In vitro activities of T-3262, NY-198, fleroxacin (AM-833; RO 23-6240), and other new quinolone agents against clinically isolated Chlamydia trachomatis strains

Abstract

The in vitro activities of three newly developed quinolone drugs and fleroxacin ) against 10 strains of clinically isolated Chiamydia trachomatis were assessed and compared with those of other quinolones and minocycline. T-3262 (MIC for 90% of isolates tested, 0.1 ,ug/ml) was the most active of the quinolones. The NY-198 and fleroxacin MICs for 90% of isolates were 3.13 and 62.5 ,ug/ml, respectively.

In vitro activity of tosufloxacin (A-61827; T-3262) against selected genital pathogens

“…Our results indicate that tosufloxacin is as active against C. trachomatis from our geographic area as it is against C. trachomatis from Japan. The MICs and MBCs of temafloxacin and ciprofloxacin that we report are comparable to those obtained by other investigators (7)(8)(9). There is no published information on the activity of tosufloxacin against SRNG.…”

“…DISCUSSION The in vitro activity of tosufloxacin against C. trachomatis was recently reported by Maeda et al (7). Our results indicate that tosufloxacin is as active against C. trachomatis from our geographic area as it is against C. trachomatis from Japan.…”

“…Since concentrations of tosufloxacin in serum vary from 0.4 to 0.8 gxg/ml when a dose of 150 mg twice daily is administered, sufficient distribution of the drug to eradicate C. trachomatis would be expected and clinical trials are warranted (7). The excellent in vitro activity of tosufloxacin against N. gonorrhoeae, including SRNG and PPNG strains, indicates that this drug may be as active as other quinolones in the treatment of genital gonococcal infections.…”

In vitro and in vivo activities of sparfloxacin, other quinolones, and tetracyclines against Chlamydia trachomatis

“…Tetracyclines have been used frequently for chlamydial infections for many years, although they have some undesirable side effects. Recently, some new quinolones have been reported to have antichlamydial activity in vitro (1,7,9,16), and some of them have successfully been applied to chlamydial infections in humans (2,3). Sparfloxacin has been reported to have potent antichlamydial activity (10), but its position in antichlamydial chemotherapy remains uncertain because of the relatively few comparative data available.…”

Laboratory Survey of Fluoroquinolone Activity

“…Against Chlamydia trachomatis, ciprofloxacin [76][77][78][79][80], ofloxacin [77,78], fleroxacin [78], lomefloxacin [78], and other investigational quinolones [78,80] have shown inhibitory activity at concentrations attainable in serum. The standard drugs tetracycline and erythromycin, however, are more active on a weight-for-weight basis, and the actual role of quinolones in therapy for chlamydial infections has yet to be determined.…”