In the search of active nanocarriers for delivery of mitomycin C drug

Mohajeri, Afshan; Amigh, Soode

doi:10.1039/d0ma00018c

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…The intrinsic antitumor and antimicrobial properties of chitosan have attracted interest in enhancing the efficacy of corresponding loaded substances [23,30]. To put the antitumor potential of this material to use, particular attention has been drawn to the delivery of a plethora of anti-cancer drugs [28] such as doxorubicin [31,32], paclitaxel [33][34][35][36], docetaxel [33,37,38], tamoxifen [39,40], curcumin [40][41][42][43], cisplatin [44,45], and mitomycin C [46,47]. The resulting nanosystems are able to reduce side toxicity while increasing treatment efficiency [28].…”

Section: Natural Polymers 211 Chitosanmentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

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Section: Natural Polymers 211 Chitosanmentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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“…BNNTs have a central channel that could be loaded with growth factors, which can gradually diffuse depending on the magnitude of interactions between the growth factor and the BNNT walls. Several computational studies have been performed for understanding the potential of BNNTs to serve as a carrier for delivering various anti-cancer drugs like carboplatin [104,105], 5-aminolevulinic acid [106], tegafur [107], 5-fluorouracil [108,109], mitomycin C [110], gemcitabine [111], docetaxel [112], hydroxyurea [113], amino-derived platinum complex [114], pro-carbazine [115], floxuridine [116] and amino acids. Molecular dynamics (MD) and density-functional theory techniques provide insights on the adsorption of the drugs inside and outside the nanotubes by varying parameters like chirality, diameter, length and temperature.…”

Section: Potential Role Of Bnnts As a Growth Factor Delivery Systemmentioning

confidence: 99%

Boron nitride nanotube scaffolds: emergence of a new era in regenerative medicine

Anandhan

Krishnan

2021

Biomed. Mater.

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Tissue engineering scaffolds have transformed from passive geometrical supports for cell adhesion, extension and proliferation to active, dynamic systems that can in addition, trigger functional maturation of the cells in response to external stimuli. Such ‘smart’ scaffolds require the incorporation of active response elements that can respond to internal or external stimuli. One of the key elements that direct the cell fate processes is mechanical stress. Different cells respond to various types and magnitudes of mechanical stresses. The incorporation of a pressure-sensitive element in the tissue engineering scaffold therefore, will aid in tuning the cell response to the desired levels. Boron nitride nanotubes (BNNTs) are analogous to carbon nanotubes and have attracted considerable attention due to their unique amalgamation of chemical inertness, piezoelectric property, biocompatibility and, thermal and mechanical stability. Incorporation of BNNTs in scaffolds confers them with piezoelectric property that can be used to stimulate the cells seeded on them. Biorecognition and solubilization of BNNTs can be engineered through surface functionalization with different biomolecules. Over the years, the importance of BNNT has grown in the realm of healthcare nanotechnology. This review discusses the salient properties of BNNTs, the influence of functionalization on their in vitro and in vivo biocompatibility, and the uniqueness of BNNT-incorporated tissue engineering scaffolds.

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“…6 Accordingly, increasing effort is being devoted to designing and constructing multifunctional nano-scale drug delivery systems (DDSs) having the potential of efficient drug loading, controlled drug release, maximum efficiency, and minimum side effects. 7,8 In recent years, various carbonic and non-carbonic materials such as polymeric nanoparticles (PNPs), 9 boron nitride nanotubes (BNNTs), 10 silica particles, 11 gold nanoparticles, 12 quantum dots, 13 carbon nanotubes, 14 and graphene 15 have been suggested as efficient carriers for different drugs. Among these, carbon-based nanomaterials have attracted great attention which is due to the specific physicochemical properties that can be tuned by altering their composition, dimension, and shape.…”

Section: Introductionmentioning

confidence: 99%