2021
DOI: 10.1016/j.taap.2021.115514
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In utero exposure to dipentyl phthalate disrupts fetal and adult Leydig cell development

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Cited by 11 publications
(20 citation statements)
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“…The following adrenal cortex genes: (1) regulatory growth factor and receptors ( Igf1 , Mc2r , and Agtr1a ), (2) cholesterol transporter and regulator ( Scarb1 and Star ), (3) adrenal cortex steroid biosynthetic enzymes ( Cyp11a1 , Hsd3b1 , Cyp21 , Cyp11b1 , and Cyp11b2 ), (4) CORT metabolizing enzymes ( Hsd11b1 and Hsd11b2 ), (5) transcription factors ( Nr5a1 , Nr4a1 , and Nr4a2 ), (6) antioxidants ( Sod1 , Sod2 , Gpx1 , and Cat ), and (7) house‐keeping genes ( Rps16 , Gapdh , and Actb ). Ct values were calculated at the end of each run of qPCR, and the expression level of the target mRNA was calculated using the standard curve method as described previously 29 . Since there was no statistical difference in Rps16 , Gapdh , I and Actb between groups, Rps16 was finally designated as the internal control for normalization.…”
Section: Methodsmentioning
confidence: 99%
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“…The following adrenal cortex genes: (1) regulatory growth factor and receptors ( Igf1 , Mc2r , and Agtr1a ), (2) cholesterol transporter and regulator ( Scarb1 and Star ), (3) adrenal cortex steroid biosynthetic enzymes ( Cyp11a1 , Hsd3b1 , Cyp21 , Cyp11b1 , and Cyp11b2 ), (4) CORT metabolizing enzymes ( Hsd11b1 and Hsd11b2 ), (5) transcription factors ( Nr5a1 , Nr4a1 , and Nr4a2 ), (6) antioxidants ( Sod1 , Sod2 , Gpx1 , and Cat ), and (7) house‐keeping genes ( Rps16 , Gapdh , and Actb ). Ct values were calculated at the end of each run of qPCR, and the expression level of the target mRNA was calculated using the standard curve method as described previously 29 . Since there was no statistical difference in Rps16 , Gapdh , I and Actb between groups, Rps16 was finally designated as the internal control for normalization.…”
Section: Methodsmentioning
confidence: 99%
“…Adrenal gland protein preparation and Western blotting were conducted as described previously 29 . Briefly, the lyse buffer was added to the whole adrenal gland, which was homogenized.…”
Section: Methodsmentioning
confidence: 99%
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