In Vitro Activity of Fluoroquinolones, Azithromycin and Doxycycline against Chlamydia Trachomatis Cultured from Men with Chronic Lower Urinary Tract Symptoms

Urethritis and antimicrobial resistance

“…In one in vitro experiment, doxycycline showed the least activity against C. trachomatis compared with azithromycin or fluoroquinolones. Ofloxacin activity was found to be almost similar to azithromycin (54). Thus, therapy of C. trachomatis is initiated empirically.…”

Chlamydia trachomatis infection: a challenge for the urologist

“…20 The authors, however, concluded that the conditions of in vitro susceptibility studies are incompatible with the infection as it occurs in vivo even if could be useful to include investigations for antibiotic susceptibility in every patient prior to treatment. 20 In a recent study Cai et al, by means of a prospective, randomized and open-label study on 221 patients affected by chronic prostatitis due to Ct infection who had undergone oral administered prulifloxacin 600 mg once daily for 14 days or doxycycline 100 mg orally twice daily for 21 days, found that prulifloxacin was equivalent to the standard therapy. 21 In this study, moreover, the Authors showed that prulifloxacin was superior over standard therapy in microbiological efficacy rates in terms of mucosal IgA and IL-8 levels decreasing.…”

“…20 Moreover, the same Authors stated that the decision on the prescription of pefloxacin or lomefloxacin should be made individually, but ciprofloxacin treatment is not suggested. 20 The authors, however, concluded that the conditions of in vitro susceptibility studies are incompatible with the infection as it occurs in vivo even if could be useful to include investigations for antibiotic susceptibility in every patient prior to treatment. 20 In a recent study Cai et al, by means of a prospective, randomized and open-label study on 221 patients affected by chronic prostatitis due to Ct infection who had undergone oral administered prulifloxacin 600 mg once daily for 14 days or doxycycline 100 mg orally twice daily for 21 days, found that prulifloxacin was equivalent to the standard therapy.…”

“…2 Moreover, although little is known about Ct survival in the presence of fluoroquinolones, it is well known that after multiple cultivation passages resistant mutant for some fluoroquinolones were determined. 20 In a recent report, Smelov and co-workers suggested that ofloxacin could be recommended as the primary drug in the treatment of chlamydia-infected patients with CP, due to its pharmacokinetic parameters. 20 Moreover, the same Authors stated that the decision on the prescription of pefloxacin or lomefloxacin should be made individually, but ciprofloxacin treatment is not suggested.…”

“…20 In a recent report, Smelov and co-workers suggested that ofloxacin could be recommended as the primary drug in the treatment of chlamydia-infected patients with CP, due to its pharmacokinetic parameters. 20 Moreover, the same Authors stated that the decision on the prescription of pefloxacin or lomefloxacin should be made individually, but ciprofloxacin treatment is not suggested. 20 The authors, however, concluded that the conditions of in vitro susceptibility studies are incompatible with the infection as it occurs in vivo even if could be useful to include investigations for antibiotic susceptibility in every patient prior to treatment.…”