Mixed methods researchers who make a commitment to use their work for social betterment take a stance that has implications for their designs. This article contributes to mixed methods by illustrating how designs informed by the transformative and Indigenous paradigms provide examples of both the value of pursuing this goal, as well as the challenges that mixed methods researchers face. Social betterment studies engage with marginalized and vulnerable populations, such as Indigenous nations, people with disabilities, women and girls, and sexual minorities. Insights from the transformative and Indigenous paradigms are provided and illustrated by mixed methods studies. Challenges are discussed along with resources that can help address these challenges.