In-situ photopolymerized C4-functionalized organosilicon monoliths for reversed-phase protein separation in nano-liquid chromatography

Kip, Çiğdem; Liu, Siyao; Fu, Xinyue; Tuncel, Alï; Lämmerhofer, Michael

doi:10.1016/j.talanta.2019.01.116

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…In situ photopolymerization of polymer-rich systems drive the fabrication of nanocomposites and nanocomposite gels, anisotropic particles, solid-state solar cells, electrodes for solar cells and supercapacitors, ionic-liquid-rich gel electrolyte, flexible broadband mirrors, gas sensors, , core–shell and hybrid nanofibers, monoliths for protein separation, functional biomaterial microstructures, customized nanoparticles and hydrogels for various applications, − and many more. The process of 3D printing with polymer inks has been extensively employing such in situ polymerization ( in situ curing) of deposited and spreading polymer drops and traces. − Such in situ curing of the printed polymer traces significantly enhances the rate of 3D printing.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Microdroplet Curing: Unravelling the Physics of On-Spot Photopolymerization

Sivasankar

Sachar

Sinha

et al. 2020

ACS Appl. Polym. Mater.

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Droplet-based direct-write printing (one form of 3D printing) methods, like inkjet printing, aerosol jet printing (AJP), etc., have changed our ideas about bottom-up additive manufacturing. AJP is capable of 3D printing by depositing microdroplets that lead to certain benefits in 3D printing of microscale structures. Here, we study the in situ photopolymerization-based curing of a microdroplet. The droplet is simultaneously spreading and curing, which leads to the rise of two time scales, the spreading time scale (τs) and the photopolymerization time scale (τp). When τs ≪ τp, the spreading occurs very fast and is independent of polymerization. If the time scales are of the same order (τs ∼ τp), the spreading is significantly affected by the polymerization. For this case, a progressive increase in the viscosity of the drop during the spreading ensures a much slower spreading and also a much weaker extent of spreading (i.e., the spreading ceases at a much smaller spreading radius of the drop). This complex thermofluidics is eventually manifested as distinct differences in the time-dependent velocity, temperature, and curing (or equivalently, monomer concentration) profiles within the drop between the two cases.

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Section: Introductionmentioning

confidence: 99%

3D Printed Microdroplet Curing: Unravelling the Physics of On-Spot Photopolymerization

Sivasankar

Sachar

Sinha

et al. 2020

ACS Appl. Polym. Mater.

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“…Due to the incorporation of POSS, the monoliths show good mechanical and pH stability. In recent years, many kinds of POSS-based hybrid monolithic columns with different functional groups have been prepared via free radical polymerization, [86][87][88] ring-opening polymerization 89,90 and click polymerization. [91][92][93][94] These monoliths were fabricated as simple as polymeric monoliths, whereas their porous structure and morphology were remarkably discriminated by the co-polymerization methods.…”

Section: Monolithic Columnsmentioning

confidence: 99%

Chromatographic separation of peptides and proteins for characterization of proteomes

Liang

Zhang

2023

Chem. Commun.

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“…Fast photoinitiated one-pot thiol-ene click polymerization of POSS monomers with various organic reagents played a key role in many recent studies [88][89][90][91][92][93][94]. Bai et al reported a multistep approach for the preparation of POSS monolith with hydrophilic properties.…”

Section: Poss-ma 1-butyl-3-vinylimidazoliumbis[(trifluoromethyl)sulfo...mentioning

confidence: 99%

“…The hydrophobicity of the ODT column was comparable to silica-C18-based but had very poor column efficiency of 32 000 plates/m for benzene. In a subsequent study, C-4 functionalized POSS-based monoliths were prepared via UV-initiated free radical polymerization of POSS-MA with butyl methacrylate and via thiol-ene polymerization with butanethiol [91]. Both columns were applied toward the gradient separation of proteins in reversed-phase nanoLC.…”

Section: Poss-ma 1-butyl-3-vinylimidazoliumbis[(trifluoromethyl)sulfo...mentioning

confidence: 99%

Review of recent advances in development and applications of organic‐silica hybrid monoliths

Zajickova

2023

J of Separation Science

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Organic‐silica hybrid monoliths attracted attention as an alternative to extensively researched organic polymer‐based and silica‐based counterparts. The development and applications of these materials as extraction and separation media in capillary liquid chromatography and capillary electrochromatography were previously reviewed in several manuscripts. In this review, we will concentrate on work published since mid‐2016 focusing on advances in their development using sol‐gel chemistry of tetra‐ and trialkoxysilanes and subsequent surface modification with organic monomers, and “one‐pot” strategy incorporating sol‐gel chemistry of alkoxysilanes and free‐radical polymerization, ring‐opening polymerization, or thiol‐based click polymerization with organic monomers. Approaches adapted to the preparation of hybrid monoliths made with polyhedral oligomeric silsesquioxanes will be covered as well.

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In-situ photopolymerized C4-functionalized organosilicon monoliths for reversed-phase protein separation in nano-liquid chromatography

Cited by 10 publications

References 23 publications

3D Printed Microdroplet Curing: Unravelling the Physics of On-Spot Photopolymerization

3D Printed Microdroplet Curing: Unravelling the Physics of On-Spot Photopolymerization

Chromatographic separation of peptides and proteins for characterization of proteomes

Review of recent advances in development and applications of organic‐silica hybrid monoliths

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