) biomarkers in detecting molecular markers relevant to implant failure. It begins by outlining the pathogenesis of implant loosening and identifying pertinent molecular markers. The study then delves into how AIE luminogens (AIEgens) can play a crucial role in detecting processes such as osteogenesis and osteoclastogenesis. Notably, it discusses the utilization of AIEgens in detecting key molecular markers, including TNF‐α, osteocalcin, and urinary N‐terminal telopeptide. The prospect of AIE biomarkers for the early detection of bone loss and implant failure presents a promising avenue for enhancing our understanding of skeletal health and improving clinical outcomes through timely intervention and personalized treatment approaches. Ongoing research and development in this area are crucial for translating AIE‐based technologies into practical tools for optimizing bone health management.

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Aggregation‐induced emission biomarkers for early detection of orthopaedic implant failure

Tavakoli,

Hu,

Tipper

et al. 2024

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Wide‐Spectrum Nano‐Antibiotics Based on TPA‐Py@AuNCs⊂BSA for Multimodal Synergistic Therapy of Drug‐Resistant Bacteria and Wound Infections

Xu,

Zhang,

Zhang

et al. 2024

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To meet the high requirements of biomedical applications in antimicrobial agents, it is crucial to explore efficient nano‐antimicrobial agents with no resistance and good biocompatibility for treating infected wounds. In this study, composite nano‐antibiotic TPA‐Py@AuNCs⊂BSA nanoparticles (TAB NPs) are prepared using hollow mesoporous Au nanocages (AuNCs) loaded with a photosensitizer (namely TPA‐Py) with D‐π‐A structure showing aggregation‐induced emission properties. When TPA‐Py is encapsulated in the cavity of AuNCs, its fluorescence is suppressed. In the presence of photothermal induction, TPA‐Py can be released from the AuNCs, allowing for the restoration of fluorescence illumination and the specific imaging of Gram‐positive bacteria. TAB NPs demonstrate outstanding antimicrobial activity against a variety of bacteria, and this multimodal antimicrobial property does not lead to the development of bacterial resistance. In vitro experiments show that TAB NPs could eliminate bacteria and ablate bacterial biofilm. In vivo experiments show that the synergistic antimicrobial effect of TAB NPs has a significant positive impact on the treatment of infected wounds, including rapid antibacterial action, promotion of M2 macrophage polarization, and enhancement of chronic wound healing. This study provides an effective strategy for developing wide‐spectrum nano‐antibiotics for the ablation of bacterial biofilms and the treatment of infected wounds.

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Emerging advances in fluorescence imaging and phototherapy of arthritis

Wang,

Dai,

Shao

et al. 2023

Interdisciplinary Materials

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Arthritis is a chronic disease whose etiology is difficult to pinpoint, and the difficulty of arthritis detection and subsequent treatment causes enormous distress to patients. In recent years, thanks to advances in medicine and detection, a variety of treatment modalities for arthritis have emerged. The combination of emerging detection technologies with different anti‐inflammatory medications and even advances in surgical techniques have all played a positive role in the treatment of arthritis. In the present work, we have collected relevant literature on fluorescence (FL) imaging and phototherapy of arthritis in recent years, intending to reveal the advantages and potential application value of FL imaging and phototherapy for researchers. Meanwhile, due to the shortcomings of FL imaging and phototherapy in the diagnosis and treatment of arthritis, we advocate overcoming these difficulties in future research.

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In Situ Imaging and Anti-inflammation of 3D Printed Scaffolds Enabled by AIEgen

Cited by 7 publications

References 62 publications

Aggregation‐induced emission biomarkers for early detection of orthopaedic implant failure

Aggregation‐induced emission biomarkers for early detection of orthopaedic implant failure

Wide‐Spectrum Nano‐Antibiotics Based on TPA‐Py@AuNCs⊂BSA for Multimodal Synergistic Therapy of Drug‐Resistant Bacteria and Wound Infections

Emerging advances in fluorescence imaging and phototherapy of arthritis

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