In Vitro Activity of a New Oral Triazole, BMS-207147 (ER-30346)

Fung‐Tomc, Joan; Huczko, E; Minassian, Beatrice; Bonner, Daniel P.

doi:10.1128/aac.42.4.993

Cited by 83 publications

(53 citation statements)

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“…Our results are not in complete agreement with those reported in other studies that have used the macrodilution method (Fung-Tomc et al 1998;Perea et al 2001), probably because of differences in the culture medium. Perea et al (2001), using RPMI 1640 medium, obtained MIC 50 and MIC 90 values for fluconazole of 16 µg·mL -1 and 64 µg·mL -1 , respectively, whereas we obtained MIC 50 = 64 µg·mL -1 and MIC 90 >64 µg·mL -1 .…”

Section: Discussioncontrasting

confidence: 68%

Determination of susceptibility/resistance to antifungal drugs ofTrichophyton mentagrophytesisolates by a macrodilution method

Barros¹,

Hamdan²

2005

Can. J. Microbiol.

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Onychomycosis is a common adult human mycosis, and dermatophytes of the Trichophyton genera are the most frequently isolated microorganism. Globally, from 3% to 10% of the human population is attacked by ony cho mycosis, and many cases involve toenails. The aim of this work was to determine the minimal inhibitory concentrations (MICs) of antifungal drugs (fluconazole, ketoconazole, itraconazole, terbinafine, and griseofulvin) often used for the treatment of ungueal dermatophytosis caused by Trichophyton mentagrophytes. The MICs were determined by the broth medium macrodilution method. The results showed that activities of terbinafine and itraconazole were significantly higher (MIC <0.007-0.015 microg.mL -1 and MIC = 0.062-1.000 microg.mL -1, respectively). All isolates had reduced susceptibility to fluconazole (MIC = 16 to >64 microg.mL -1). The MICs of ketoconazole and griseofulvin varied among strains, ranging from 0.125 to 2.000 microg.mL -1 for ketoconazole and from 0.25 to 2.00 microg.mL -1 for griseofulvin. These MICs were higher than those of other studies cited, possibly because of differences in culture medium used in the other studies.

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Section: Discussioncontrasting

confidence: 68%

Determination of susceptibility/resistance to antifungal drugs ofTrichophyton mentagrophytesisolates by a macrodilution method

Barros¹,

Hamdan²

2005

Can. J. Microbiol.

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“…One in vitro study of 16 Aspergillus isolates demonstrated comparable fungicidal activity and MICs of ravuconazole, itraconazole, and amphotericin B [231]. In vitro comparisons against the 2 other new triazoles and amphotericin B and itraconazole demonstrated similar MICs among the 4 azole compounds and general superiority over amphotericin B against various Aspergillus species [232].…”

Section: Ravuconazole (Bms-207147 Er-30346)mentioning

confidence: 95%

Review of Newer Antifungal and Immunomodulatory Strategies for Invasive Aspergillosis

2003

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The incidence of invasive aspergillosis is markedly increasing, and mortality remains dismal. Previously there were only 2 antifungals with activity against Aspergillus, but over the last few years there has been an explosion of newer agents and reformulations of older antifungals. Exploration has also begun with immunotherapy, with use of cytokines and granulocyte transfusions alone or in combination with antifungal therapy. This review will detail the available in vitro, in vivo, and clinical experience with the newer antifungal and immunomodulatory therapies in development for treatment of invasive aspergillosis.

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“…Promising in vitro data have been presented for the new triazoles [39,60]. Nevertheless, correlation to clinical outcomes has not been established for Paecilomyces spp.. and therapy must be adjusted to clinical response.…”

Section: Acremonium Speciesmentioning

confidence: 97%

“…Triazoles or the echinocandins are inactive as single agents [39,42,46,60,74,140]. Because there are currently no alternatives to amphotericin B, an accurate histological or microbiological diagnosis is essential.…”

Section: Zygomycetesmentioning

confidence: 99%

Uncommon opportunistic fungi: new nosocomial threats

Groll

Walsh

2001

Clinical Microbiology and Infection

274

175

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During the past two decades opportunistic fungal infections have emerged as important causes of morbidity and mortality in patients with severe underlying illnesses and compromised host defenses. While Aspergillus and Candida spp. collectively account for the majority of these infections, recent epidemiological trends indicate a shift towards infections by Aspergillus spp., nonalbicans Candida spp., as well as previously uncommon opportunistic fungi. Apart from an expanding number of different Zygomycetes, previously uncommon hyaline filamentous fungi (such as Fusarium species, Acremonium species, Paecilomyces species, Pseudallescheria boydii, and Scedosporium prolificans), dematiaceous filamentous fungi (such as Bipolaris species, Cladophialophora bantiana, Dactylaria gallopava, Exophiala species, and Alternaria species) and yeast-like pathogens (such as Trichosporon species, Blastoschizomyces capitatus, Malassezia species, Rhodotorula rubra and others) are increasingly encountered as causing life threatening invasive infections that are often refractory to conventional therapies. On the basis of past and current trends, the spectrum of fungal pathogens will continue to evolve in the settings of an expanding population of immunocompromised hosts, selective antifungal pressures, and shifting conditions in hospitals and the environment. An expanded and refined drug arsenal, further elucidation of pathogenesis and resistance mechanisms, establishment of in vitro/in vivo correlations, incorporation of pharmacodynamics, combination- and immunotherapies offer hope for substantial progress in prevention and treatment.

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In Vitro Activity of a New Oral Triazole, BMS-207147 (ER-30346)

Cited by 83 publications

References 0 publications

Determination of susceptibility/resistance to antifungal drugs ofTrichophyton mentagrophytesisolates by a macrodilution method

Determination of susceptibility/resistance to antifungal drugs ofTrichophyton mentagrophytesisolates by a macrodilution method

Review of Newer Antifungal and Immunomodulatory Strategies for Invasive Aspergillosis

Uncommon opportunistic fungi: new nosocomial threats

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