2014
DOI: 10.1080/15287394.2014.887426
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In Utero Exposure to Environmentally Relevant Concentrations of PCB 153 and PCB 118 Disrupts Fetal Testis Development in Sheep

Abstract: Polychlorinated biphenyls (PCB) are environmental pollutants linked to adverse health effects including endocrine disruption and disturbance of reproductive development. This study aimed to determine whether exposure of pregnant sheep to three different mixtures of PCB 153 and PCB 118 affected fetal testis development. Ewes were treated by oral gavage from mating until euthanasia (d 134), producing three groups of fetuses with distinct adipose tissue PCB levels: high PCB 153/low PCB 118 (n = 13), high PCB 118/… Show more

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Cited by 15 publications
(6 citation statements)
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“…These findings agreed with the suggestion that functional pathways could be better and reliable markers than single genes. This observation is consistent with the documented effect of several water pollutants (metals, plasticizers and others) on hormonal axes linked to reproductive health outcomes [ 60 64 ], as seen also in our experimental settings (manuscript in preparation). Here, toxicogenomics showed its predictive strength in identifying biomarkers, steroid hormones, that can be easily detected in blood, suitable for monitoring the impact of anthropogenic activities on human and identifying risks for human populations even if not indicative of specific pollutants.…”
Section: Discussionsupporting
confidence: 92%
“…These findings agreed with the suggestion that functional pathways could be better and reliable markers than single genes. This observation is consistent with the documented effect of several water pollutants (metals, plasticizers and others) on hormonal axes linked to reproductive health outcomes [ 60 64 ], as seen also in our experimental settings (manuscript in preparation). Here, toxicogenomics showed its predictive strength in identifying biomarkers, steroid hormones, that can be easily detected in blood, suitable for monitoring the impact of anthropogenic activities on human and identifying risks for human populations even if not indicative of specific pollutants.…”
Section: Discussionsupporting
confidence: 92%
“…Eight papers on potential effects of PCDD/Fs and DL‐PCBs in sheep were identified (Annex A.11.1, Table 88 therein). Three of these concerned the same study with sheep treated with PCB‐118 (Gutleb et al., ; Zimmer et al., ; Krogenaes et al., ). There was apparently a cross‐contamination with PCB‐153 and standards were not checked for the presence of more potent DL‐PCBs and PCDD/Fs.…”
Section: Assessmentmentioning
confidence: 99%
“…Data obtained from laboratory animals emphasized the pleiotropic nature of PCBs effects and the susceptibility of both developing and adult reproductive systems. In sheep exposed in utero , PCBs exerted subtle effects on fetal testis proteome but did not significantly disturb testis morphology and testosterone synthesis (Krogenæs et al 2014 ). Neonatal PCBs treatment increased testis weight and daily sperm production in adult rats, through induction of hypothyroidism, which led to an increase in Sertoli cell number (Cooke et al 1996 ).…”
Section: Introductionmentioning
confidence: 99%