In vitro Action of Aureomycin on Oxidative Phosphorylation in Animal Tissues

Some metabolic aspects of tetracyclines

“…Others have confirmed this action of CTC but noted that, at higher concentration, this antibiotic inhibited both phosphorylation and respiration in rat whole liver homogenates 74 and mitochondria. 75 CTC, OTe, and TC had similar depressant actions on oxidative phosphorylation and fatty acid metabolism by rat mitochondria provided the Mg++ concentration was sufficiently 10w. 12 Mg++ was capable of reversing the inhibition.…”

MAGNAMYCIN.1 II. MYCAROSE, AN UNUSUAL BRANCHED-CHAIN DESOXYSUGAR FROM MAGNAMYCIN

“…The extracts were dialyzed with stirring for 96 hours ai 5' versus 4 liters of frequently changed distilled water. Arylamine formation was determined by the Bratton-Marshall technique.…”

“…Scand., 4 It would appear that the different ferri hemoprotein/ferro hemoprotein systems range from among the most positive biological oxidationreduction systems known to among the most negative systems known, It seems reasonable to ask now whether the well-known resistance to reduction displayed by free catalase might not be at least in part the result of a very negative oxidation-reduction potential for the ferri catalase/ ferro catalase system. Scand., 4 It would appear that the different ferri hemoprotein/ferro hemoprotein systems range from among the most positive biological oxidationreduction systems known to among the most negative systems known, It seems reasonable to ask now whether the well-known resistance to reduction displayed by free catalase might not be at least in part the result of a very negative oxidation-reduction potential for the ferri catalase/ ferro catalase system.…”

Divalent Cation Reversal of Tetracycline-Inhibited Respiration of Klebsiella pneumoniae

“…(2) reported the inhibition of oxidation by chlortetracycline in rat liver mitochondria and found that inhibition occurred in the presence of magnesium ion, low phosphate concentrations, and adenosine triphosphate. The introduction of added magnesium reversed this inhibition.…”

“…The mutual effects of tetracycline and metallic cations for various biological systems have been reported (2,3). An interest in the carbohydrate and protein metabolism of Klebsiella pneumoniae led to an investigation of the ability of certain divalent cations to reverse tetracycline-inhibited respiration in this microorganism.…”