In utero exposure to genistein decreased intranasal house dust mite-induced respiratory allergy in middle-aged male B6C3F1 offspring

Guo, Tai L.; Lefever, Daniel E.; Nagy, Tamás; Meng, Andrew

doi:10.1016/j.toxlet.2020.07.013

Cited by 3 publications

(4 citation statements)

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“…To understand whether intrauterine exposure to genistein modulates postnatal respiratory allergies in middle age, a study was conducted. The use of genistein in the intrauterine period (by gavage; 20 mg/kg body weight) had a protective effect on respiratory allergies in male offspring [147].…”

Section: Genistein and Pregnancymentioning

confidence: 97%

The Role of Genistein in Mammalian Reproduction

Guelfi,

Pasquariello,

Anipchenko

et al. 2023

Molecules

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Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. Genistein is considered a phytoestrogen. As such, genistein can bind estrogen receptors (ERα and ERβ), although with a lower affinity than that of estradiol. Despite considerable work, the effects of genistein are not well established yet. This review aims to clarify the role of genistein on female and male reproductive functions in mammals. In females, at a high dose, genistein diminishes the ovarian activity regulating several pathway molecules, such as topoisomerase isoform I and II, protein tyrosine kinases (v-src, Mek-4, ABL, PKC, Syk, EGFR, FGFR), ABC, CFTR, Glut1, Glut4, 5α-reductase, PPAR-γ, mitogen-activated protein kinase A, protein histidine kinase, and recently circulating RNA-miRNA. The effect of genistein on pregnancy is still controversial. In males, genistein exerts an estrogenic effect by inducing testosterone biosynthesis. The interaction of genistein with both natural and synthetic endocrine disruptors has a negative effect on testis function. The positive effect of genistein on sperm quality is still in debate. In conclusion, genistein has a potentially beneficial effect on the mechanisms regulating the reproduction of females and males. However, this is dependent on the dose, the species, the route, and the time of administration.

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Section: Genistein and Pregnancymentioning

confidence: 97%

The Role of Genistein in Mammalian Reproduction

Guelfi,

Pasquariello,

Anipchenko

et al. 2023

Molecules

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“…In 2006, a systematic review showed that the use of SF in infants had no apparent effect in the prevention of allergy or food intolerance 1 . However, more recent studies have demonstrated the role of soy isoflavones as immunomodulators in allergic disease development 2–6 . For example, in utero exposure to the soy isoflavone genistein may decrease house dust mite‐induced respiratory allergy as indicated by decreases in airway hyperresponsiveness, house dust mite‐specific IgG1 levels, and pulmonary eosinophil peroxidase activity in a murine model 2 .…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5][6] For example, in utero exposure to the soy isoflavone genistein may decrease house dust mite-induced respiratory allergy as indicated by decreases in airway hyperresponsiveness, house dust mite-specific IgG1 levels, and pulmonary eosinophil peroxidase activity in a murine model. 2 Cho et al 3 showed that soy isoflavone treatment in patients with asthma can reduce plasma plasminogen activator inhibitor-1 levels and the frequency of asthma exacerbations that require oral corticosteroids. Furthermore, Park et al 4 demonstrated that 7,3′,4′-trihydroxyisoflavone, which features an additional -OH group bonded to the soy isoflavone daidzein at the ortho position on the B ring, decreases the levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in human skin keratinocytes, and also alleviates symptoms of atopic dermatitis in a murine model.…”

Section: Introductionmentioning

confidence: 99%

“…1 However, more recent studies have demonstrated the role of soy isoflavones as immunomodulators in allergic disease development. [2][3][4][5][6] For example, in utero exposure to the soy isoflavone genistein may decrease house dust mite-induced respiratory allergy as indicated by decreases in airway hyperresponsiveness, house dust mite-specific IgG1 levels, and pulmonary eosinophil peroxidase activity in a murine model. 2 Cho et al 3 showed that soy isoflavone treatment in patients with asthma can reduce plasma plasminogen activator inhibitor-1 levels and the frequency of asthma exacerbations that require oral corticosteroids.…”

Section: Introductionmentioning

confidence: 99%

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Effects of regular soy formula intake between 1 and 2 months of age on food sensitization in infancy

Sakihara

Otsuji

Arakaki

et al. 2022

Pediatric Allergy Immunology

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Background The effects of regular soy formula (SF) intake on the development of food sensitization in infancy remain unclear. This study aimed to assess the effects of regular SF intake between 1 and 2 months of age on food sensitization development by 6 months of age. Methods Using data from a randomized controlled trial of a birth cohort from four Japanese hospitals that assessed cow's milk allergy development, we performed a retrospective cohort study of 235 infants who avoided cow's milk formula and supplemented breastfeeding with SF as required between 1 and 2 months of age. Regular SF intake was defined as SF consumption of ≥14 days per month and ≥1350 ml per month. Food sensitization was defined as positive skin prick test reactions to hen's egg, cow's milk, wheat, and/or soy. Using multivariable logistic regression models that adjusted for parental, perinatal, and environmental factors, we calculated the adjusted odds ratios of regular SF intake for food, hen's egg, and cow's milk sensitization by 6 months of age. Results From the 235 participants, 114 (48.5%) had regular SF intake. The adjusted odds ratios of regular SF intake for food, hen's egg, and cow's milk sensitization were 0.32 (95% confidence interval: 0.16–0.62, p = .0007), 0.42 (0.20–0.88, p = .02), and 0.33 (0.14–0.81, p = .02), respectively. Conclusion Regular SF intake between 1 and 2 months of age in infants avoiding cow's milk formula was significantly associated with a reduced risk of food sensitization in infancy.

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