In situ thermosensitive Tamoxifen citrate loaded hydrogels: An effective tool in breast cancer loco-regional therapy

Shaker, Dalia S.; Shaker, Mohamed A.; Klingner, Anke; Hanafy, Mahmoud S.

doi:10.1016/j.jddst.2016.05.007

Cited by 28 publications

(22 citation statements)

References 42 publications

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“…This method allows a more manageable sample preparation because, it is easy to prepare P407 solutions at 20–30% ( w / w ) characterized by a liquid state at a temperature of 4–5 °C; the solution becomes a gel at room temperature [ 6 ]. Various active compounds can be entrapped within the described formulations, obtaining innovative delivery systems [ 76 , 79 , 80 , 81 , 82 , 83 , 84 , 85 ].…”

Section: Poloxamersmentioning

confidence: 99%

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

et al. 2018

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Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) between the two hydrophilic units of polyoxyethylene (POE). Poloxamer 407-based hydrogels exhibit an interesting reversible thermal characteristic. That is, they are liquid at room temperature, but they assume a gel form when administered at body temperature, which makes them attractive candidates as pharmaceutical drug carriers. These systems have been widely investigated in the development of mucoadhesive formulations because they do not irritate the mucosal membranes. Based on these mucoadhesive properties, a simple administration into a specific compartment should maintain the required drug concentration in situ for a prolonged period of time, decreasing the necessary dosages and side effects. Their main limitations are their modest mechanical strength and, notwithstanding their bioadhesive properties, their tendency to succumb to rapid elimination in physiological media. Various technological approaches have been investigated in the attempt to modulate these properties. This review focuses on the application of poloxamer 407-based hydrogels for mucosal drug delivery with particular attention being paid to the latest published works.

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Section: Poloxamersmentioning

confidence: 99%

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

et al. 2018

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“…After intra- or peritumoral injection, such systems, in a sol-state before administration, turn into hydrogels in response to certain stimuli and locally release the drug in a controlled manner. The increase in drug concentration at the target site (tumor) maximizes the anticancer activity and, at the same time, minimizes the systemic toxicity; moreover, the hydrogel three-dimensional structure ensures a sustained drug release that prolongs the tumor exposure time to the chemotherapeutic agent [ 100 , 101 ]. In particular, a deep review of the literature suggested that a certain number of published papers were focused on the use of in situ gelling systems in the local treatment of bladder cancer.…”

Section: Intravesical Routementioning

confidence: 99%

Recent Advances in the Development of In Situ Gelling Drug Delivery Systems for Non-Parenteral Administration Routes

et al. 2020

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In situ gelling drug delivery systems have gained enormous attention over the last decade. They are in a sol-state before administration, and they are capable of forming gels in response to different endogenous stimuli, such as temperature increase, pH change and the presence of ions. Such systems can be administered through different routes, to achieve local or systemic drug delivery and can also be successfully used as vehicles for drug-loaded nano- and microparticles. Natural, synthetic and/or semi-synthetic polymers with in situ gelling behavior can be used alone, or in combination, for the preparation of such systems; the association with mucoadhesive polymers is highly desirable in order to further prolong the residence time at the site of action/absorption. In situ gelling systems include also solid polymeric formulations, generally obtained by freeze-drying, which, after contact with biological fluids, undergo a fast hydration with the formation of a gel able to release the drug loaded in a controlled manner. This review provides an overview of the in situ gelling drug delivery systems developed in the last 10 years for non-parenteral administration routes, such as ocular, nasal, buccal, gastrointestinal, vaginal and intravesical ones, with a special focus on formulation composition, polymer gelation mechanism and in vitro release studies.

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“…In vivo lung cancer xenograft model tests showed that PDMP could inhibit tumor growth and prolong survival in tumor-bearing BALB/c nude mice with longer survival time (53 days versus 40 days in the free DDP þ PTX group, 26 days in the blank control group and 25 days in the normal saline group). Shaker et al (2016) prepared tamoxifen citrate liposomes by membrane hydration technology, and incorporated them into Planck's thermosensitive hydrogel by cold method. Planck's thermosensitive hydrogel was composed mainly of poloxamer, a kind of polymer nonionic surfactant, polyoxyethylene ether block copolymer, and the gelation temperature of the hydrogel system can be modified to optimal gelation at physiological temperature (34-37 C) by changing the type and composition of the poloxamer (such as poloxamer 188 or 407).…”

Section: Ph-sensitive In Situ Hydrogelmentioning

confidence: 99%

“…Tumors are one type of the malignant diseases that threaten human health most. With the aging of the world's population and changing in living environment and daily habits, the number of people died from tumors has been increasing dramatically every year, and the world has fallen into conflict with the terrible war of tumors (Shaker et al, 2016;Siegel et al, 2019;Feng et al, 2019). The treatment of tumors has become an important task for medical researchers.…”

Section: Introductionmentioning

confidence: 99%

Research progress in the application of in situ hydrogel system in tumor treatment

Wei

Yin

et al. 2020

Drug Delivery

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The in situ hydrogel drug delivery system is a hot research topic in recent years. Combining both properties of hydrogel and solution, in situ hydrogels can provide many advantages for drug delivery application, including easy application, high local drug concentration, prolonged drug retention time, reduced drug dose in vivo, good biocompatibility and improved patient compliance, thus has potential in tumor treatment. In this paper, the related literature reports in recent years were reviewed to summarize and discuss the research progress and development prospects in the application of in situ hydrogels in tumor treatment. ARTICLE HISTORY

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In situ thermosensitive Tamoxifen citrate loaded hydrogels: An effective tool in breast cancer loco-regional therapy

Cited by 28 publications

References 42 publications

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

Recent Advances in the Development of In Situ Gelling Drug Delivery Systems for Non-Parenteral Administration Routes

Research progress in the application of in situ hydrogel system in tumor treatment

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