In vitro activity of ceftolozane/tazobactam against clinical isolates of Pseudomonas aeruginosa in the planktonic and biofilm states

Perez, Antonio L. Velez; Schmidt-Malan, Suzannah M.; Kohner, Peggy C.; Karau, Melissa J.; Greenwood‐Quaintance, Kerryl E.; Patel, Robin

doi:10.1016/j.diagmicrobio.2016.02.014

Cited by 20 publications

(11 citation statements)

References 12 publications

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“…Biofilms, which can be described as surface-attached layers of microbial cells with self-produced extracellular polymeric compounds, are a critical source of morbidity and mortality in medical practice. Biofilms may develop on human tissues as well as on a diversity of surfaces, such as prosthetic devices, venous catheters, and cardiac pacemakers; their management can be complicated and costly because they are often intrinsically resistant to high levels of antimicrobial drugs [ 2 ]. Pseudomonas aeruginosa is accepted as a model biofilm-forming pathogenic microorganism and is considered to be the most threatening pathogen causing biofilm in a human host [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

In vitro synergy of antibiotic combinations against planktonic and biofilm Pseudomonas aeruginosa

Ghorbani

Memar

Sefidan

et al. 2017

GMS Hygiene and Infection Control; 12:Doc17

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Section: Introductionmentioning

confidence: 99%

In vitro synergy of antibiotic combinations against planktonic and biofilm Pseudomonas aeruginosa

Ghorbani

Memar

Sefidan

et al. 2017

GMS Hygiene and Infection Control; 12:Doc17

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“…and ESBLs Enterobacteriaceae (42,43). As evidence of it, Farrell et al have reported that C/T is the most active agent against PA (44) confirmed in several studies against strains grown in biofilms (45,46).…”

Section: Antimicrobial Properties Of C/tmentioning

confidence: 87%

New cephalosporins for the treatment of pneumonia in internal medicine wards

et al. 2020

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The burden of hospital admission for pneumonia in internal medicine wards may not be underestimated; otherwise, cases of pneumonia are a frequent indication for antimicrobial prescriptions. Community-and hospital-acquired pneumonia are characterized by high healthcare costs, morbidity and non-negligible rates of fatality. The overcoming prevalence of resistant gram-negative and positive bacteria (e.g., methicillin-resistant Staphylococcus aureus, penicillin and ceftriaxone-resistant Streptococcus pneumoniae, extended-spectrum β-lactamases and carbapenemases producing Enterobacteriaceae) has made the most of the first-line agents ineffective for treating lower respiratory tract infections. A broad-spectrum of activity, favourable pulmonary penetration, harmlessness and avoiding in some cases a combination therapy, characterise new cephalosporins such as ceftolozane/tazobactam, ceftobiprole, ceftazidime/avibactam and ceftaroline. We aimed to summarise the role and place in therapy of new cephalosporins in communityand hospital-acquired pneumonia within the setting of internal medicine wards. The "universal pneumonia antibiotic strategy" is no longer acceptable for treating lung infections. Antimicrobial therapy should be individualized considering local antimicrobial resistance and epidemiology, the stage of the illness and potential host factors predisposing to a high risk for specific pathogens.

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“…Although biofilms exert a positive role in a variety of ecosystems they are often associated to the survival of pathogens during antibiotic treatment leading to worse clinical outcomes [ 89 ]. Indeed, it is known that P. aeruginosa strain biofilm producers show a greater resistance to common antibiotic treatment [ 90 , 91 , 92 ] and they are often associated to medical device colonization and nosocomial infections [ 93 ]. Many bacteria, including Pseudomonas strains are equipped with a quorum sensing (QS) system able to control biofilm production and the release of different virulence factor in response to environmental stimuli.…”

Section: Isothiocyanates Antimicrobial Properties Against Human Pamentioning

confidence: 99%

“…Over the years, multi-resistant strains of P. aeruginosa biofilm producers have been isolated from patients. The acquisition of new resistance phenotypes underlines the need for new antibiotic therapeutic strategies and anti-biofilm molecular compounds [ 90 , 92 , 93 , 98 , 99 ].…”

Section: Isothiocyanates Antimicrobial Properties Against Human Pamentioning

confidence: 99%

Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections

et al. 2018

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The use of plant-derived products as antimicrobial agents has been investigated in depth. Isothiocyanates (ITCs) are bioactive products resulting from enzymatic hydrolysis of glucosinolates (GLs), the most abundant secondary metabolites in the botanical order Brassicales. Although the antimicrobial activity of ITCs against foodborne and plant pathogens has been well documented, little is known about their antimicrobial properties against human pathogens. This review collects studies that focus on this topic. Particular focus will be put on ITCs’ antimicrobial properties and their mechanism of action against human pathogens for which the current therapeutic solutions are deficient and therefore of prime importance for public health. Our purpose was the evaluation of the potential use of ITCs to replace or support the common antibiotics. Even though ITCs appear to be effective against the most important human pathogens, including bacteria with resistant phenotypes, the majority of the studies did not show comparable results and thus it is very difficult to compare the antimicrobial activity of the different ITCs. For this reason, a standard method should be used and further studies are needed.

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In vitro activity of ceftolozane/tazobactam against clinical isolates of Pseudomonas aeruginosa in the planktonic and biofilm states

Cited by 20 publications

References 12 publications

In vitro synergy of antibiotic combinations against planktonic and biofilm Pseudomonas aeruginosa

In vitro synergy of antibiotic combinations against planktonic and biofilm Pseudomonas aeruginosa

New cephalosporins for the treatment of pneumonia in internal medicine wards

Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections

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