In Situ Liquid Crystal Gel as a Promising Strategy for Improving Ocular Administration of Dexamethasone: Preparation, Characterization, and Evaluation

Wu, Wenqing; Cao, Weiguo; Chen, Jingbao; Cai, Ye; Dong, Baoqi; Chu, Xiaoqin

doi:10.1208/s12249-021-02193-6

Cited by 7 publications

(2 citation statements)

References 47 publications

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“…Among corticosteroids used for the treatment of eye diseases, DEX has been considered as the most powerful. 30 This corticosteroid agent could be applied as a topical formulation, intravitreal injection, or implant. For topical formulations of DEX, ophthalmic solutions or suspensions could be prepared for different purposes.…”

Section: Dexamethasone For Eye Diseases’ Therapymentioning

confidence: 99%

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Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems

Madamsetty

Mohammadinejad

Uzielienè

et al. 2022

ACS Biomater. Sci. Eng.

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Dexamethasone (DEX) has been widely used to treat a variety of diseases, including autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19. However, DEX usage is often restricted in the clinic due to its poor water solubility. When administered through a systemic route, it can elicit severe side effects, such as hypertension, peptic ulcers, hyperglycemia, and hydro-electrolytic disorders. There is currently much interest in developing efficient DEX-loaded nanoformulations that ameliorate adverse disease effects inhibiting advancements in scientific research. Various nanoparticles have been developed to selectively deliver drugs without destroying healthy cells or organs in recent years. In the present review, we have summarized some of the most attractive applications of DEX-loaded delivery systems, including liposomes, polymers, hydrogels, nanofibers, silica, calcium phosphate, and hydroxyapatite. This review provides our readers with a broad spectrum of nanomedicine approaches to deliver DEX safely.

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Section: Dexamethasone For Eye Diseases’ Therapymentioning

confidence: 99%

“…These applications make corticosteroids a key therapeutic agent in various eye diseases. Among corticosteroids used for the treatment of eye diseases, DEX has been considered as the most powerful . This corticosteroid agent could be applied as a topical formulation, intravitreal injection, or implant.…”

Section: Dexamethasone For Eye Diseases’ Therapymentioning

confidence: 99%