In-situ synthesis silver nanoparticles in chitosan/Bletilla striata polysaccharide composited microneedles for infected and susceptible wound healing

Yang, Xiao Feng; Jia, Mengqi; Li, Zheng; Ma, Zihao; Lv, Jinying; Jia, Duowuni; He, Dengfeng; Zeng, Rui; Luo, Gaoxing; Yu, Yunlong

doi:10.1016/j.ijbiomac.2022.06.131

Cited by 43 publications

(24 citation statements)

References 35 publications

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“…The HAMA MNs could maintain the activity of ADSCs over 90% for 24 h, enhance the biological function of ADSCs to secret growth factor and promote diabetic wound healing by accelerating vascularization, tissue regeneration and collagen deposition. In addition, mature biofilms form a protective microenvironment to hinder the penetration of antimicrobial substances, while MNs can effectively penetrate biofilms [ 29 , [73] , [74] , [75] , [76] ]. However, for MNs, effective drug delivery to thin tissues with little background support (e.g., the cornea) has been a challenge.…”

Section: Design Principles Of Functional Mns For Istrmentioning

confidence: 99%

Microneedles for in situ tissue regeneration

Long¹,

Ji²,

Hu³

et al. 2023

Materials Today Bio

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Section: Design Principles Of Functional Mns For Istrmentioning

confidence: 99%

Microneedles for in situ tissue regeneration

Long¹,

Ji²,

Hu³

et al. 2023

Materials Today Bio

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“…So, it is necessary to rely on greener silver-loaded nanoparticle technology to achieve antibacterial purposes. Yang et al [65] prepared chitosan (CS)/spp. albican (BSP) composite MNs by stepwise centrifugation.…”

Section: Multifunctional Microneedlesmentioning

confidence: 99%

Functional Microneedle Patch for Wound Healing and Biological Diagnosis and Treatment

Wang,

Zong,

et al. 2023

Macromolecular Bioscience

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Wound healing, especially chronic wounds, has been one of the major challenges in the field of biomedicine. Drug therapy alone is not effective, so a variety of functional wound healing dressings have been developed. Microneedles have attracted more and more attentions in the field of wound healing dressings due to their penetration and high drug delivery efficiency. In this review, all the studies on the application of microneedles in wound healing in recent years are summarized, classify different microneedles according to their functions in the process of wound healing, discuss the current challenges in the transformation of microneedle technology toward clinical applications, and finally look forward to the future design and development directions of microneedles in this field.

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“…We mention that the results are at the single molecule level and effect of aggregation may also be interested in the experimental observations 60 and is important to consider in future studies. Similarly, single Ag atom or ion is different from nanoparticles, [61][62][63][64][65][66][67] which have different properties. Nevertheless, the DFT results can serve as an important input to build force field for dynamics simulations [68][69] that are necessary for a better understanding of the processes.…”

Section: Uv Vis Spectra Band Gaps and Molecular Orbitals Of Interacti...mentioning

confidence: 99%

Theoretical studies of the interaction between silver and lipids present in HepG2 cells

Ubaldo

Wang

2022

Preprint

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We performed DFT and TDDFT calculations to determine interactions between silver atom and model cell membrane of human hepatocellular carcinoma (HepG2) cells or human liver cells. Specifically, we chose the two major lipid constituents of HepG2 cells which are 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyI-sn-glycero-3-phosphoethanolamine (POPE) to represent HepG2 cell membrane. Silver atom (Ag0) and silver ion (Ag+) are used as silver models to represent possible point-to-point interaction and the effect of silver ion (Ag+) leakage. The results show that exposure of POPC to silver ion (Ag+) at a high concentration can cause structural conformational changes from being originally bent to straight conformation. In addition, the interaction between silver ion (Ag+) and the lipids can cause significant amount of charge transfer that ranges from 0.14 to 0.16 for POPC and 0.12 to 0.14 for POPE. Moreover, though silver ion (Ag+) binds three to five times stronger to the lipids than silver atom (Ag0), both interactions are Van der Waals interaction. Finally, the presence of silver atom (Ag0) in the lipids can be detected using UV-Vis spectrophotometer by occurrence of a red shift which is seen at 376 nm and 372 nm for POPC and POPE respectively. However, detecting silver ion (Ag+) using this method is not feasible as no apparent shifts are shown.

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In-situ synthesis silver nanoparticles in chitosan/Bletilla striata polysaccharide composited microneedles for infected and susceptible wound healing

Cited by 43 publications

References 35 publications

Microneedles for in situ tissue regeneration

Microneedles for in situ tissue regeneration

Functional Microneedle Patch for Wound Healing and Biological Diagnosis and Treatment

Theoretical studies of the interaction between silver and lipids present in HepG2 cells

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