In vitro activity of fosfomycin against Haemophilus influenzae, Streptococcus pneumoniae and Neisseria species

Fosfomycin: Interpretation of Inhibition Zones Obtained with the Bauer-Kirby Agar Disk Diffusion Susceptibility Test

“…Taken together, our results confirm previously published data regarding the antibacterial spectrum of fosfomycin [1,3,5,10]. It should be stressed that the majori ty of our S. aureus isolates were either re sistant against penicillins, including methicillin, or producers of //-lactamases; thus, fosfomycin appears to present a useful al ternative for antistaphylococcal chemo therapy.…”

“…1). All H. influenzae isolates proved susceptible in terms of MICs [1], but the relevant inhibition zone diameters varied tremendously; therefore, caution should be exercised in the interpretation of inhibition zones obtained on chocolatized MHA. For Enterobacteriaceae and P. aeruginosa we propose the following in hibition zone criteria: ¿ 10 mm = R; 11-15 = I; and ^ 16 mm = S. Caution is called for the interpretation of inhibition zones yielded by isolates comprising the Klebsiella-Enterobacier-Serralia group; for these bacteria, the clinical microbiology laboratory might have to determine agar dilution MICsoffosfomycin.…”

“…Fosfomycin, an inhibitor of bacterial cell wall synthesis, was demonstrated by various investigators to display potent ac tivity against diverse gram-positive and gram-negative bacteria [1,3,5,10], The present study was undertaken with the aim of providing those clinical microbiology laboratories, which utilize the Bauer-Kir by method [2] of antibiotic susceptibility testing, with interpretative inhibition zone criteria, since these had not been pub lished previously.…”

Plasmid-encoded fosfomycin resistance

“…It aroused considerable interest, since it was a completely new molecule having antibacterial activity which exhibited relevant properties, such as a broad spectrum, covering many pathogenic and opportunistic gram-positive (Staphylococcus aureus and Streptococcus spp.) and gram-negative (Pseudomonas aeruginosa, Neisseria spp., and members of the family Enterobacteriaceae) bacteria (5,19,35,43,68). Furthermore, in combination with other antimicrobial agents, it was synergistic (17,24,50,51,61).…”

Activity of Fosfomycin and R-Plasmid Conferring Fosfomycin Resistance among Some Clinical Bacteria Isolates in Nigeria

“…Fosfomycin has been reported to have a broad-spectrum activity against gram-ne gative and gram-positive bacteria [1,4,11,18,26]. It inhibits bacterial cell wall syn thesis by inactivating enoylpyruvyl trans ferase that catalyzes the formation of UDP-N-acetylmuramic acid [16].…”