In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography

Cernohorsky, Paul; Bruin, Daniël M. de; Herk, Marcel van; Bras, Johannes; Faber, Dirk J.; Strackee, Simon D.; Leeuwen, Ton G. van

doi:10.1117/1.jbo.17.6.060501

Cited by 17 publications

(22 citation statements)

References 18 publications

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“…For the ACLT and C-L measurements, sample thicknesses were estimated using a high resolution ultrasound system (Huang and Zheng, 2009;Toyras et al, 2003) (Clear View Ultra, Boston Scientific Corporation, San Jose, CA, USA). For the CTRL samples, thicknesses were estimated using optical coherence tomography (OCT) (Ilumien PCI Optimization System, St. Jude Medical, St. Paul, MN, USA) (Cernohorsky et al, 2012;te Moller et al, 2013). The initially approximated thicknesses were later confirmed by microscopy and corrected for modeling if necessary.…”

Section: Lat Med Lat Medmentioning

confidence: 99%

Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage

Mäkelä

Han

Herzog

et al. 2015

Journal of Biomechanics

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In this study, fibril-reinforced poroelastic (FRPE) modeling was used for rabbit knee after anterior cruciate ligament transection (ACLT) to assess how the mechanical properties of collagen, proteoglycans, and fluid in articular cartilage change in early osteoarthritis, and how site-specific these changes are. Unilateral ACLT was performed in eight skeletally mature, female New Zealand white rabbits. A separate control (CTRL) group consisted of knee joints of five non-operated rabbits. Animals were sacrificed at four weeks after ACLT and cartilage-on-bone samples from femoral groove, medial and lateral femoral condyles, and tibial plateaus were harvested. A stress-relaxation protocol in indentation geometry was applied and the FRPE model was fitted to the experimental force-time curve by minimizing the mean absolute error between experiment and simulation. The optimized parameters were: fibril network modulus (Ef), representing the collagen network; non-fibrillar matrix modulus (Enf), representing the PG matrix; and permeability (k), representing fluid flow. Permeability was increased significantly in the ACLT group compared to the CTRL group knees at all sites except for the medial tibial plateau. ACLT also caused a decrease in the Ef at all sites except for the medial and lateral tibial plateaus. The Enf of the ACLT group knees was altered only for the lateral femoral condyle. The results of this study suggest that early osteoarthritis primarily affects cartilage permeability and impairs the collagen network stiffness in a site-specific manner. These findings from early osteoarthritis indicate that fluid flow velocity in articular cartilage may change prior to quantifiable structural alterations in the tissue.

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Section: Lat Med Lat Medmentioning

confidence: 99%

Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage

Mäkelä

Han

Herzog

et al. 2015

Journal of Biomechanics

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“…Optical coherence tomography (OCT) can detect damage to articular cartilage ( Chu et al 2010 ; Cernohorsky et al 2012 ), and at an earlier stage compared to macroscopic evaluation during arthroscopy ( Chu et al 2004 , Zheng et al 2010 ). OCT is analogous to ultrasound, but uses near-infrared light rather than sound to produce high-resolution, cross-sectional images with limited depth penetration (typically up to 2 mm).…”

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confidence: 99%

Comparison of optical coherence tomography and histopathology in quantitative assessment of goat talus articular cartilage

Cernohorsky¹,

Ac²,

Dm³

et al. 2014

Acta Orthopaedica

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Background and purpose Optical coherence tomography (OCT) is a light-based imaging technique suitable for depiction of thin tissue layers such as articular cartilage. Quantification of results and direct comparison with a reference standard is needed to confirm the role of OCT in cartilage evaluation.Materials and methods Goat talus articular cartilage repair was assessed quantitatively with OCT and compared with histopathology using semi-automated analysis software. Osteochondral defects were created centrally in goat tali with subsequent healing over 24 weeks. After sacrifice, the tali were analyzed using OCT and processed into histopathology slides. Cartilage thickness, repair tissue area, and surface roughness were measured. Also, light attenuation coefficient measurements were performed to assess differences in the properties of healthy tissue and repair tissue.Results Intra-class correlation coefficients for resemblance between the 2 techniques were 0.95 (p < 0.001) for thickness, 0.73 (p = 0.002) for repair tissue area, and 0.63 (p = 0.015) for surface roughness. Light attenuation differed significantly between healthy cartilage (8.2 (SD 3.9) mm-1) and repair tissue (2.8 (SD 1.5) mm-1) (p < 0.001).Interpretation Compared to histopathology as the standard reference method, OCT is a reproducible technique in quantitative analysis of goat talus articular cartilage, especially when assessing cartilage thickness and to a lesser extent when measuring repair tissue area and surface roughness. Moreover, differences in local light attenuation suggest measurable variation in tissue structure, enhancing the clinical applicability of quantitative measurements from cartilage OCT images.

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“…17,18 Cylindrical catheters with single rotating optical fibers are capable of scanning the esophageal wall surface over a length of 6 cm. [19][20][21][22][23][24] A probe-based OCT imaging session can be combined with a standard WLE procedure for minimally invasive diagnosis. More recently, a tethered capsule endomicroscopy technique was integrated in a pill-like imaging device meant for voluntary swallowing, which is capable of cross-sectional OCT imaging of the whole esophagus without sedation and minimal burden to patients.…”

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Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models

et al. 2018

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"Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models," J. Biomed. Opt. 23(4), 046004 (2018), doi: 10.1117/1.JBO.23.4.046004. Abstract. Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10 μm) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose delivery of 4.0, 10.0, 16.0, and 20.0 Gy on 5.0-mm spots, spaced 10.0 mm apart in the esophagus. They were repeatedly imaged using OCT up to three months postirradiation. We compared OCT findings with histopathology obtained three months postirradiation qualitatively and quantitatively using the contrast-to-background-noise ratio (CNR). Histopathology mostly showed inflammatory infiltration and edema at higher doses; OCT findings were in agreement with most of the histopathological reports. We were able to identify the ARIED on OCT as a change in tissue scattering and layer thickness. Our statistical analysis showed significant difference between the CNR values of healthy tissue, edema, and inflammatory infiltration. Overall, the average CNR for inflammatory infiltration and edema damages was 1.6-fold higher and 1.6-fold lower than for the healthy esophageal wall, respectively. Our results showed the potential role of OCT to detect and monitor the ARIED in mice, which may translate to humans. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography

Cited by 17 publications

References 18 publications

Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage

Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage

Comparison of optical coherence tomography and histopathology in quantitative assessment of goat talus articular cartilage

Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models

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