In-Transit Metastasis from Primary Cutaneous Squamous Cell Carcinoma in a Nonimmunosuppressed Patient

Kocatürk, Emek; Ülkümen, Pelin Kuteyla; Kızıltaç, Utkan; Yüksel, Tülin; Kunter, Ayşe Seza; Erhan, Selma Şengiz

doi:10.2310/7750.2014.14047

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Our patient fulfilled all these diagnostic criteria, although his primary tumor was moderately differentiated while the metastatic disease was poorly differentiated in nature. Other cases have also similarly reported worsening tumor differentiation at the site of the in-transit metastasis compared to the primary tumor [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

In-Transit Metastasis of Cutaneous Squamous Cell Carcinoma With Lymphovascular Invasion in an Immunocompetent Patient

Stewart¹,

Ahn²,

Brewer³

2022

Cureus

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In-transit metastases of melanoma and non-melanoma skin cancers are metastases located in the skin or subcutaneous tissue between the primary tumor and the nearest nodal basin. Although rare, in-transit cutaneous squamous cell carcinoma (SCC) is an emerging diagnosis in immunocompromised and immunocompetent patients that may have significant implications on treatment and prognosis. Lymphovascular invasion is an uncommon high-risk feature of SCC. Here, we present a case of a 73-year-old non-immunosuppressed man with no previous history of skin cancer, found to have in-transit metastasis with lymphovascular invasion during Mohs surgery for a primary SCC of his right ear. Patients with in-transit SCC should receive further staging imaging and a multimodal approach to treatment, including Mohs micrographic surgery, adjuvant radiation, and possibly sentinel lymph node biopsy and immunotherapy or chemotherapy.

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Section: Discussionmentioning

confidence: 99%

In-Transit Metastasis of Cutaneous Squamous Cell Carcinoma With Lymphovascular Invasion in an Immunocompetent Patient

Stewart¹,

Ahn²,

Brewer³

2022

Cureus

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“…Prognosis was poor with 5-year overall survival of 13%. 12 Important to have a low index of suspicion when evaluating new skin lesions in elderly / immunocompromised patients. Subcutaneous SCCs may be a sign of cutaneous or extracutaneous metastasis and are particularly aggressive and recurrent, it is important to treat such cancers aggressively to optimize patient outcomes.…”

Section: Discussionmentioning

confidence: 99%

In- transit metastasis: Case report of a rare phenomenon in primary cutaneous squamous cell carcinoma

K¹,

Sathi²,

Ramakrishnan³

et al. 2022

JDPO

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Metastatic foci situated in dermal or subcutaneous tissue without the involvement of overlying skin, between the closest lymph node and primary tumor is called in transit metastasis. Although in transit metastasis has been commonly described in malignant melanoma, there are rare cases of squamous cell carcinomas, presenting with the same. It is an uncommon form of metastasis through lymphatics and is found in immunocompromised individuals. We present a case report of squamous cell carcinoma, presenting in an elderly male, as multiple nodules beneath skin. With this case, we highlight the variety of forms of spread in cutaneous squamous cell carcinoma and its prognostic importance.

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“…This disease entity was subsequently reported among immunocompetent patients. [13][14][15][16] Within the head and neck region these can occur in either the parotid basin or cervical region. STM is now known to occur in a variety of malignancies including melanoma (in-transit metastases) 17 and mucosal squamous cell carcinoma of the head and neck, 18 however, there is little known about their prognostic significance in head and neck cutaneous squamous cell carcinoma (HNcSCC).…”

Section: Introductionmentioning

confidence: 99%

Soft Tissue Metastases in Head and Neck Cutaneous Squamous Cell Carcinoma

et al. 2020

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ObjectiveSoft tissue metastases (STM) in head and neck cutaneous squamous cell carcinoma (HNcSCC) are non‐nodal based metastases to the parotid and cervical soft tissues of the head and neck. This is a unique subgroup of regional metastases amongst patients with cSCC and have been shown to be associated with poor prognosis. Detailed studies of this subgroup are lacking in the literature. A retrospective cohort analysis was performed to characterize the prognostic significance of STM in HNcSCC based on individual clinicopathological features.MethodsPatients with HNcSCC with STM were identified from the Sydney Head and Neck Cancer Institute database. Clinicopathological characteristics were extracted from the histopathological reports. Recurrence and follow‐up data were analyzed to determine disease‐free and overall survival using the Kaplan–Meier method and Cox proportional hazards models.ResultsAfter excluding all patients with lymph node metastasis with no STM, there were 200 patients identified (161 parotid, 32 cervical, and seven with concurrent parotid and cervical STM) with a 5‐year overall survival of 36%. In univariable analysis, age of patients, size of the deposits, location of the deposits, and patients that were not offered adjuvant radiotherapy have worse overall survival. However, on multivariable analysis, age and the number of STM deposits were independent factors that predict for worse survival.ConclusionThe presence of STM in patients with HNcSCC is associated with poor prognosis. Increasing number of STM deposits, as well as involved margin of the regional excision, negatively impacted on the overall prognosis.Level of EvidenceLevel III – retrospective cohort study. Laryngoscope, 131:E1209–E1213, 2021

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In-Transit Metastasis from Primary Cutaneous Squamous Cell Carcinoma in a Nonimmunosuppressed Patient

Abstract: We present a case of in-transit metastasis in a nonimmunosuppressed patient with a primary cutaneous squamous cell carcinoma.

Cited by 5 publications

References 19 publications

In-Transit Metastasis of Cutaneous Squamous Cell Carcinoma With Lymphovascular Invasion in an Immunocompetent Patient

In-Transit Metastasis of Cutaneous Squamous Cell Carcinoma With Lymphovascular Invasion in an Immunocompetent Patient

In- transit metastasis: Case report of a rare phenomenon in primary cutaneous squamous cell carcinoma

Soft Tissue Metastases in Head and Neck Cutaneous Squamous Cell Carcinoma

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