In situ synthesis of homochiral metal–organic framework in capillary column for capillary electrochromatography enantioseparation

Pan, Congjie; Wang, Weifeng; Zhang, Huige; Xu, Laifang; Chen, Xingguo

doi:10.1016/j.chroma.2015.02.034

Cited by 75 publications

(34 citation statements)

References 43 publications

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“…However, aldehyde groups are rare in MOFs, so only a few MOFs can be used for this method. Thus, Chen and co‐workers developed an in situ self‐assembly method at room temperature. Chiral MOFs were synthesized in situ on the inner capillary walls.…”

Section: Application Of Mofs As Chromatographic Stationary Phasesmentioning

confidence: 99%

Recent advances in metal‐organic frameworks and covalent organic frameworks for sample preparation and chromatographic analysis

Wang

2017

Electrophoresis

111

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In the field of analytical chemistry, sample preparation and chromatographic separation are two core procedures. The means by which to improve the sensitivity, selectivity and detection limit of a method have become a topic of great interest. Recently, porous organic frameworks, such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), have been widely used in this research area because of their special features, and different methods have been developed. This review summarizes the applications of MOFs and COFs in sample preparation and chromatographic stationary phases. The MOF- or COF-based solid-phase extraction (SPE), solid-phase microextraction (SPME), gas chromatography (GC), high-performance liquid chromatography (HPLC) and capillary electrochromatography (CEC) methods are described. The excellent properties of MOFs and COFs have resulted in intense interest in exploring their performance and mechanisms for sample preparation and chromatographic separation.

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Section: Application Of Mofs As Chromatographic Stationary Phasesmentioning

confidence: 99%

Recent advances in metal‐organic frameworks and covalent organic frameworks for sample preparation and chromatographic analysis

Wang

2017

Electrophoresis

111

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“…Xu et al. also developed an in situ layer‐by‐layer self‐assembly approach to fabricate MIL‐100(Fe) coated capillary columns for the separation of aromatic acids and anilines and homochiral MOF AlaZnCl coated capillary columns for enantioseparation of four monoamine neurotransmitters and two amine drugs . Subsequently, the same group developed an even simpler and faster manufacturing method in order to improve reproducibility and to expand the application of MOF OT‐CEC columns .…”

Section: Nanomaterials Applications In Capillary Electrochromatographymentioning

confidence: 99%

“…This method consisted in the use of ZnO NPs as nucleating in the preparation of homochiral MOF [Zn(s‐nip) 2 ] n to reduce considerably the synthesis time. In comparison with the previous works in which not less than 15 h were necessary , this method was carried out in 5 h. The synthesized column was applied to the enantioseparation of epinephrine, isoprenaline and synephrine enantiomers and the isomers of nitrophenols and analogs of bisphenols, obtaining moderate resolution and efficiency and well stability and reproducibility. Finally, the enantioseparation performance of the [Zn(s‐nip) 2 ] n coated OT column using ZnO NPs as nucleating agent was compared with the [Zn(s‐nip) 2 ] n coated OT columns fabricated by the layer‐by‐layer self‐assembly and the off‐line methods.…”

Section: Nanomaterials Applications In Capillary Electrochromatographymentioning

confidence: 99%

Recent applications of nanomaterials in capillary electrophoresis

et al. 2017

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Nanomaterials have found an important place in Analytical Chemistry and, in particular, in Separation Science. Among them, metal-organic frameworks, magnetic and non-magnetic nanoparticles, carbon nanotubes and graphene, as well as their combinations, are the most important nanomaterials that have been used up to now. Concerning capillary electromigration techniques, these nanomaterials have also been used as both pseudostationary phases in electrokinetic chromatography (EKC) and as stationary phases in microchip capillary electrophoresis (CE) and capillary electrochromatography (CEC), as a result of their interesting and particular properties. This review article pretends to provide a general and critical revision of the most recent applications of nanomaterials in this field (period 2010-2017).

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“…By exploiting LbL approaches, Pédehontaa‑Hiaa and coworkers have prepared polyelectrolyte multilayers using the cationic polymer, trimethylammonium‐β‐cyclodextrin (CD), and the anionic polymers poly(sodium 4‐styrenesulfonate), polycarboxymethyl‐β‐CD or chondroitin sulfate . LbL methods have also been used by Pan and coworkers to fabricate homochiral MOFs , while Bao and coworkers have produced a face‐centered cubic MOF material . Figure shows the method of Xu et al.…”

Section: Preparation Approaches For Ot‐cec Coatingsmentioning

confidence: 99%

“…MOFs derived from enantiomerically pure building blocks can be assembled to form homochiral 3D frameworks where chiral recognition is believed to occur. Fei and coworkers have used d ‐camphoric acid whilst Pan and coworkers have used l ‐alanine as such building blocks.…”

Section: Modes Of Separationmentioning

confidence: 99%

Open tubular‐capillary electrochromatography: Developments and applications from 2013 to 2015

et al. 2016

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Open tubular CEC (OT-CEC) separates analyte mixtures by a combination of electrophoretic, electro-osmotic, and/or chromatographic effects. OT-CEC research is an active and growing field, with studies encompassing a wide range of investigations related to new strategies for chemical modification of the inner surface of the capillary, leading to the introduction of novel stationary phase coatings. This review has examined the literature on OT-CEC from 2013 to August 2015 and highlights the developments in the fabrication of highly selective stationary phases, based on materials that include cyclodextrin chiral selectors, graphene and graphene oxide, metal-organic frameworks, molecularly imprinted polymers, nanoparticles, nanolatex particles, nanocomposites, in situ generated polymers, block polymers, tentacle-type polymers, polyelectrolyte multilayers, polysaccharides, phospholipids, and proteins. This review, while considering the development of novel OT-CEC coating materials, specifically examines different immobilization or coating methodologies and approaches and also discusses the separation mechanisms that occur with these new materials. These OT-CEC coatings are intended mainly to separate low molecular weight molecules relevant to the pharmaceutical, agricultural, and food industries as well as for use in environmental monitoring.

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In situ synthesis of homochiral metal–organic framework in capillary column for capillary electrochromatography enantioseparation

Cited by 75 publications

References 43 publications

Recent advances in metal‐organic frameworks and covalent organic frameworks for sample preparation and chromatographic analysis

Recent advances in metal‐organic frameworks and covalent organic frameworks for sample preparation and chromatographic analysis

Recent applications of nanomaterials in capillary electrophoresis

Open tubular‐capillary electrochromatography: Developments and applications from 2013 to 2015

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