In Situ Reductive Synthesis of Structural Supported Gold Nanorods in Porous Silicon Particles for Multifunctional Nanovectors

Zhu, Guixian; Liu, Jen Tsai; Wang, Yuzhen; Zhang, Dechen; Guo, Yi; Tasciotti, Ennio; Hu, Zhongbo; Liu, Xuewu

doi:10.1021/acsami.6b03008

Cited by 21 publications

(20 citation statements)

References 63 publications

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“…PSi microdisks have been proved as excellent carriers in drug delivery . Mesoporous PSi microdisks, fabricated through photolithography and electrochemical etching, have great biocompatibility and biodegradability . The mesoporous structures endow PSi with high loading efficiency of active agents.…”

Section: Resultsmentioning

confidence: 99%

“…[43] Mesoporous PSi microdisks, fabricated through photolithography and electrochemical etching, have great biocompatibility and biodegradability. [44] The mesoporous structures endow PSi with high loading efficiency of active agents. However, smaller drug molecules cannot be loaded in mesoporous porous efficiently simply via physical absorption.…”

Section: Full Papermentioning

confidence: 99%

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Hollow Mesoporous Metal‐Organic Framework Microdisks via a Solid Template‐Based Approach and Post‐Synthetic Wet‐Chemical Etching for Protein Loading

Zhu

Cheng

et al. 2020

ChemNanoMat

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Metal‐organic frameworks (MOFs), with high crystalline and ordered pore structures, hold great potential for various applications. However, the small microporous structures of MOFs restrict their applications. MOFs with larger porous structure and dimensions can expand their functionality to integrate with other large active agents. By applying porous silicon microdisks (PSi) as hard templates, zeolitic imidazolate frameworks (ZIFs) were assembled on PSi to form PSi@ZIF‐8 core‐shell microdisks. A new porous structure of ZIF‐8 microcages was obtained via a post‐synthetic approach. The influence of PSi and reaction precursor for ZIF‐8 were explored, and the formation mechanism of mesoporous ZIF‐8 (PZIF‐8) hollow microcages was also proposed. By applying bovine serum albumin (BSA) as a loading agent, the protein release behavior of PSi@PZIF‐8 was investigated. It is noted that prepared PZIF‐8 microcages could serve as new vectors for loading active agents.

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Section: Resultsmentioning

confidence: 99%

Section: Full Papermentioning

confidence: 99%

Hollow Mesoporous Metal‐Organic Framework Microdisks via a Solid Template‐Based Approach and Post‐Synthetic Wet‐Chemical Etching for Protein Loading

Zhu

Cheng

et al. 2020

ChemNanoMat

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“…Plasmonic metallic nanostructures can be formed on porous silicon by different ways such as thermal decomposition [ 17 , 35 , 75 ], immersion deposition [ 74 , 77 , 83 , 89 , 92 , 93 ], deposition from colloids [ 64 , 68 , 94 ], evaporation [ 34 , 37 ], sputtering [ 36 , 37 , 53 ], physical vapor deposition (PVD) [ 95 , 96 , 97 ], pulsed laser deposition (PLD) [ 68 , 98 ], chemical deposition [ 99 ], and electrochemical plating [ 16 , 52 , 69 ]. However, here, we will only describe immersion deposition and thermal decomposition in detail.…”

Section: Approaches For Coating Porous Silicon With Metals For Sermentioning

confidence: 99%

“…The later porous silicon layer thinning was observed during its storage in mineral water that had a pH = 7.2 and 8.1, at 18 °C [ 122 ]. Recently, the degradation of the SERS-active mesoporous silicon disks permeated with gold rods was observed at a pH of 7.4 [ 99 ]. The silicon skeleton was completely dissolved during the 8 h leading to the aggregation of the gold nanostructures and their loss of SERS-activity.…”

Section: Limitationsmentioning

confidence: 99%

Progress in the Development of SERS-Active Substrates Based on Metal-Coated Porous Silicon

et al. 2018

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The present work gives an overview of the developments in surface-enhanced Raman scattering (SERS) with metal-coated porous silicon used as an active substrate. We focused this review on the research referenced to SERS-active materials based on porous silicon, beginning from the patent application in 2002 and enclosing the studies of this year. Porous silicon and metal deposition technologies are discussed. Since the earliest studies, a number of fundamentally different plasmonic nanostructures including metallic dendrites, quasi-ordered arrays of metallic nanoparticles (NPs), and metallic nanovoids have been grown on porous silicon, defined by the morphology of this host material. SERS-active substrates based on porous silicon have been found to combine a high and well-reproducible signal level, storage stability, cost-effective technology and handy use. They make it possible to identify and study many compounds including biomolecules with a detection limit varying from milli- to femtomolar concentrations. The progress reviewed here demonstrates the great prospects for the extensive use of the metal-coated porous silicon for bioanalysis by SERS-spectroscopy.

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“…Previous pSi dissolution studies have typically involved direct visualization/monitoring of a planar pSi wafer surface using techniques such as atomic force microscope (AFM), scanning electron microscope (SEM) [1,31,32], photoluminescent and infrared spectroscopies [33,34]. However, these approaches provide only qualitative or semi-quantitative topographic and/or pSi speciation information to assess pSi degradation.…”

Section: Introductionmentioning

confidence: 99%

Controlling and Predicting the Dissolution Kinetics of Thermally Oxidised Mesoporous Silicon Particles: Towards Improved Drug Delivery

2019

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Porous silicon (pSi) continues to receive considerable interest for use in applications ranging from sensors, biological scaffolds, therapeutic delivery systems to theranostics. Critical to all of these applications is pSi degradation and stabilization in biological media. Here we report on progress towards the development of a mechanistic understanding for the dissolution behavior of native (unoxidized) and thermally oxidized (200–600 °C) pSi microparticles. Fourier transform infrared (FTIR) spectroscopy was used to characterize the pSi surface chemistry after thermal oxidation. PSi dissolution was assessed using a USP method II apparatus by monitoring the production of orthosilicic acid, and the influence of gastro-intestinal (GI) fluids were examined. Fitting pSi dissolution kinetics with a sum of the exponential model demonstrated that the dissolution process strongly correlates with the three surface hydride species and their relative reactivity, and was supported by the observed FTIR spectral changes of pSi during dissolution. Finally, the presence of GI proteins was shown to hamper pSi dissolution by adsorption to the pSi surface acting as a barrier preventing water attack. These findings are significant in the optimal design of pSi particles for oral delivery and other controlled drug delivery applications.

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In Situ Reductive Synthesis of Structural Supported Gold Nanorods in Porous Silicon Particles for Multifunctional Nanovectors

Cited by 21 publications

References 63 publications

Hollow Mesoporous Metal‐Organic Framework Microdisks via a Solid Template‐Based Approach and Post‐Synthetic Wet‐Chemical Etching for Protein Loading

Hollow Mesoporous Metal‐Organic Framework Microdisks via a Solid Template‐Based Approach and Post‐Synthetic Wet‐Chemical Etching for Protein Loading

Progress in the Development of SERS-Active Substrates Based on Metal-Coated Porous Silicon

Controlling and Predicting the Dissolution Kinetics of Thermally Oxidised Mesoporous Silicon Particles: Towards Improved Drug Delivery

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