In-situ synchrotron X-ray imaging of ultrasound (US)-generated bubbles: Influence of US frequency on microbubble cavitation for membrane fouling remediation

Ehsani, Masoume; Zhu, Ning; Doan, Huu; Lohi, Ali; Abdelrasoul, Amira

doi:10.1016/j.ultsonch.2021.105697

Cited by 20 publications

(9 citation statements)

References 31 publications

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“…In 1999, Burdin et al reported that active bubbles have a typical radius of 8 μm by 20 kHz sonication as determined by laser light diffraction [39] . Also, it was reported that the average bubble radius (135 μm) at 20 kHz was about 6.8 times of that (20 μm) at 40 kHz, while the average number of bubbles at 40 kHz was about 4.6 times of that at 20 kHz [40] . In 2002, Yasui calculated the range of the ambient bubble radius with increasing ultrasonic frequency, i.e., 0.1–100 μm, 0.1–10 μm, and 0.1–3 μm at 20, 140 and 1000 kHz [38] .…”

Section: Resultsmentioning

confidence: 97%

Medium-high frequency sonication dominates spherical-SiO2 nanoparticle size

Liu

Manzoli

et al. 2022

Ultrasonics Sonochemistry

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Section: Resultsmentioning

confidence: 97%

Medium-high frequency sonication dominates spherical-SiO2 nanoparticle size

Liu

Manzoli

et al. 2022

Ultrasonics Sonochemistry

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“…This may be attributed to the cavitation effect of ultrasound. Generally, there will be lots of tiny entrained air bubble nuclei (radius <0.1 μm) in the liquid. − Under the effect of ultrasound, they could continue to grow by bubble coalescence and rectified diffusion until they collapse adiabatically. ,− The collapse of bubbles would cause shock waves, microjets, and microturbulences, which will increase the chance of collisions between lysozyme molecules, thus producing more clusters necessary for nucleation. ,,, At the same time, the enhanced micromixing can ensure a more uniform degree of supersaturation, which will result in uniform particle size distribution. Moreover, the shock waves caused by cavitation can reduce the contact between crystals, thereby reducing the probability of aggregation and encapsulation of mother liquor. , Therefore, ultrasound can effectively enhance nucleation and prevent aggregation, thereby promoting the efficient production of proteins with uniform size and regular shape.…”

Section: Resultsmentioning

confidence: 99%

Enhancement of Continuous Crystallization of Lysozyme through Ultrasound

Mao

Zhao

et al. 2021

Org. Process Res. Dev.

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Protein drugs have attracted extensive attention from the academic community. However, crystallization of proteins is difficult and the yield of current main technologies is too low, which limits their large-scale industrial production. In this work, enhancement of continuous crystallization of lysozyme under an ultrasonic field was explored. A plug-flow tubular crystallizer, which was separated into a nucleation zone and a growth zone, was applied. The effect of ultrasound on steady-state time, crystal habit, particle size, particle size distribution, and the process yield was evaluated based on univariate analysis experiments. It was found that ultrasound can shorten the time for continuous crystallization to reach a steady state, reduce the degree of aggregation, and promote nucleation. Furthermore, the separation of the growth zone from the nucleation zone in the ultrasonic-assisted continuous crystallization can further increase the size of the lysozyme crystals, which would help in increasing the yield.

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“…Thus, spherical particles were used for conjugation with HSA, rods (sphericity ratio 0.85) were used for conjugation with FB, and cylinders (sphericity ratio 0.91) were used for conjugation with TRF. Detailed information about membrane imaging and radiograph representation with membrane division into layers and regions is described in our recent papers [ 38 , 39 , 40 , 41 , 42 ]. Membrane thickness was modeled with 10 regions of interest (ROIs), as shown in Figure 2 c. Region 1 represents the very top membrane surface.…”

Section: Methodsmentioning

confidence: 99%

Investigation on Human Serum Protein Depositions Inside Polyvinylidene Fluoride-Based Dialysis Membrane Layers Using Synchrotron Radiation Micro-Computed Tomography (SR-μCT)

2023

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Hemodialysis (HD) membrane fouling with human serum proteins is a highly undesirable process that results in blood activations with further severe consequences for HD patients. Polyvinylidene fluoride (PVDF) membranes possess a great extent of protein adsorption due to hydrophobic interaction between the membrane surface and non-polar regions of proteins. In this study, a PVDF membrane was modified with a zwitterionic (ZW) polymeric structure based on a poly (maleic anhydride-alt-1-decene), 3-(dimethylamino)-1-propylamine derivative and 1,3-propanesultone. Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and zeta potential analyses were used to determine the membrane’s characteristics. Membrane fouling with human serum proteins (human serum albumin (HSA), fibrinogen (FB), and transferrin (TRF)) was investigated with synchrotron radiation micro-computed tomography (SR-μCT), which allowed us to trace the protein location layer by layer inside the membrane. Both membranes (PVDF and modified PVDF) were detected to possess the preferred FB adsorption due to the Vroman effect, resulting in an increase in FB content in the adsorbed protein compared to FB content in the protein mixture solution. Moreover, FB was shown to only replace HSA, and no significant role of TRF in the Vroman effect was detected; i.e., TRF content was nearly the same both in the adsorbed protein layer and in the protein mixture solution. Surface modification of the PVDF membrane resulted in increased FB adsorption from both the protein mixture and the FB single solution, which is supposed to be due to the presence of an uncompensated negative charge that is located at the COOH group in the ZW polymer.

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In-situ synchrotron X-ray imaging of ultrasound (US)-generated bubbles: Influence of US frequency on microbubble cavitation for membrane fouling remediation

Abstract: Graphical abstract

Cited by 20 publications

References 31 publications

Medium-high frequency sonication dominates spherical-SiO2 nanoparticle size

Medium-high frequency sonication dominates spherical-SiO2 nanoparticle size

Enhancement of Continuous Crystallization of Lysozyme through Ultrasound

Investigation on Human Serum Protein Depositions Inside Polyvinylidene Fluoride-Based Dialysis Membrane Layers Using Synchrotron Radiation Micro-Computed Tomography (SR-μCT)

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