In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

Chen, Qian; Wang, Chao; Zhang, Xudong; Chen, Guojun; Hu, Quanyin; Li, Hongjun; Wang, Jinqiang; Wen, Di; Zhang, Yuqi; Lü, Yifei; Yang, Guang; Jiang, Chen; Wang, Jun; Dotti, Gianpietro; Gu, Zhen

doi:10.1038/s41565-018-0319-4

Cited by 830 publications

(566 citation statements)

References 49 publications

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“…Several other inorganic nanoparticle types have been used for immunotherapy. An anti‐CD47‐functionalized CaCO 3 nanoparticle was incorporated into a sprayable gel by Gu and co‐workers for postsurgical cancer treatment . Anti‐CD47 was designed to release from the nanoparticles once in the acidic tumor microenvironment, blocking the anti‐phagocytic signal to macrophages.…”

Section: Nanoscale Materials For Immunotherapymentioning

confidence: 99%

“…The hydrogel contained ROS‐sensitive moieties that enabled the slow release of checkpoint inhibitors to ROS‐producing melanoma lesions. Most recently, another postsurgical peptide hydrogel was developed by Gu and co‐workers ( Figure ) . Here, a fibrin‐based hydrogel that included CaCO 3 nanoparticles encapsulating anti‐CD47 was formulated into a spray.…”

Section: Macroscale Materials For Immunotherapymentioning

confidence: 99%

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Materials for Immunotherapy

et al. 2019

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Breakthroughs in materials engineering have accelerated the progress of immunotherapy in preclinical studies. The interplay of chemistry and materials has resulted in improved loading, targeting, and release of immunomodulatory agents. An overview of the materials that are used to enable or improve the success of immunotherapies in preclinical studies is presented, from immunosuppressive to proinflammatory strategies, with particular emphasis on technologies poised for clinical translation. The materials are organized based on their characteristic length scale, whereby the enabling feature of each technology is organized by the structure of that material. For example, the mechanisms by which i) nanoscale materials can improve targeting and infiltration of immunomodulatory payloads into tissues and cells, ii) microscale materials can facilitate cell‐mediated transport and serve as artificial antigen‐presenting cells, and iii) macroscale materials can form the basis of artificial microenvironments to promote cell infiltration and reprogramming are discussed. As a step toward establishing a set of design rules for future immunotherapies, materials that intrinsically activate or suppress the immune system are reviewed. Finally, a brief outlook on the trajectory of these systems and how they may be improved to address unsolved challenges in cancer, infectious diseases, and autoimmunity is presented.

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Section: Nanoscale Materials For Immunotherapymentioning

confidence: 99%

Section: Macroscale Materials For Immunotherapymentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

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“…[10][11][12][13][14][15][16] Thus, complementary approaches to enhance the immunogenicity and reverse the ITM remain a formidable challenge for improving immunotherapy of TNBC. [21][22][23][24][25][26] However, combination immu notherapy suffers from the distinct chemophysical properties and incon sistent pharmacokinetic profiles of the different immune modulators. [21][22][23][24][25][26] However, combination immu notherapy suffers from the distinct chemophysical properties and incon sistent pharmacokinetic profiles of the different immune modulators.…”

mentioning

confidence: 99%

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Feng

Niu

Hou

et al. 2019

Adv Funct Materials

161

115

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Combination cancer immunotherapy has shown promising potential for simultaneously eliciting antitumor immunity and modulating the immunosuppressive tumor microenvironment (ITM). However, combination immunotherapy with multiple regimens suffers from the varied chemophysical properties and inconsistent pharmacokinetic profiles of the different therapeutics. To achieve tumor-specific codelivery of the immune modulators, an indocyanine green (ICG)-templated self-assembly strategy for preparing dual drug-loaded two-in-one nanomedicine is reported. ICG-templated self-assembly of paclitaxel (PTX) nanoparticles (ISPN), and the application of ISPN for combination immunotherapy of the triple negative breast cancer (TNBC) are demonstrated. The ISPN show satisfied colloidal stability and high efficacy for tumor-specific codelivery of ICG and PTX through the enhanced tumor permeability and retention effect. Upon laser irradiation, the ICG component of ISPN highly efficiently induces immunogenic cell death of the tumor cells via activating antitumor immune response through photodynamic therapy. Meanwhile, PTX delivered by ISPN suppresses the regulatory T lymphocytes (T regs ) to combat ITM. The combination treatment of TNBCwith ISPN and αPD-L1-medaited immune checkpoint blockade therapy displays a synergistic effect on tumor regression, metastasis inhibition, and recurrence prevention. Overall, the ICG-templated nanomedicine may represent a robust nanoplatform for combination immunotherapy.

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“…[262,294,295] Black phosphorus quantum dot (BPQD) is a biodegradable NM with high photothermal conversion efficiency, which can be used to facilitate the release of granulocyte-macrophage colony-stimulating factor (GM-CSF) and lipopolysaccharide (LPS) to recruit and activate APCs. [260] The fibrin gel was formed in situ by simultaneously spraying and mixing equal volumes of two solutions of fibrinogen with anti-CD47 antibody-loaded CaCO 3 NPs (aCD47@CaCO 3 ) and thrombin based on the interaction of fibrinogen and thrombin (Figure 11a,b). [262] In combination with PD-1 antibody blockade, BPQD-CCNVs were applied for effective postoperative immunotherapy to reduce cancer recurrence and metastasis.…”

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

“…Design and characteristics of aCD47@CaCO3 NPs for post-surgical immunotherapy. Reproduced with permission [260]. b) i) FACS analysis gating on CD3 + cells and ii) absolute quantification of CD8 + and iii) CD4 + T cells in the tumor.…”

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confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

Cited by 830 publications

References 49 publications

Materials for Immunotherapy

Materials for Immunotherapy

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

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