In vitro activity of nadifloxacin against several Gram-positive bacteria and analysis of the possible evolution of resistance after 2 years of use in Germany

Alba, Verónica; Urbán, Edit; Domı́nguez, M.A.; Nagy, Elisabeth; Nord, Carl‐Erik; Palacín, Creu; Vila, Jordi

doi:10.1016/j.ijantimicag.2008.08.024

Cited by 24 publications

(32 citation statements)

References 14 publications

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“…Propionibacterium acnes and Staphylococcus aureus are pathogens of skin infections, such as acne vulgaris and impetigo, respectively [1,2]. Topical nadifloxacin and clindamycin are frequently used for the treatment of acne vulgaris and impetigo in Japan [3,4], while topical gentamicin and fusidic acid are used for the treatment of a wide range of skin infections [5]. Recently, clindamycin-resistant P. acnes, which contribute to refractory skin infections, have been frequently isolated in the USA, Europe, and Japan [2,6].…”

Section: Introductionmentioning

confidence: 99%

Determination of the Mutant Prevention Concentration and the Mutant Selection Window of Topical Antimicrobial Agents against Propionibacterium acnes

et al. 2016

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Determination of the mutant prevention concentration (MPC) and the mutant selection window (MSW) of antimicrobial agents used to treat pathogenic bacteria is important in order to apply effective antimicrobial therapies. Here, we determined the MPCs of the major topical antimicrobial agents against Propionibacterium acnes and Staphylococcus aureus which cause skin infections and compared their MSWs. Among the MPCs of nadifloxacin and clindamycin, the clindamycin MPC was determined to be the lowest against P. acnes. In contrast, the nadifloxacin MPC was the lowest against S. aureus. Calculations based on the minimum inhibitory concentrations and MPCs showed that clindamycin has the lowest MSW against both P. acnes and S. aureus. Nadifloxacin MSWs were 4-fold higher against P. acnes than against S. aureus. It is more likely for P. acnes to acquire resistance to fluoroquinolones than S. aureus. Therefore, topical application of clindamycin contributes very little to the emergence of resistant P. acnes and S. aureus strains.

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Section: Introductionmentioning

confidence: 99%

Determination of the Mutant Prevention Concentration and the Mutant Selection Window of Topical Antimicrobial Agents against Propionibacterium acnes

et al. 2016

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“…16 However, the ratios of nadifloxacin resistances were found to be similar in Germany where topical nadifloxacin have been used for a few years and in Spain where topical nadifloxacin has not been prescribed too often. 17 A clinical study of Ueno et al, reported no nadifloxacin resistant P. acnes species. 18 On the contrary, some antibiotics such as erythromycin and clindamycin; mostly used in AV management frequently cause P. acnes resistance.…”

Section: Discussionmentioning

confidence: 98%

Clinical and Bacteriological Evaluation of Nadifloxacin 1% Cream Versus Erythromycin 4% Gel in the Treatment of Mild-to-Moderate Facial Acne Vulgaris: A Randomized Study

Üstüner¹,

Güleç²,

Demirbilek³

2015

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : High percentage of Propionibacterium acnes resistance against erythromycin has been reported in recent years. Therefore, new antibiotic alternatives are being developed. Nadifloxacin is an effective treatment in mild-moderate acne vulgaris with antimicrobial, immunomodulatory and antiinflammatory properties. Comparison of the clinical and bacteriological efficacy and safety of nadifloxacin 1% cream versus erythromycin 4% gel in the treatment of mild to moderate acne vulgaris was aimed. M Ma a--t te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 100 patients with facial mild-moderate acne vulgaris were randomized to receive nadifloxacin 1% cream (Group I) or erythromycin 4% gel (Group II) twice daily for 12 weeks. All the patients in both groups also used topical 0.05% tretinoin twice a week at night time for 12 weeks. Both groups were compared regarding the lesion counts and global acne grading score. The growth ratios of P. acnes and S. epidermidis were evaluated. The bacterial antibiotic resistance was assessed by using the minimum inhibitory concentration values of nadifloxacin and erythromycin. R Re es su ul lt ts s: : After a 12-week treatment period, both treatments caused significant similar reductions in all types of acne lesions and the global acne grading scores. Microbiological evaluation revealed no significant differences regarding the growth ratios of P. acnes and S. epidermidis in both groups. The nadifloxacin resistant S. epidermidis colonization was significantly higher in Group I at week 12. C Co on nc cl lu us si io on n: : Nadifloxacin 1% cream is as efficacious and safe as erythromycin 4% gel in the treatment of mild to moderate acne vulgaris. K Ke ey y W Wo or rd ds s: : Acne vulgaris; drug resistance, bacterial; erythromycin; microbial sensitivity tests; nadifloxacin; Propionibacterium acnes; Staphylococcus epidermidis Ö ÖZ ZE ET T A Am ma aç ç: : Son yıllarda eritromisine karşı yüksek oranda Propionibacterium acnes direnci bildirilmiş-tir. Bu nedenle yeni topikal antibiyotik alternatifleri geliştirilmektedir. Nadifloksasin, hafif orta şiddetli akne vulgariste antimikrobiyal, immünmodülatüar ve antiinflamatuar özellikleri ile etkin bir tedavidir. Bu çalışmada, hafif-orta şiddetli akne vulgaris tedavisinde %1 nadifloksasin krem ile %4 eritromisin jelin klinik ve bakteriyolojik olarak etkinlik ve güvenirliklerinin karşılaştırılması amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön n--t te em ml le er r: : Hafif-orta şiddetli akne vulgarisli toplam 100 hasta, 12 hafta boyunca, günde iki kez %1 nadifloksasin krem (Grup I) veya %4 eritromisin jel (Grup II) kullanmak üzere iki gruba randomize edildi. Her iki gruptaki tüm hastalar ayrıca, 12 hafta boyunca geceleri haftada iki gün topikal %0,05 tretinoin kullandı. Her iki grup lezyon sayısı ve global akne şiddet skoru göz önüne alınarak karşılaştırıldı. P. acnes ve Staphylococcus epidermidis'in üreme oranları değerlendirildi. Ayrıca, nadifloksasin ve eritromisinin minimum inhibitör ...

