This paper studies the countermeasures for the construction of a Think Tank in Guangdong province, aiming to provide intellectual support for Guangdong province in the development of the Guangdong-Hong Kong-Macao Greater Bay Area, and to help the development of Guangdong Province.[Method/process] This paper adopts a questionnaire survey, field investigation, interview method, the construction of Guangdong think-tank status , and the recent planning survey, after information collection and statistical analysis, learned that the Guangdong think-tank construction management system mechanism is immature, think-tank alone, lack of coordination, all kinds of think-tank decision-making research has a certain degree of limitations, the think-tank achievement conversion rate is low.[Results / Conclusion] This paper puts forward the strategy of building a Think Tank in Guangdong from the aspects of strengthening the top-level system design, building a Guangdong Think Tank alliance, innovating the construction of information resources, and strengthening the construction of a talent team.