In-situ SEM micropillar compression of porous and dense zirconia materials

Juri, Afifah Z.; Basak, A.K.; Yin, Ling

doi:10.1016/j.jmbbm.2022.105268

Cited by 6 publications

(2 citation statements)

References 39 publications

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“…The HDBM, HDBM-0.6% GT, and PDBM frameworks were dried to critical points and examined by SEM. 28 The pore diameters of each framework were calculated using the ImageJ microscopy analysis software. After in vitro seeding of the cells into the frameworks and culturing for 1, 4, and 7 days, the cell-HDBM, cell-HDBM-0.6%GT, and cell-PDBM frameworks were washed with PBS and fixed in 0.05% glutaraldehyde overnight at 4 °C.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Regeneration of Mechanically Enhanced Tissue-Engineered Cartilage Based on the Decalcified Bone Matrix Framework

Song

Guo

et al. 2023

ACS Biomater. Sci. Eng.

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Human decalcified bone matrix (HDBM) is a framework with a porous structure and good biocompatibility. Nevertheless, its oversized pores lead to massive cell loss when seeding chondrocytes directly over it. Gelatin (GT) is a type of protein obtained by partial hydrolysis of collagen. The GT scaffold can be prepared from the GT solution through freeze-drying. More importantly, the pore size of the GT scaffold can be controlled by optimizing the concentration of the GT solution. Similarly, when different concentrations of gelatin are combined with HDBM and then freeze-dried, the pore size of the HDBM can be modified to different degrees. In this study, the HDBM framework was modified with 0.3, 0.6, and 0.9%GT, resulting in an improved pore size and adhesion rate. Results showed that the HDBM framework with 0.6%GT (HDBM-0.6%GT) had an average pore size of 200 μm, which was more suitable for chondrocyte seeding. Additionally, our study validated that porcine decalcified bone matrix (PDBM) had a proper pore structure. Chondrocytes were in vitro seeded on the three frameworks for 4 weeks and then implanted in nude mice and autologous goats, respectively. The in vivo cartilage regeneration results showed that HDBM-0.6%GT and PDBM frameworks compensated for the oversized pores of the HDBM framework. Moreover, they showed successfully regenerated more mature cartilage tissue with a certain shape in animals.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

“…The HDBM, HDBM-0.6%GT, and PDBM frameworks were dried to critical points and examined by SEM . The pore diameters of each framework were calculated using the ImageJ microscopy analysis software.…”

Section: Methodsmentioning

confidence: 99%

Regeneration of Mechanically Enhanced Tissue-Engineered Cartilage Based on the Decalcified Bone Matrix Framework

Song

Guo

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

Effect of sintering time on the microstructure and stability of Al2O3–ZrO2 composite powders under microwave-assisted sintering

Huang

Zhang

et al. 2023

Ceramics International

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On the microscale deformation of the oxide layer formed on a Zr-2.5 Nb alloy: A micropillar compression study

Shaik,

Roy,

Topping

et al. 2024

Corrosion Science

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In-situ SEM micropillar compression of porous and dense zirconia materials

Cited by 6 publications

References 39 publications

Regeneration of Mechanically Enhanced Tissue-Engineered Cartilage Based on the Decalcified Bone Matrix Framework

Regeneration of Mechanically Enhanced Tissue-Engineered Cartilage Based on the Decalcified Bone Matrix Framework

Effect of sintering time on the microstructure and stability of Al2O3–ZrO2 composite powders under microwave-assisted sintering

On the microscale deformation of the oxide layer formed on a Zr-2.5 Nb alloy: A micropillar compression study

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In-situ SEM micropillar compression of porous and dense zirconia materials

Cited by 6 publications

References 39 publications

Regeneration of Mechanically Enhanced Tissue-Engineered Cartilage Based on the Decalcified Bone Matrix Framework

Regeneration of Mechanically Enhanced Tissue-Engineered Cartilage Based on the Decalcified Bone Matrix Framework

Effect of sintering time on the microstructure and stability of Al2O3–ZrO2 composite powders under microwave-assisted sintering

On the microscale deformation of the oxide layer formed on a Zr-2.5 Nb alloy: A micropillar compression study

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On the microscale deformation of the oxide layer formed on a Zr-2.5 Nb alloy: A micropillar compression study