In situ synchrotron radiation µCT indentation of cortical bone: Anisotropic crack propagation, local deformation, and fracture

Fernández, Marta Peña; Schwiedrzik, Jakob; Bürki, Alexander; Peyrin, Françoise; Michler, Johann; Zysset, Philippe; Wolfram, Uwe

doi:10.1016/j.actbio.2023.04.038

Cited by 5 publications

(1 citation statement)

References 103 publications

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“…This approach enables precise analysis of the complex 3D pattern of damage or fracture through the use of Digital Volume Correlation. This technique has been successfully applied to trabecular bone 13 , cortical bone 14 and polymer scaffolds reinforced with ceramic particles 15 , 16 . Since ceramic scaffolds are brittle, it is challenging to examine the scaffolds at intermediate configurations before a substantial fracture had propagated, especially in highly porous scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Micro-CT imaging and finite element models reveal how sintering temperature affects the microstructure and strength of bioactive glass-derived scaffolds

De Cet,

D’Andrea,

Gastaldi

et al. 2024

Sci Rep

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This study focuses on the finite element simulation and micromechanical characterization of bioactive glass-ceramic scaffolds using Computed micro Tomography ($$\upmu$$ μ CT) imaging. The main purpose of this work is to quantify the effect of sintering temperature on the morphometry and mechanical performance of the scaffolds. In particular, the scaffolds were produced using a novel bioactive glass material (47.5B) through foam replication, applying six different sintering temperatures. Through $$\upmu$$ μ CT imaging, detailed three-dimensional images of the scaffold’s internal structure are obtained, enabling the extraction of important geometric features and how these features change with sintering temperature. A finite element model is then developed based on the $$\upmu$$ μ CT images to simulate the fracture process under uniaxial compression loading. The model incorporates scaffold heterogeneity and material properties—also depending on sintering temperature—to capture the mechanical response, including crack initiation, propagation, and failure. Scaffolds sintered at temperatures equal to or higher than 700 $$^{\circ }$$ ∘ C exhibit two-scale porosity, with micro and macro pores. Finite element analyses revealed that the dual porosity significantly affects fracture mechanisms, as micro-pores attract cracks and weaken strength. Interestingly, scaffolds sintered at high temperatures, the overall strength of which is higher due to greater intrinsic strength, showed lower normalized strength compared to low-temperature scaffolds. By using a combined strategy of finite element simulation and $$\upmu$$ μ CT-based characterization, bioactive glass-ceramic scaffolds can be optimized for bone tissue engineering applications by learning more about their micromechanical characteristics and fracture response.

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Section: Introductionmentioning

confidence: 99%

Micro-CT imaging and finite element models reveal how sintering temperature affects the microstructure and strength of bioactive glass-derived scaffolds

De Cet,

D’Andrea,

Gastaldi

et al. 2024

Sci Rep

View full text Add to dashboard Cite

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Characterization of damage mechanisms in cortical bone: Quantification of fracture resistance, critical strains, and crack tortuosity

Gustafsson,

Galteri,

Barakat

et al. 2024

Journal of the Mechanical Behavior of Biomedical Materials

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Relationship between the microstructural energy release rate of cortical bone and age under compression condition

Fan,

Wang,

Jia

2024

Sci Rep

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Most studies evaluated the energy release rate of cortical bone macrostructure under Mode I, Mode II, and mixed Mode I-II loading conditions. However, testing the macrostructural energy release rate requires an initial crack and recording the applied load and the corresponding crack length in real-time, which may introduce measurement errors and differences with the actual fracture scenarios. To further understand how the energy release rate contributed to the cortical bone fracture characteristics, this study predicted the microstructural energy release rate of cortical bone and then investigated its age-related varitions. The microstructural energy release rate of femoral cortical bone in rats from different ages was back-calculated by fitting the experimental and simulated load–displacement curves under compression load. The trends in the microstructural energy release rate were revealed, and the underlying reasons for the age-related changes were investigated by integrating the discussion on the cortical bone mechanical parameters at various levels obtained from the previous experiment. The predicted microstructural energy release rate of femoral cortical bone in the rats from 1, 3, 5, 7, 9, 11, and 15 months of age were in the range of 0.08–0.12, 0.12–0.14, 0.15–0.19, 0.25–0.28, 0.23–0.25, 0.19–0.22, and 0.13–0.16 N/mm, respectively. The statistical analyses showed the significant differences in the microstructural energy release rate at different ages. The results indicated an increasing trend followed by a decrease from 1 to 15 months of age, and the correlations between microstructural energy release rate and age were significant. The age-related variations in the microstructural energy release rate may be linked to the changes in the microarchitecture, and the fracture load is influenced by the micro-level mechanical parameters. Notably, the age-related trends in microarchitecture and energy release rate were similar. These findings were valuable for understanding the mechanism underlying the weakening mechanical properties of cortical bone microstructure with age from an energy perspective.

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In situ synchrotron radiation µCT indentation of cortical bone: Anisotropic crack propagation, local deformation, and fracture

Cited by 5 publications

References 103 publications

Micro-CT imaging and finite element models reveal how sintering temperature affects the microstructure and strength of bioactive glass-derived scaffolds

Micro-CT imaging and finite element models reveal how sintering temperature affects the microstructure and strength of bioactive glass-derived scaffolds

Characterization of damage mechanisms in cortical bone: Quantification of fracture resistance, critical strains, and crack tortuosity

Relationship between the microstructural energy release rate of cortical bone and age under compression condition

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