In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies

Feng, Haixia; Xun, Pengcheng; Pike, Katharine C.; Wills, Andrew K; Chawes, Bo; Bisgaard, Hans; Cai, Wei; Wu, Yanping; He, Ka

doi:10.1016/j.jaci.2016.06.065

Cited by 80 publications

(89 citation statements)

References 49 publications

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“…Observational studies have associated lower maternal 25(OH)D serum levels with higher risk of preeclampsia, gestational diabetes, caesarean sections, preterm birth (PTB) or IUGR [47,48]. In addition, there is growing evidence on the association with offspring risk of asthma, bone health, allergies and impaired neurodevelopment [49][50][51][52].…”

Section: Vitamin D Supplementation During Pregnancy and Perinatal Outmentioning

confidence: 99%

“…The levels of prenatal vitamin D on wheeze/asthma susceptibility in offspring have been extensively investigated in observational studies [49,50,91,92]. There are two meta-analyses that have shown high dietary vitamin D intake during pregnancy to be associated with a reduced risk of wheeze in the offspring (Nurmatov et al [91] OR 0.56, 95% CI 0.42-0.73; Beckhaus et al [92] OR 0.58, 95% CI 0.38-0.88).…”

Section: Prenatal Vitamin D Status and Asthma Riskmentioning

confidence: 99%

“…However, the results of metaanalysis from observational studies but based on maternal serum 25(OH)D concentrations on asthma/wheeze outcome are controversial yet. Two other meta-analyses showed a trend to increased 25(OH)D to be inversely associated with the risk of asthma and wheeze during childhood, although associations did not reach statistical significance [50,93]. Another meta-analysis based on 12 prospective studies suggested even a more complex association, in which a U-shaped relationship between maternal 25(OH)D levels and risk of asthma was described [49].…”

Section: Prenatal Vitamin D Status and Asthma Riskmentioning

confidence: 99%

See 2 more Smart Citations

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Larqué

Morales

Leis³

et al. 2018

Ann Nutr Metab

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Background: To what extent does the circulating 25-hydroxyvitamin D (25[OH]D) concentration help to meet the physiological needs of humans is an ongoing subject of debate. Remaining unexposed to the sun to reduce melanoma cancer risk, current lifestyle with less out door activities, and increasing obesity rates, which in turn increases the storage of vitamin D in the adipose tissue, are presumably factors that contribute to the substantial upsurge in the prevalence of vitamin D deficiency in humans. Since evidence is lacking regarding the appropriate cut-off points to define vitamin D status during pregnancy, references used to establish the intake recommendations and vitamin D content of prenatal vitamin supplements are quite conservative. Summary: The foetus depends fully on maternal 25(OH)D supply. 25(OH)D readily crosses the placenta and it is activated into 1,25(OH)₂D by foetal kidneys. Moreover, 1,25(OH)₂D can also be synthesized within the placenta to regulate placental metabolism. The importance of vitamin D during pregnancy for maintaining maternal calcium homeostasis and therefore for foetal bone development is well recognized; major discussions are in progress regarding the potential maternal detrimental effects on pregnancy outcomes, foetal development, and the long-term health of children. Interventional studies have also evaluated the effect of vitamin D for reduction on preterm birth and asthma programming. Key Messages: Clinically, by understanding the effects of vitamin D on perinatal outcomes, we could individualize antenatal counselling regarding vitamin D supplementation to ensure vitamin D repletion without increasing the risk of foetal hypercalcemia.

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Section: Vitamin D Supplementation During Pregnancy and Perinatal Outmentioning

confidence: 99%

Section: Prenatal Vitamin D Status and Asthma Riskmentioning

confidence: 99%

Section: Prenatal Vitamin D Status and Asthma Riskmentioning

confidence: 99%

See 1 more Smart Citation

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Larqué

Morales

Leis³

et al. 2018

Ann Nutr Metab

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“…Observational studies, though heterogeneous and inconsistent, and a growing body of clinical trial data suggest a protective effect of vitamin D supplementation during pregnancy and early infancy [114–117]. This and other prenatal interventions are reviewed in detail in this issue by Tina Hartert.…”

Section: Vitamin D Supplementationmentioning

confidence: 99%

Strategies to alter the natural history of childhood asthma

Lee-Sarwar

Bacharier

Litonjua

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Asthma exhibits significant heterogeneity in occurrence and severity over the lifespan. Our goal is to discuss recent evidence regarding determinants of the natural history of asthma during childhood, and review the rationale behind and status of major efforts to alter its course. Recent findings Variations in microbial exposures are associated with risk of allergic disease, and the use of bacterial lysates may be a promising preventive strategy. Exposure to air pollution appears to be particularly damaging in prenatal and early life, and interventions to reduce pollution are feasible and result in clinical benefit. E-cigarette use may have a role in harm reduction for conventional cigarette smokers with asthma, but has undefined short- and long-term effects that must be clarified. Vitamin D insufficiency over the first several years of life is associated with risk of asthma, and vitamin D supplementation reduces the risk of severe exacerbations. Summary The identification of risk factors for asthma occurrence, persistence and severity will continue to guide efforts to alter the natural history of the disease. We have reviewed several promising strategies that are currently under investigation. Vitamin D supplementation and air pollution reduction have been shown to be effective strategies and warrant increased investigation and implementation.

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“…A recent metaanalysis of 16 birth-cohort studies concluded that increased in utero exposure to 25(OH)D reduced the risk of asthma and wheezing, but not of respiratory tract infections in children [10].…”

mentioning

confidence: 99%

Vitamin D and its role in the management and prevention of lower respiratory tract infections in infants and young children

Pettifor

2016

Indian Pediatr

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In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies

Cited by 80 publications

References 49 publications

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Strategies to alter the natural history of childhood asthma

Vitamin D and its role in the management and prevention of lower respiratory tract infections in infants and young children

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