“…Global hypomethylation of germ cell DNA in F0 mice Altered testes mRNA (414 genes involved in nitric oxide and ROS pathways, Sertoli cell junction signaling, EIF2 signaling, NF-κβ signaling and inflammatory response, lipid metabolism, and carbohydrate metabolism), and sperm and testes microRNA (11 microRNAs mostly involved in metabolic disease, cell death, production of ROS, DNA replication, NF-κB signaling, p53 signaling, recombination and repair, lipid metabolism, spermatogenesis, and embryonic development) expression Mice High fat diet during pregnancy and lactation [143,170,173,175,180,186,192,195,196,198,200] Increased body weight, body fat content, inflammatory markers and serum insulin and leptin concentrations [181] Increased body weight in female mice in F1 and F2 generations (most severe in F2)…”