In‐situ preparation of porous monolithic polymer inside hollow fiber as a micro‐solid phase extraction device for glucocorticoids in cosmetics

Abstract

Glucocorticoids have a certain whitening effect on the skin. However, frequent and long‐term use of cosmetics including glucocorticoids is harmful to health. Herein, we proposed a novel micro‐solid phase extraction method for the detection of prednisolone acetate, prednisone, and prednisolone in cosmetics coupled with high‐performance liquid chromatography. In this method, porous monolithic polymer micro‐extraction bars were prepared by “one‐step, one‐pot” in situ photopolymerization combined with sacrificial support in hollow fiber under water atmosphere. The crucial factors such as pH of sample solution, extraction, and elution times that influence micro‐extraction were optimized and found to be 9.0, 2 h, and 32 min, respectively. Under the optimum experimental conditions, the linear range of the calibration curves were from 5.0 to 2000 µg/L with correlation coefficients (R2) between 0.9922 and 0.9996. The limit of detection and limit of quantification were 1.5 µg/L and 5.0 µg/L, respectively, and the recoveries were found to be in range of 69.0–113.3%. The analysis of precision for intraday and interday were less than 10.40 and 10.59%. The device has been successfully achieved photopolymerization under water atmosphere. The results indicated that this method is simple, accurate, and satisfactory for the pretreatment and determination of glucocorticoids in complex cosmetics samples.

A membrane‐protected micro‐solid‐phase extraction method based on molecular imprinting and its application to the determination of local anesthetics in cosmetics

“…HF–μSPE fibers were prepared as we previously reported [27]. In short, Accurel Q 3/2 polypropylene hollow fibers (HFs, 600‐μm ID, 200‐μm wall thickness, and 0.2‐μm pore size) were cut into 3‐cm long pieces, ultrasonicated with acetone for 20 min, dried, and carefully weighed (m 1 ).…”

“…A device was constructed by placing a few adsorbents into a two-dimensional hollow-fiber membrane to prevent direct contact between the adsorbents and complex matrices, which largely eliminated matrix interference, and reduced adsorbent loss [25,26]. The HF-μSPE device [27,28] is simple and versatile, and the packing material can either be produced in-house or purchased commercially. The packing material affects the efficiency of HF-μSPE significantly [29].…”

Advances on Hormones in Cosmetics: Illegal Addition Status, Sample Preparation, and Detection Technology

“…Combined with HPLC, some modified PMME columns have been used as the extraction media for the determination of sex hormones, including estrogen, testosterone, methyltestosterone, and progesterone in cosmetics with the low LODs (not over 4.6 μg L –1 ) [ 67 , 68 ]. Based on the above features, Wei et al [ 69 ] prepared a porous monolithic polymer inside fiber by in situ photopolymerization combined with sacrificial support in hollow fiber ( Figure 4 c). Coupled with HPLC, this fabricated micro-SPE (µ-SPE) device could be used for prednisone acetate, prednisone and prednisolone determination in lotions with the LOD of 1.5 μg L –1 and recoveries of 69.0–113.3%.…”

A sound-absorbing and heat-insulating collagen fiber composite material

“…Polymer hollow microspheres (PHM) are special microspheric materials with internal cavity structures. They have the characteristics of low density, large specific surface area, light weight, and excellent light scattering properties, and are often used as a covering pigment , [27] an additive for UV protection, 28 a drug carrier 29 and an additive for sound-absorbing and insulating materials. 30 Hollow microspheres filled with animal skin materials are mostly related to medical applications.…”