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“…Alba ve ark. 25 , Almanya'da birkaç Gram-pozitif bakteriye karşı nadifloksasin direnç gelişimini incelemek için bir çalışma yapmışlardır. Sonuçlar, bu antibiyotiğin Almanya'da 3 yıldır kullanılmasına rağmen nadifloksasine karşı direnç oranında yükselme olmadığını ve dirençli bir suş oluşmadığını, fakat eritromisin ve klindamisin için direnç oranlarının sırasıyla %28 ve %10 olduğunu göstermiştir.…”

Section: Discussionunclassified

Resistance status of antibiotics in Gram-positive bacteria isolated from acne lesions in İstanbul

Doğan¹,

Bektöre²,

Karabacak³

et al. 2017

TURKDERM

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Background and Design: Acne vulgaris is a multifactorial disease in which Propionibacterium acnes is thought to play an important role in the pathogenesis of inflamed lesions. There is also significant in vitro evidence suggesting a possible pathogenetic role for Staphylococci in acne vulgaris and an in vitro study of patients who were undergoing evaluation for acne, showed that 53% of participants were colonised with Staphylococcus epidermidis. Materials and Methods: In this study, 29 P. acnes isolates and 61 coagulase-negative staphylococci (CNS) isolates were obtained from 169 specimens belonging to patients with inflammatory acne vulgaris and the antimicrobial susceptibilities of these isolates against nadifloxacin, erythromycin, clindamycin and tetracycline were determined at the minimum inhibitory concentration levels, using the 'Clinical and Laboratory Standards Institute' agar dilution method. Results: There were no P. acnes isolate resistant to the antibiotics tested in this study and the antibiotic resistance status among CNS was as 28%, 36%, 23% and 0% for tetracycline, erythromycin, clindamycine and nadifloxacin, respectively. Conclusion: According to the results of this study, it may be expected that nadifloxacin could be more effective in the treatment of acne than other antimicrobial agents because of having no resistance to both P. acnes and CNS. However, this must be supported by clinical trials. Although resistance rates were found to be relatively low in this study, the antibiotic resistance problem should be taken into consideration while planning a treatment to get successful results. In case of treatment failures, presence of drug resistant strains should be considered. Keywords: Antibiotic resistance, topical, acne, İstanbul Amaç: Akne vulgaris, inflame lezyonların patogenezinde Propionibacterium acnes'in önemli bir rol oynadığı düşünülen multifaktöriyel bir hastalıktır. Ayrıca stafilokokların da akne vulgariste olası patogenetik rolü olduğuna dair önemli in vitro bulgular vardır. Yapılan bir çalışmada, akne açısından değerlendirilen katılımcıların %53'ünün Staphylococcus epidermidis ile kolonize olduğu gösterilmiştir. Gereç ve Yöntem: Bu çalışmada enflamatuvar akneli hastalardan sağlanan 169 örnekten, 29 P. acnes ve 61 koagülaz negatif stafilokok (KNS) izolatı elde edilmiş ve bu izolatların nadifloksasin, eritromisin, klindamisin ve tetrasikline karşı antimikrobiyal duyarlılıkları Klinik ve Laboratuvar Standartları Kurumu 'Clinical and Laboratory Standards Institute' agar dilüsyon metodu kullanılarak minimum inhibisyon konsantrasyonu seviyesinde belirlenmiştir. Bulgular: Hiçbir P. acnes izolatı bu çalışmada kullanılan antibiyotiklere dirençli değildi. KNS izolatlardaki direnç durumu ise tetrasiklin, eritromisin, klindamisin ve nadifloksasine karşı sırasıyla %28, %36, %23 ve %0 olarak saptandı. Sonuç: Bu çalışma verilerine göre, nadifloksasine karşı P. acnes ve KNS izolatlarında herhangi bir direnç saptanmaması nedeniyle, nadifloksasinin akne tedavisinde daha etkili olabileceği düşünülebil...

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In vitro activity of nadifloxacin against several Gram-positive bacteria and analysis of the possible evolution of resistance after 2 years of use in Germany

Cited by 24 publications

References 14 publications

Determination of the Mutant Prevention Concentration and the Mutant Selection Window of Topical Antimicrobial Agents against <b><i>Propionibacterium acnes</i></b>

Determination of the Mutant Prevention Concentration and the Mutant Selection Window of Topical Antimicrobial Agents against <b><i>Propionibacterium acnes</i></b>

Clinical and Bacteriological Evaluation of Nadifloxacin 1% Cream Versus Erythromycin 4% Gel in the Treatment of Mild-to-Moderate Facial Acne Vulgaris: A Randomized Study

Resistance status of antibiotics in Gram-positive bacteria isolated from acne lesions in İstanbul

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