In-situ monitoring of an organic sample with electric field determination during cold plasma jet exposure

Slikboer, Elmar; Sobota, Ana; García-Caurel, Enric; Guaitella, Olivier

doi:10.1038/s41598-020-70452-w

Cited by 17 publications

(13 citation statements)

References 40 publications

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“…The quantification of surface charging by the IWs generated by the plasma jet is done using an advanced novel diagnostic called Mueller polarimetry. A similar setup has been used in previous works 33 , 48 – 50 but the experimental procedure taken in this work, shown in Fig. 6 , followed the configuration proposed in 34 , 35 .…”

Section: Methodsmentioning

confidence: 99%

Quantification of surface charging memory effect in ionization wave dynamics

Viegas

Slikboer

Bonaventura

et al. 2022

Sci Rep

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The dynamics of ionization waves (IWs) in atmospheric pressure discharges is fundamentally determined by the electric polarity (positive or negative) at which they are generated and by the presence of memory effects, i.e. leftover charges and reactive species that influence subsequent IWs. This work examines and compares positive and negative IWs in pulsed plasma jets (1 $$\upmu $$ μ s on-time), showing the difference in their nature and the different resulting interaction with a dielectric BSO target. For the first time, it is shown that a surface charging memory effect is produced, i.e. that a significant amount of surface charges and electric field remain in the target in between discharge pulses (200 $$\upmu $$ μ s off-time). This memory effect directly impacts IW dynamics and is especially important when using negative electric polarity. The results suggest that the remainder of surface charges is due to the lack of charged particles in the plasma near the target, which avoids a full neutralization of the target. This demonstration and the quantification of the memory effect are possible for the first time by using an unique approach, assessing the electric field inside a dielectric material through the combination of an advanced experimental technique called Mueller polarimetry and state-of-the-art numerical simulations.

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Section: Methodsmentioning

confidence: 99%

Quantification of surface charging memory effect in ionization wave dynamics

Viegas

Slikboer

Bonaventura

et al. 2022

Sci Rep

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“…The latter was of most importance since it relates directly to the imposed electric field inside the sample due to surface charges as a result of the plasma–surface interaction. Depolarization can be an interesting tool as well since it allows to look at the surface changes a material undergoes during plasma exposure 36 . Example images of the Mueller matrices and logarithmic decomposed matrices can be found in Ref.…”

Section: Methodsmentioning

confidence: 99%

Towards plasma jet controlled charging of a dielectric target at grounded, biased, and floating potential

Slikboer

Guaitella

García-Caurel

et al. 2022

Sci Rep

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Electric field and surface charge measurements are presented to understand the dynamics in the plasma–surface interaction of a plasma jet and a dielectric surface. The ITO coated backside of the dielectric allowed to impose a DC bias and thus compare the influence of a grounded, biased and floating potential. When imposing a controlled potential at the back of the target, the periodical charging is directly dependent on the pulse length, irrespective of that control potential. This is because the plasma plume is sustained throughout the pulse. When uncontrolled and thus with a floating potential surface, charge accumulation and potential build-up prevents a sustained plasma plume. An imposed DC bias also leads to a continuous surface charge to be present accumulated on the plasma side to counteract the bias. This can lead to much higher electric fields (55 kV/cm) and surface charge (200 nC/cm$$^2$$ 2 ) than observed previously. When the plasma jet is turned off, the continuous surface charge decreased to half its value in 25 ms. These results have implications for surface treatment applications.

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“…Another important reason for the stronger anti-tumor effect of direct CAP treatment could be physical. Next to RONS production, CAP also generates thermal-and ultraviolet (UV) radiation, which also have a strong impact on tumor cell behavior [54][55][56], and which are not available in the case of indirect treatment with PTS.…”

Section: Discussionmentioning

confidence: 99%

Cold Atmospheric Plasma Changes the Amino Acid Composition of Solutions and Influences the Anti-Tumor Effect on Melanoma Cells

Arndt

Fadil

Dettmer

et al. 2021

IJMS

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Cold Atmospheric Plasma (CAP) is an ionized gas near room temperature. Its anti-tumor effect can be transmitted either by direct treatment or mediated by a plasma-treated solution (PTS), such as treated standard cell culture medium, which contains different amino acids, inorganic salts, vitamins and other substances. Despite extensive research, the active components in PTS and its molecular or cellular mechanisms are not yet fully understood. The purpose of this study was the measurement of the reactive species in PTS and their effect on tumor cells using different plasma modes and treatment durations. The PTS analysis yielded mode- and dose-dependent differences in the production of reactive oxygen and nitrogen species (RONS), and in the decomposition and modification of the amino acids Tyrosine (Tyr) and Tryptophan (Trp). The Trp metabolites Formylkynurenine (FKyn) and Kynurenine (Kyn) were produced in PTS with the 4 kHz (oxygen) mode, inducing apoptosis in Mel Im melanoma cells. Nitrated derivatives of Trp and Tyr were formed in the 8 kHz (nitrogen) mode, elevating the p16 mRNA expression and senescence-associated ß-Galactosidase staining. In conclusion, the plasma mode has a strong impact on the composition of the active components in PTS and affects its anti-tumor mechanism. These findings are of decisive importance for the development of plasma devices and the effectiveness of tumor treatment.

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In-situ monitoring of an organic sample with electric field determination during cold plasma jet exposure

Cited by 17 publications

References 40 publications

Quantification of surface charging memory effect in ionization wave dynamics

Quantification of surface charging memory effect in ionization wave dynamics

Towards plasma jet controlled charging of a dielectric target at grounded, biased, and floating potential

Cold Atmospheric Plasma Changes the Amino Acid Composition of Solutions and Influences the Anti-Tumor Effect on Melanoma Cells

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