In-utero antibiotic exposure and subsequent infections in infancy: a register-based cohort study with sibling analysis

Nakitanda, Aya Olivia; Kieler, Helle; Odsbu, Ingvild; Rhedin, Samuel; Almqvist, Catarina; Pasternak, Björn; Pazzagli, Laura

doi:10.1016/j.ajogmf.2023.100860

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…Maternal supplementation with Lactobacillus murinus HU-1 alleviated MMD-induced abnormalities in microglia and social behavior in offspring ( Lebovitz et al, 2019 ). This result has been confirmed in clinical trials showing that prenatal antibiotic exposure during fetal delivery may increase the risk of various postpartum infection incidents ( Nakitanda et al, 2023 ). Therefore, whether it is a GF or an antibiotic-treated animal, the morphology and function of microglia will be disturbed, which fully illustrates the regulation of the intestinal microbiota in microglia.…”

Section: Microglia Play An Important Role In Gut–brain Interactionsmentioning

confidence: 60%

“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction

Zheng

Zhang

et al. 2023

Protein &Amp; Cell

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Abnormal brain-gut interaction is considered the core pathological mechanism behind the disorders of gut-brain interaction, in which the intestinal microbiota plays an important role. Microglia are the “sentinels” of the central nervous system, which participate in tissue damage caused by traumatic brain injury, resist central infection and participate in neurogenesis, and are involved in the occurrence of various neurological diseases. With in-depth research on disorders of gut-brain interaction, we could find an interaction between the intestinal microbiota and microglia and that they are jointly involved in the occurrence of disorders of gut-brain interaction, especially in individuals with comorbidities of mental disorders, such as irritable bowel syndrome. This bidirectional regulation of microbiota and microglia provides a new direction for the treatment of disorders of gut-brain interaction. In this review, we focus on the role and underlying mechanism of the interaction between gut microbiota and microglia in disorders of gut-brain interaction, especially irritable bowel syndrome, and the corresponding clinical application prospects and highlight its potential to treat disorders of gut-brain interaction in individuals with psychiatric comorbidities.

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Section: Microglia Play An Important Role In Gut–brain Interactionsmentioning

confidence: 60%

“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction

Zheng

Zhang

et al. 2023

Protein &Amp; Cell

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“…Importantly, antibiotic treatment during labor may alter the disease course and potentially protect the fetus from acquiring bacterial infections. However, in utero exposure to antibiotics may also increase the child's susceptibility to childhood infections [37]. In the case of chorioamnionitis during labor, and specifically in term fetuses, we speculate that the very brief exposure to antibiotics produces a negligible effect on the long-term infectious morbidity of these children.…”

Section: Discussionmentioning

confidence: 85%

The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring

Davidi,

Gutvirtz,

Sheiner

2024

JCM

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Background: Chorioamnionitis during labor exposes the fetus to an intrauterine state that may alter the future immune response and may expose the offspring to future susceptibility to infectious disease. We evaluated the long-term pediatric infectious morbidity of children born at term to mothers who have chorioamnionitis during labor. Methods: This was a population-based cohort analysis including only term singleton deliveries at a regional tertiary hospital between the years 1991 and 2021. Offspring to mothers with and without a diagnosis of chorioamnionitis during labor were compared. Offspring hospitalizations up to the age of 18 years involving infectious morbidity were evaluated using the Kaplan–Meier survival curve and a Cox regression model to control possible confounders. Results: A total of 331,598 deliveries were included, 988 (0.3%) of which were of mothers diagnosed with chorioamnionitis during labor. All infectious morbidity rates included in the analysis were comparable between groups. The Kaplan–Meier survival curves were similar for both groups (log-rank = 0.881) and the multivariable analysis ascertained that chorioamnionitis during labor was not a risk factor for offspring’s long-term infectious morbidity (HR 0.929, 95%CI 0.818–1.054, p = 0.254). Conclusions: In our cohort, term chorioamnionitis during labor was not associated with a higher risk of pediatric hospitalization due to infections. The infectious/inflammatory state during labor did not expose nor increase the susceptibility of the term offspring to future infectious morbidity.

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“…In the full cohort of 1,347,018 infants (live singletons born between 2006 and 2018), 294,657 (21.9%) were exposed to prenatal antibiotics (Nakitanda et al 2023 ). Indications for obstetric antibiotics include clinical chorioamnionitis, group B Streptococcus infection, premature rupture of fetal membranes, and prophylactic administration for premature birth (Martinez de Tejada 2014 ; (2018) 2018 ; (2020) 2020 ; Ronzoni et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Determinants of microbial colonization in the premature gut

Chen

Shi

2023

Mol Med

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Abnormal microbial colonization in the gut at an early stage of life affects growth, development, and health, resulting in short- and long-term adverse effects. Microbial colonization patterns of preterm infants differ from those of full-term infants in that preterm babies and their mothers have more complicated prenatal and postnatal medical conditions. Maternal complications, antibiotic exposure, delivery mode, feeding type, and the use of probiotics may significantly shape the gut microbiota of preterm infants at an early stage of life; however, these influences subside with age. Although some factors and processes are difficult to intervene in or avoid, understanding the potential factors and determinants will help in developing timely strategies for a healthy gut microbiota in preterm infants. This review discusses potential determinants of gut microbial colonization in preterm infants and their underlying mechanisms.

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In-utero antibiotic exposure and subsequent infections in infancy: a register-based cohort study with sibling analysis

Cited by 8 publications

References 38 publications

“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction

“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction

The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring

Determinants of microbial colonization in the premature gut

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