In utero and postnatal haemopoietic tissue doses resulting from maternal ingestion of strontium isotopes from the Techa river

Shagina, N. B.; Толстых, Е. И.; Fell, Timothy; Harrison, John; Phipps, A. W.

doi:10.1093/rpd/ncm357

Cited by 11 publications

(15 citation statements)

References 14 publications

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“…Years after the exposure ended, 90 Sr could be detected in the skeletons of their fetuses, which could only have come from resorption of 90 Sr that had been previously fixed in the maternal skeleton (921,922). But women who ingested 90 Sr during pregnancy, especially during the third trimester, gave birth to babies with 10-fold higher 90 Sr content, consistent with dietary absorption of mineral being responsible for much more of the mineral content of the fetal skeleton (819,921,922).…”

Section: Human Datamentioning

confidence: 84%

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs

2016

Physiological Reviews

384

524

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During pregnancy and lactation, female physiology adapts to meet the added nutritional demands of fetuses and neonates. An average full-term fetus contains ϳ30 g calcium, 20 g phosphorus, and 0.8 g magnesium. About 80% of mineral is accreted during the third trimester; calcium transfers at 300-350 mg/day during the final 6 wk. The neonate requires 200 mg calcium daily from milk during the first 6 mo, and 120 mg calcium from milk during the second 6 mo (additional calcium comes from solid foods). Calcium transfers can be more than double and triple these values, respectively, in women who nurse twins and triplets. About 25% of dietary calcium is normally absorbed in healthy adults. Average maternal calcium intakes in American and Canadian women are insufficient to meet the fetal and neonatal calcium requirements if normal efficiency of intestinal calcium absorption is relied upon. However, several adaptations are invoked to meet the fetal and neonatal demands for mineral without requiring increased intakes by the mother. During pregnancy the efficiency of intestinal calcium absorption doubles, whereas during lactation the maternal skeleton is resorbed to provide calcium for milk. This review addresses our current knowledge regarding maternal adaptations in mineral and skeletal homeostasis that occur during pregnancy, lactation, and post-weaning recovery. Also considered are the impacts that these adaptations have on biochemical and hormonal parameters of mineral homeostasis, the consequences for long-term skeletal health, and the presentation and management of disorders of mineral and bone metabolism.

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Section: Human Datamentioning

confidence: 84%

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs

2016

Physiological Reviews

384

524

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“…An additional complication is that dosimetric models currently consider average doses to RBM and do not take account of peripheral alpha particle irradiation from radionuclides deposited in bone and the location of different populations of haemopoietic stem cells within the marrow (Harrison 2009). Even more complex is the calculation of in utero haemopoietic doses, since it is well established that there are multiple and changing sites of haemopoiesis during early development before the RBM becomes established as the predominant site (Shagina et al 2007). Nevertheless, the contribution to equivalent dose from low LET radiation is larger than that from high LET and this will reduce uncertainties in the total equivalent dose to RBM.…”

Section: Summary and Discussionmentioning

confidence: 99%

Dose to red bone marrow of infants, children and adults from radiation of natural origin

Kendall

Fell²,

Harrison³

2009

J. Radiol. Prot.

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Natural radiation sources contribute much the largest part of the radiation exposure of the average person. This paper examines doses from natural radiation to the red bone marrow, the tissue in which leukaemia is considered to originate, with particular emphasis on doses to children. The most significant contributions are from x-rays and gamma rays, radionuclides in food and inhalation of isotopes of radon and their decay products. External radiation sources and radionuclides other than radon dominate marrow doses at all ages. The variation with age of the various components of marrow dose is considered, including doses received in utero and in each year up to the age of 15. Doses in utero include contributions resulting from the ingestion of radionuclides by the mother and placental transfer to the foetus. Postnatal doses include those from radionuclides in breast-milk and from radionuclides ingested in other foods. Doses are somewhat higher in the first year of life and there is a general slow decline from the second year of life onwards. The low linear energy transfer (LET) component of absorbed dose to the red bone marrow is much larger than the high LET component. However, because of the higher radiation weighting factor for the latter it contributes about 40% of the equivalent dose incurred up to the age of 15.

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“…Evaluation of the intake of this radionuclide with breast milk should take into account the volume of breast milk consumed, 90 Sr concentration in breast milk, and the period of breastfeeding. Assessment of these parameters and development of the biokinetic model for strontium transfer to breast milk were implemented under a European Union-funded project and are described in Shagina et al (2007). One of the parameters required for estimation of 90 Sr intake with breast milk in the Techa River settlements is the intake with maternal diet; i.e., the reference 90 Sr-intake function evaluated in this study.…”

Section: Assessment Of 90 Sr Intake Function For Residents Of Muslyummentioning

confidence: 99%

Reconstruction of Long-Lived Radionuclide Intakes for Techa Riverside Residents: Strontium-90

Толстых¹,

Дегтева²,

Peremyslova³

et al. 2011

Health Physics

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Releases of radioactive materials from the Mayak Production Association in 1949-1956 resulted in contamination of the Techa River; a nuclide of major interest was 90Sr, which downstream residents consumed with water from the river and with milk contaminated by cows' consumption of river water and contaminated pasture. Over the years, several reconstructions of dose have been performed for the approximately 30,000 persons who make up the Extended Techa River Cohort. The purpose of the study described here was to derive a revised reference-90Sr-intake function for the members of this cohort. The revision was necessary because recently discovered data have provided a more accurate description of the time course of the releases, and more is now known about the importance of the pasture grass-cow-milk pathway for the members of this cohort. The fundamental basis for the derivation of the reference-90Sr-intake function remains the same: thousands of measurements of 90Sr content in bone with a special whole-body counter, thousands of measurements of beta-activity of front teeth with a special tooth-beta counter, and a variety of other measurements, including post mortem measurements of 90Sr in bone, measurements of 90Sr in cow's milk, and measurements of beta activity in human excreta. Results of the new analyses are that the major intake started in September 1950 and peaked somewhat later than originally postulated. However, the total intake for adult residents has not changed significantly. For children of some birth years, the intake and incorporation of Sr in bone tissue have changed substantially.

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In utero and postnatal haemopoietic tissue doses resulting from maternal ingestion of strontium isotopes from the Techa river

Cited by 11 publications

References 14 publications

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Dose to red bone marrow of infants, children and adults from radiation of natural origin

Reconstruction of Long-Lived Radionuclide Intakes for Techa Riverside Residents: Strontium-90

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