In situ pollution induced cytochrome P450 activity of freshwater fish: barbel (Barbus barbus), chub (Leuciscus cephalus) and nase (Chondrostoma nasus)

Vindimian, Éric; Namour, Philippe; Migeon, Bernard; Garric, Jeanne

doi:10.1016/0166-445x(91)90076-l

Cited by 45 publications

(28 citation statements)

References 26 publications

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“…As previously reported by Masfaraud et al (1990) and Vindimian et al (1991), a sex-related difference was found in the hepatic EROD activity of chubs caught at the different stations. This difference was probably due to the influence of sex steroids, and particularly estradiol-17β, on hepatic mono-oxygenase activity (Vodicnik and Lech, 1983;O'Hare et al, 1995).…”

Section: Biochemical Measurementssupporting

confidence: 86%

“…Other levels of organization were investigated in chub (Leuciscus cephalus) as a sentinel species (Vindimian et al, 1991;Devaux et al, 1998;Flammarion et al, 2002). This species was selected because of its wide distribution across the studied area, its tolerance to water pollution and its large size ensuring the necessary supply of biological material for assays.…”

Section: Introductionmentioning

confidence: 99%

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Multiscale approach of fish responses to different types of environmental contaminations: A case study

Mayon

Bertrand

Leroy

et al. 2006

Science of The Total Environment

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In order to study the responses of wild fish to environmental contaminations, different sites (two references and three contaminated) were sampled across the Walloon hydrographical network (southern Belgium). The status of fish communities was characterized according to an index of biotic integrity (IBI). Furthermore, population structure, reproductive parameters and biochemical assays were performed on chub (Leuciscus cephalus) as sentinel species. The results showed impaired responses in fish sampled downstream paper mill effluents (BKME), in a polychlorinated biphenyls (PCB) contaminated site, and in a river receiving pesticides (i.e. atrazine and hexachlorocyclohexane). High level of hepatic 7-ethoxyresorufin-Odeethylase (EROD) activity were evidence of direct toxicant exposure, while population structures showed unbalanced size-frequency distributions. Moreover, in the pesticide contaminated site, a higher proportion of atretic oocytes was found in females and abnormally high plasma alkali-labile phosphorus (ALP) values were noticed in males, compared to reference sites, suggesting that chubs were exposed to estrogenic compounds. IBI scores from both sites were also lower than in reference sites. On the other hand, no particular response was found in hepatic glutathione-S-transferase (GST) activities, hepatic heat-shock protein HSP70 concentrations and plasma sex steroids (estradiol-17β, 11-ketotestosterone and testosterone) in chubs from any sites. By using a multiparametric approach, a better understanding of response mechanisms to pollution in fish may be achieved in order to improve the ecological status of river ecosystems.

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Section: Biochemical Measurementssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Multiscale approach of fish responses to different types of environmental contaminations: A case study

Mayon

Bertrand

Leroy

et al. 2006

Science of The Total Environment

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“…Since most lipophilic toxicants in aquatic systems preferentially bind to sediments (Ahlf et al 2002), benthic fish species such as the barbel run an increased risk of being exposed to elevated levels of contamination than pelagic fish. For instance, barbel has been shown to be more strongly contaminated by polychlorinated biphenyls (PCBs) than salmonids and other cyprinids from the same locations (Keck & Raffenot 1979, Vindimian et al 1991, Hugla et al 1995. Hugla et al (1995) correlated alterations in liver ultrastructure similar to our observations to high PCB concentrations in barbel from the River Meuse, and PCBs have also been shown to generate a multitude of hepatic alterations in other studies (Weibel & Paumgartner 1978, Hugla et al 1996, Hugla & Thomé 1999.…”

Section: Reasons For Fish Decline In the Danube Riversupporting

confidence: 79%

Assessment of fish health status in the Upper Danube River by investigation of ultrastructural alterations in the liver of barbel Barbus barbus

Grund¹,

Keiter²,

Böttcher³

et al. 2010

Dis. Aquat. Org.

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Despite intensive efforts and tightened guidelines for improvement of water quality over the last 2 decades, declines of fish populations have been reported for several rivers around the world. The present study forms part of a comprehensive weight-of-evidence approach, which aims to identify potential causes for the decline in fish catches observed in the Upper Danube River. The major focus of the present study is the investigation of the health status of wild barbel Barbus barbus L. collected from 3 locations along the Danube River, which experienced different levels of contamination. Whereas the comparison of the condition factor (CF) of field fish with that of control fish revealed no differences, ultrastructural investigations indicated severe disturbance of hepatic cell metabolism in field fish from the more contaminated sites Rottenacker and Ehingen, compared to both control fish and field fish from the less contaminated site Riedlingen. The ultrastructural analysis provided information about reactions of e.g. the rough endoplasmic reticulum, peroxisomes, and mitochondria, indicating an impaired health status of barbel at the sampling sites Rottenacker and Ehingen. Even though a straightforward cause-effect relationship between sediment contamination and ultrastructural alterations could not be established, based on a meta-analysis and toxicity assays it may be suggested that sediment-bound xenobiotics at least partly account for the hepatocellular changes. A relationship between impaired fish health status and the decline of fish catches along the Upper Danube River cannot be excluded.

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“…In 1995 six areas were investigated: three unpolluted areas (Ain, Arde`che, Droˆme), one moderately polluted area (Saoˆne), and two highly polluted areas (Rhoˆne 1 and Rhoˆne 2). EROD measurements done by the same laboratory on freshwater fish from the Rhoˆne watershed in previous selective studies (Vindimian et al, 1991(Vindimian et al, , 1993Richert, 1994), were also considered and relationships between EROD and bioaccumulated pollutants were validated with results from three stations on the Rhoˆne and the Saoˆne (in spring 1995) -Tre´voux, Jons, and Vernaison-that were not included in the statistical analysis.…”

Section: Sampling Sitesmentioning

confidence: 99%

Statistical Analysis of Cyprinid Ethoxyresorufin-O-deethylase Data in a Large French Watershed

Flammarion

Migeon

Garric

1998

Ecotoxicology and Environmental Safety

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In situ pollution induced cytochrome P450 activity of freshwater fish: barbel (Barbus barbus), chub (Leuciscus cephalus) and nase (Chondrostoma nasus)

Cited by 45 publications

References 26 publications

Multiscale approach of fish responses to different types of environmental contaminations: A case study

Multiscale approach of fish responses to different types of environmental contaminations: A case study

Assessment of fish health status in the Upper Danube River by investigation of ultrastructural alterations in the liver of barbel Barbus barbus

Statistical Analysis of Cyprinid Ethoxyresorufin-O-deethylase Data in a Large French Watershed

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