Shaped sweeping jet (SSJ) holes represent an advancement in sweeping jet (SJ) technology, as they offer enhanced cooling performance. To reveal the anti-deposition capabilities of SSJs, particle deposition results of 777-shaped and SSJ holes were compared through a combination of experiments and numerical simulations. Three-dimensional (3D) deposition topography was measured through the multi-perspective scanning (MPS) method across various blowing ratios (M = 0.5, 1.0, 1.5, and 2.0). The findings revealed that SSJ holes exhibited superior anti-deposition performance across a range of blowing ratios, resulting in a 5%–14% reduction in deposition roughness compared with the 777-shaped holes. To improve the precision of particle deposition simulations, a novel deposition-and-removal model incorporating an unsteady simulation strategy was developed and quantitatively validated against experimental results. Computational analyses revealed that the remarkable anti-deposition performance of SSJ holes was due to the formation of unique vortex structures, distinct from the counter-rotating vortex pair, and the increased level of periodic oscillation-induced wall shear stress near the hole exit. These findings underscore the potential of SSJ technology in film cooling applications to mitigate deposition concerns.