In situ localization of tris(2,3-dibromopropyl) isocyanurate in mouse organs by MALDI-IMS with auxiliary matrix strategy

Tong, Yi; Guo, Cheng; Liu, Zhengzheng; Shi, Keqiang; Zhang, Haiyan; Liu, Yaqin; Wu, Kuan-Lu; Feng, Hongru; Pan, Yuanjiang

doi:10.1016/j.talanta.2021.122723

Cited by 8 publications

(7 citation statements)

References 36 publications

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“…Modifications of the methods were also related to the ways of identification of TBC in living organisms. In their study on the presence and distribution of the tested compound in mouse organs (liver, kidney, heart, and brain) administered at 160 mg/kg/day for 30 days, Tong et al, ( 2021 ) proved the effectiveness of matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) on the matrix of 1,5-diaminonaphthalene hydrochloride and silver trifluoromethanesulfonate (NDA/AgOTf). The detection limit of the method was of the order of μg/mL (Tong et al, 2021 ).…”

Section: Methods For Tbc Identificationmentioning

confidence: 99%

Comprehensive review of the impact of tris(2,3-dibromopropyl) isocyanurate (TBC or TDBP-TAZTO) on living organisms and the environment

Bar

Szychowski

2022

Environ Geochem Health

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Tris(2,3-dibromopropyl) isocyanurate (TBC or TDBP-TAZTO) belongs to the group of brominated flame retardants (BFRs). The production of this compound is increasing due to the growing demand and wide application in electrical, electronic, musical instrument, and automotive component industries. The properties of TBC, e.g., the high octanol–air partition coefficient (Koa), high octanol–water partition coefficient (Kow), and high bioconcentration factor (BCF), indicate a possibility of its spread in aquatic and terrestrial ecosystems and bioaccumulation in living organisms. The presence of TBC has been confirmed in soil, sediments, river water, and such materials as microplastic, curtains, and e-waste devices. The compound has potential to bioaccumulate in the food chain of living organisms. TBC has been demonstrated to exert a harmful effect mainly on the nervous and endocrine systems, lungs, and liver. The possible mechanism of toxicity of the compound in the nervous system is based on the generation of oxidative stress by TBC leading to apoptosis of neuronal cells, while mitochondrial damage is considered to be responsible for changes in the respiratory organ. Moreover, the potential of mussels and earthworms to be bioindicators of TBC has been proven. Therefore, the literature review is focused on TBC properties and analysis of the identification and impact of the compound on the environment, living organisms, and human cell lines. Given the many toxic effects of TBC highlighted in the literature, there is a need for more profound research on the safety of TBC and methods for identification and degradation of this compound.

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Section: Methods For Tbc Identificationmentioning

confidence: 99%

Comprehensive review of the impact of tris(2,3-dibromopropyl) isocyanurate (TBC or TDBP-TAZTO) on living organisms and the environment

Bar

Szychowski

2022

Environ Geochem Health

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“…Research on the use of MALDI to measure biomolecules dates back to the 1990s [13] and was awarded the Nobel Prize in 2002. Over the next 30 years, a number of variants of the technique were developed, and they are used in various biochemical analyses [14][15][16]. With the development of laser desorption-based mass spectrometry, researchers have found that the use of microarray biochips can effectively target and detect biomolecules, including DNA, RNA, peptides, sugars, proteins, etc.…”

Section: Biochip and Mass Tag-based Mass Spectrometry Sensing Technologymentioning

confidence: 99%

“…This device cauterizes biological tissue (e.g., tumor margins) by heating the tip and continuously collects a plume for chemical information acquisition [72]. Balog et al used this technique to analyze various tissue samples from over 300 patients, reflecting the lipidomic profile among different histological tumor types and between primary and metastatic tumors [14]. Golf et al constructed the REIMS imaging platform for differentiating healthy/cancerous tissues and different bacterial/Fungi strains and built a spectral library [73][74][75].…”

