In Situ Oxidation of Cu2O Crystal for Electrochemical Detection of Glucose

Lu, Chenlin; Li, Zhipeng; Ren, Ling; Su, Nan; Lu, Diannan; Liu, Zheng

doi:10.3390/s19132926

Cited by 46 publications

(25 citation statements)

References 62 publications

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“…The positive potential shift indicates a slow electron transfer process, while the linear fit of the anodic and cathodic peak currents implies a surface diffusion-limited process [36] due to porous electrode surface as confirmed in SEM image in Figure 2b. This is in line with other literature reports for Cu 2 O/CuO-based glucose electrocatalysis in alkaline media [37,38]. The mechanism of glucose oxidation on cuprite is not fully understood, but it is assumed that the CuOOH oxidant reagent is responsible for the glucose oxidation into gluconolactone [29,39].…”

Section: Cu 2 O Nanocluster Study On Gcesupporting

confidence: 91%

Cu2O-Based Electrochemical Biosensor for Non-Invasive and Portable Glucose Detection

2022

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Electrochemical voltammetric sensors are some of the most promising types of sensors for monitoring various physiological analytes due to their implementation as non-invasive and portable devices. Advantages in reduced analysis time, cost-effectiveness, selective sensing, and simple techniques with low-powered circuits distinguish voltammetric sensors from other methods. In this work, we developed a Cu2O-based non-enzymatic portable glucose sensor on a graphene paste printed on cellulose cloth. The electron transfer of Cu2O in a NaOH alkaline medium and sweat equivalent solution at very low potential (+0.35 V) enable its implementation as a low-powered portable glucose sensor. The redox mechanism of the electrodes with the analyte solution was confirmed through cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy studies. The developed biocompatible, disposable, and reproducible sensors showed sensing performance in the range of 0.1 to 1 mM glucose, with a sensitivity of 1082.5 ± 4.7% µA mM−1 cm−2 on Cu2O coated glassy carbon electrode and 182.9 ± 8.83% µA mM−1 cm−2 on Cu2O coated graphene printed electrodes, making them a strong candidate for future portable, non-invasive glucose monitoring devices on biodegradable substrates. For portable applications we demonstrated the sensor on artificial sweat in 0.1 M NaOH solution, indicating the Cu2O nanocluster is selective to glucose from 0.0 to +0.6 V even in the presence of common interference such as urea and NaCl.

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Section: Cu 2 O Nanocluster Study On Gcesupporting

confidence: 91%

Cu2O-Based Electrochemical Biosensor for Non-Invasive and Portable Glucose Detection

2022

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“…Despite their promising results, none of them has been fully successful for use by the general population, since they do not provide a direct glycemia measurement [10]. CGM based upon electrochemical means are also being studied [11,12,13,14,15,16], but the continuous need of disposable stuff and the errors they present [17] (mainly because of the inflammation of the skin in the surroundings of the sensor placing) suggest that alternative solutions should be explored [18,19]. Some other methods have been investigated, such as trying to measure glycemia from the individual’s breath [20,21], saliva [22], tears [23,24], or gingival crevicular fluid [25], although conclusive results have not been found yet.…”

Section: Introductionmentioning

confidence: 99%

Glucose Concentration Measurement in Human Blood Plasma Solutions with Microwave Sensors

Juan

Bronchalo

Potelon

et al. 2019

Sensors

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Three microwave sensors are used to track the glucose level of different human blood plasma solutions. In this paper, the sensors are evaluated as glucose trackers in a context close to real human blood. Different plasma solutions sets were prepared from a human blood sample at several added glucose concentrations up to 10 wt%, adding also ascorbic acid and lactic acid at different concentrations. The experimental results for the different sensors/solutions combinations are presented in this work. The sensors show good performance and linearity as glucose level retrievers, although the sensitivities change as the rest of components vary. Different sensor behaviors depending upon the concentrations of glucose and other components are identified and characterized. The results obtained in terms of sensitivity are coherent with previous works, highlighting the contribution of glucose to the dielectric losses of the solution. The results are also consistent with the frequency evolution of the electromagnetic signature of glucose found in the literature, and are helpful for selecting frequency bands for sensing purposes and envisioning future approaches to the challenging measurement in real biological contexts. Discussion of the implications of the results and guidelines for further research and development of more accurate sensors is offered.

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“…The ultralow detection capability is believed to stem from the combination of Cu, Cu 3 (PO 4 ) 2 , and Cu 2 O, which is formed as a result of the CV treatment in PBS and reduction of CuO to Cu 2 O. All three materials have previously been used for glucose detection and have demonstrated exceptional performance [ 54 , 55 , 56 , 57 ].…”

Section: Resultsmentioning

confidence: 99%

Non-Enzymatic Detection of Glucose in Neutral Solution Using PBS-Treated Electrodeposited Copper-Nickel Electrodes

et al. 2021

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Transition metals have been explored extensively for non-enzymatic electrochemical detection of glucose. However, to enable glucose oxidation, the majority of reports require highly alkaline electrolytes which can be damaging to the sensors and hazardous to handle. In this work, we developed a non-enzymatic sensor for detection of glucose in near-neutral solution based on copper-nickel electrodes which are electrochemically modified in phosphate-buffered saline (PBS). Nickel and copper were deposited using chronopotentiometry, followed by a two-step annealing process in air (Step 1: at room temperature and Step 2: at 150 °C) and electrochemical stabilization in PBS. Morphology and chemical composition of the electrodes were characterized using scanning electron microscopy and energy-dispersive X-ray spectroscopy. Cyclic voltammetry was used to measure oxidation reaction of glucose in sodium sulfate (100 mM, pH 6.4). The PBS-Cu-Ni working electrodes enabled detection of glucose with a limit of detection (LOD) of 4.2 nM, a dynamic response from 5 nM to 20 mM, and sensitivity of 5.47 ± 0.45 μA cm−2/log10(mole.L−1) at an applied potential of 0.2 V. In addition to the ultralow LOD, the sensors are selective toward glucose in the presence of physiologically relevant concentrations of ascorbic acid and uric acid spiked in artificial saliva. The optimized PBS-Cu-Ni electrodes demonstrate better stability after seven days storage in ambient compared to the Cu-Ni electrodes without PBS treatment.

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In Situ Oxidation of Cu2O Crystal for Electrochemical Detection of Glucose

Cited by 46 publications

References 62 publications

Cu2O-Based Electrochemical Biosensor for Non-Invasive and Portable Glucose Detection

Cu2O-Based Electrochemical Biosensor for Non-Invasive and Portable Glucose Detection

Glucose Concentration Measurement in Human Blood Plasma Solutions with Microwave Sensors

Non-Enzymatic Detection of Glucose in Neutral Solution Using PBS-Treated Electrodeposited Copper-Nickel Electrodes

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