2016
DOI: 10.1039/c6ra10258a
|View full text |Cite
|
Sign up to set email alerts
|

In situ synthesis of magnetic poly(N-tert-butyl acrylamide-co-acrylic acid)/Fe3O4 nanogels for magnetic resonance imaging

Abstract: Poly(N-tert-butylacrylamide-co-acrylic acid)/Fe 3 O 4 (P(TBA-co-AA)/Fe 3 O 4 ) nanogels have been synthesized successfully by two steps: firstly, poly(N-tert-butylacrylamide-co-acrylic acid) (P(TBA-co-AA)) nanogels were synthesized through emulsion precipitation polymerization by using N-tertbutylacrylamide (TBA) and acrylic acid (AA) as reactive monomers; then P(TBA-co-AA)/Fe 3 O 4 nanogels were synthesized by in situ oxidation of Fe 2+ into Fe 3 O 4 nanoparticles inside the networks of the P(TBA-co-AA) nanog… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
3
0

Year Published

2016
2016
2024
2024

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

citations
Cited by 8 publications
(3 citation statements)
references
References 36 publications
0
3
0
Order By: Relevance
“…First, the maximum tolerated dose of the MNGs was studied in healthy NMRI nude mice to evaluate sufficient doses and short-term toxicity. Five doses with increasing amounts of MNG (10,20,40,70, and 100 mg kg −1 ) were injected intravenously through the tail vein and the mice were observed for 15 days. Since there were no signs of compound-related toxicity, five extra injections of 100 mg kg −1 were performed for five consecutive days to reach a total accumulated dose of 500 mg kg −1 .…”
Section: Nir-triggered Chemotherapy Evaluation In Vivomentioning
confidence: 99%
See 1 more Smart Citation
“…First, the maximum tolerated dose of the MNGs was studied in healthy NMRI nude mice to evaluate sufficient doses and short-term toxicity. Five doses with increasing amounts of MNG (10,20,40,70, and 100 mg kg −1 ) were injected intravenously through the tail vein and the mice were observed for 15 days. Since there were no signs of compound-related toxicity, five extra injections of 100 mg kg −1 were performed for five consecutive days to reach a total accumulated dose of 500 mg kg −1 .…”
Section: Nir-triggered Chemotherapy Evaluation In Vivomentioning
confidence: 99%
“…These range from a simple mixture of MNPs and nanogel suspensions 20,32,37 to the in situ synthesis of nanogels in the presence of a solution of MNPs, 35,38,39 or vice versa by the in situ synthesis of MNPs in a nanogel dispersion. 40,41 However, the non-covalent incorporation methods have important drawbacks like the desorption of the MNPs or the aggregation of the particles inside the nanogels that affects both the magnetic properties of the composites and the drug loading capacity of the systems.…”
Section: Introductionmentioning
confidence: 99%
“…In this study, compared with our group's previous work, monodisperse IPN NGs composed of poly(N‐isopropylacrylamide) (PNIPAM) and poly (methacrylic acid) (PMAA) interpenetrating networks were prepared by emulsion precipitation polymerization method, and then Fe 3 O 4 NPs were incorporated into IPN matrix by in‐situ oxidation‐reduction precipitation method. The as‐prepared monodisperse magnetic NGs were sensitive to temperature, pH, and magnetic field, respectively.…”
Section: Introductionmentioning
confidence: 99%