Section: Pen/knife-like Mass Spectrometry Sensing Technologymentioning

confidence: 99%

Mass Spectrometry-Based Biosensing and Biopsy Technology

et al. 2023

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Sensitive and accurate detection of biomolecules by multiplexed methods is important for disease diagnosis, drug research, and biochemical analysis. Mass spectrometry has the advantages of high sensitivity, high throughput, and high resolution, making it ideal for biomolecular sensing. As a result of the development of atmospheric pressure mass spectrometry, researchers have been able to use a variety of means to identify target biomolecules and recognize the converted signals by mass spectrometry. In this review, three main approaches and tools are summarized for mass spectrometry sensing and biopsy techniques, including array biosensing, probe/pen-based mass spectrometry, and other biosensor–mass spectrometry coupling techniques. Portability and practicality of relevant mass spectrometry sensing methods are reviewed, together with possible future directions to promote the advancement of mass spectrometry for target identification of biomolecules and rapid detection of real biological samples.

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“…Nanomaterials cannot be used due to some disadvantages such as long preparation cycle, high cost, and low applicability in MS 21,22 . In recent years, the development of new organic matrices based on conventional matrices has attracted much attention 23 . The most classical matrix design involves the combination of conventional and organic matrices, which can be traced back to the advent of ionic liquids 24 .…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19][20] Nanomaterials cannot be used due to some disadvantages such as long preparation cycle, high cost, and low applicability in MS. 21,22 In recent years, the development of new organic matrices based on conventional matrices has attracted much attention. 23 The most classical matrix design involves the combination of conventional and organic matrices, which can be traced back to the advent of ionic liquids. 24 And it is generally believed that organic bases with heterocyclic and heteroatomic structures such as pyridine and aniline have an impact on the ionization efficiency and laser absorption effect, which may make it more suitable in MALDI-MS. 25,26 In this study, we designed and developed a novel matrix α-cyano-4-hydroxycinnamic acid/p-phenylenediamine (CHCA/PPD) using a simple method for MALDI-MSI analysis of antibiotics (quinolones and sulfonamides).…”

Section: Introductionmentioning

confidence: 99%

Developing CHCA/PPD as a novel matrix for enhanced matrix‐assisted laser desorption/ionization‐mass spectrometry imaging for analysis of antibiotics in grass carp tissues

Qiu

Chen

Liu

et al. 2022

Rapid Comm Mass Spectrometry

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Antibiotics have important medical value, but they need to be monitored when used as veterinary drugs. We report α‐cyano‐4‐hydroxycinnamic acid/p‐phenylenediamine (CHCA/PPD) hybrid as a novel matrix for enhanced matrix‐assisted laser desorption/ionization‐mass spectrometry imaging (MALDI‐MSI) in situ the spatial distribution of antibiotic drugs in grass carp tissues. Method We have used MALDI‐TOF‐MSI in positive ion mode for the analysis of quinolones and sulfonamides in grass carps. A novel CHCA/PPD matrix was prepared and applied using a simple method to improve the analysis. Results Compared with the traditional matrix, CHCA/PPD significantly improved the detection intensity of quinolones and sulfonamides with better sensitivity (17.20%–94.30%) and reproducibility. For demonstration, this novel matrix was successfully applied to visualize enrofloxacin (ENR) in grass carp tissues, with the entire abundance differences clearly observed based on MALDI‐MSI. The concentration levels in different tissues were determined, with a calibration curve of 10–2000 μg/ml (R2 > 0.993). Conclusion This study was the first to introduce CHCA/PPD as a novel matrix, and the classical acid–base mixing was used to improve the ionization effect of the traditional matrix CHCA in MALDI. Based on CHCA/PPD, MALDI‐MSI detected ENR in different grass carp tissues for the first time and realized the spatial distribution and concentration detection.

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In situ localization of tris(2,3-dibromopropyl) isocyanurate in mouse organs by MALDI-IMS with auxiliary matrix strategy

Cited by 8 publications

References 36 publications

Comprehensive review of the impact of tris(2,3-dibromopropyl) isocyanurate (TBC or TDBP-TAZTO) on living organisms and the environment

Comprehensive review of the impact of tris(2,3-dibromopropyl) isocyanurate (TBC or TDBP-TAZTO) on living organisms and the environment

Mass Spectrometry-Based Biosensing and Biopsy Technology

Developing CHCA/PPD as a novel matrix for enhanced matrix‐assisted laser desorption/ionization‐mass spectrometry imaging for analysis of antibiotics in grass carp tissues

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