In Utero Polychlorinated Biphenyl Exposures in Relation to Fetal and Early Childhood Growth

Hertz‐Picciotto, Irva; Charles, M. Judith; James, Rebecca; Keller, Jean; Willman, Eric J.; Teplin, Stuart W.

doi:10.1097/01.ede.0000173043.85834.f3

Cited by 142 publications

(127 citation statements)

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“…Hertz-Picciotto and colleagues [13] showed that in humans, in utero PCB exposure of males was associated with low birth weight and body weight for gestational age in boys, while in girls, in utero exposure was associated with shorter gestation. Within the same study, at five years of age, prenatal PCB exposure was associated with increased growth in girls but not boys [13].…”

Section: Discussionmentioning

confidence: 99%

“…The developmental origins of health and disease hypothesis, derived from the thrifty phenotype hypothesis put forth by Barker and Hales in 1992 [5], postulates that low birth weight offspring can result from insufficient nutrition in the intrauterine environment, leading to metabolic and other health derangements later in life [5][6][7][8][9][10]. In fact, maternal serum PCB levels in humans negatively correlate with infant birth weight and gestational age [11][12][13][14][15][16][17]. A meta-analysis comparing prenatal PCB exposure and birth weight effects across 12 European birth cohorts found a significant negative correlation between cord blood PCB levels and birth weight [11].…”

Section: Introductionmentioning

confidence: 99%

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Perinatal polychlorinated biphenyl 126 exposure alters offspring body composition

2016

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Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose exposure levels are associated with various health hazards. We hypothesized that in utero and lactational exposure to PCBs can cause changes in body composition and obesity in a mouse model. Pregnant mice were exposed biweekly to two concentrations of PCB 126 via oral gavage. Maternal PCB exposure did not result in heavier offspring, however, dose-dependent and sex specific changes in body composition were observed. Female offspring displayed the most susceptibility to PCBinduced alterations in body composition, having less percent lean body mass and increased adiposity compared to females born to control dams, and these effects were largely dosedependent. In contrast to females, and independent of the exposure level of PCB 126, male offspring had reduced lean body mass but no change in fat mass compared to males born to control dams. In conclusion, perinatal PCB 126 exposure did not affect body weight, but rather modulated body composition in a dose-dependent and gender-specific manner.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Perinatal polychlorinated biphenyl 126 exposure alters offspring body composition

2016

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“…There were few results reported gender difference, they frequently indicated a stronger negative effect on the birth weight among male infants (Rylander et al, 1996;Baibergenova et al, 2003;Sonneborn et al, 2008;Hertz-Picciotto et al, 2005;Vartiainen et al, 1998). Previous reports have indicated that increased maternal serum PCBs levels are associated with reduced birth weight in male infants and have suggested a greater susceptibility of male conceptuses, either in the fetal or embryonic period (Sonneborn et al, 2008;Hertz-Picciotto et al, 2005). Some of the studies reporting gender difference in the PCBs effects did not actually measure PCBs levels, but used a surrogate for exposure such as estimated fish consumption (Rylander et al, 1996) or residential information (Baibergenova et al, 2003), which may entail greater errors in exposure classification.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies of lower-level PCBs exposure during pregnancy observed associations with decreased birth weight and other growth parameters (Fein et al, 1984;Rylander et al, 1996: Rylander et al, 1998Patandin et al, 1998;Karmaus and Zhu, 2004;Hertz-Picciotto et al, 2005;Sagiv et al, 2007;Sonneborn et al, 2008). In the Lake Michigan fish consumer study, cord serum PCBs levels predicted LBW and smaller birth head circumference (Fein et al, 1984).…”

Section: Introductionmentioning

confidence: 98%

“…Thus, reported results on the relationship between birth weight and the levels of PCDDs/PCDFs and DL-PCBs are currently limited and inconsistent. Furthermore, some studies have reported a difference between genders with regard to the effects of PCBs and PCDDs/PCDFs on birth outcomes (Rylander et al, 1996;Baibergenova et al, 2003;Sonneborn et al, 2008;Hertz-Picciotto et al, 2005;Vartiainen et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Konishi

Sasaki

Kato

et al. 2009

Environmental Research

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Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes.However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies.A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood.Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted β = -231.5 g, 95% CI: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted β = -258.8 g, 95% CI: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted β = -24.5 g, 95% CI: -387.4 to -61.5).Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight.

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Environmental Agents and Reproductive Risk

Goetzl¹

2007

Management of High‐Risk Pregnancy

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In Utero Polychlorinated Biphenyl Exposures in Relation to Fetal and Early Childhood Growth

Abstract: Maternally mediated exposure to PCBs may be detrimental to fetal growth, particularly in boys. These effects apparently are not persistent. Interpretation of greater childhood growth of girls is unclear.

Cited by 142 publications

References 45 publications

Perinatal polychlorinated biphenyl 126 exposure alters offspring body composition

Perinatal polychlorinated biphenyl 126 exposure alters offspring body composition

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Environmental Agents and Reproductive Risk

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