In situ synthesis of Au nanoparticles confined in 2D sheet-like metal organic frameworks to construct competitive PEC biosensor for sensitive analysis of autism spectrum disorder miRNA

Ultrasensitive amplification-free detection of circulating miRNA via droplet-based processing of SERS tag–miRNA–magnetic nanoparticle sandwich nanocomplexes on a paper-based electrowetting-on-dielectric platform

“…18,19 Thus, an alternative enzyme-free strategy and rapid simultaneous multiplexed detection technique for miRNAs is still urgently needed. Up to now, various amplification-free miRNA biosensors have been reported, including those based on electrochemical, 20 photoelectrochemical, 21 electrochemiluminescence, 22 field-effect transistor, 23 fluorescence, 24 surface plasmon resonance, 25 localized surface plasmon resonance, 26 waveguide interferometric, 27 and surface-enhanced Raman scattering. [28][29][30][31] The analytical performance of these biosensors is shown in Table S1.…”