Many fields including the aerospace industry have shown increased interest in the use of plastics to lower the mass of systems. However, the use of plastics in space can be challenging for a number of reasons. Ultraviolet radiation, atomic oxygen and other phenomena specifically associated with space cause the degradation of polymers. Here we show a path towards creation of space-grade components by combining additive manufacturing (AM) and atomic layer deposition (ALD). Our method produced ALD Al2O3 coated thermoplastic parts, suitable for space applications. The highlight of this work is a significant reduction in outgassing, demonstrated using residual gas analyzer (RGA) sampling. Compared to uncoated parts, the ALD-Al2O3 coating decreased the outgassing of polyether ether ketone (PEEK), acrylonitrile butadiene styrene (ABS), polycarbonate (PC) and nanodiamond-doped polylactide (ND-PLA) by 46%, 49%, 58% and 65% respectively.The manufacturing method used in this work enables the use of topology optimization already in the early concept creation phase. The method is ideally suited for spacecraft applications, where the volume and mass of parts is critical, and could also be adapted for in-space manufacturing.