In vitro activity of newer antibiotics against Corynebacterium jeikeium, Corynebacterium amycolatum and Corynebacterium urealyticum

Hernández, J. Sánchez; Peris, Begoña Mora; Guirao, Genoveva Yagüe; Zufiaurre, N. Gutiérrez; Muñoz‐Bellido, Juan Luis; Hernández, M. Segovia; Rodríguez, José Ángel García

doi:10.1016/s0924-8579(03)00121-3

Cited by 24 publications

(20 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of this study confirm previous studies by other authors on the occurrence of multidrug-resistant strains among C. striatum [6], C. amycolatum [17,44] and C. jeikeium [45]. …”

Section: Resultssupporting

confidence: 92%

Antibiotic Resistance and Detection of the Most Common Mechanism of Resistance (MLSB) of Opportunistic Corynebacterium

Olender¹

2013

Chemotherapy

View full text Add to dashboard Cite

Background: Determination of antibiotic resistance of opportunistic Corynebacterium colonizing the nose that cause infections and evaluation of the applicability of a simple method for detecting the most common constitutive-type resistance to macrolides, lincosamides and streptogramin B (MLSB). Methods: 70 isolates colonizing the nose and 70 clinical isolates of various infection sites were used and identified using APICoryne and 16S rRNA. Minimal inhibitory concentrations (MICs) were determined (Etest) for 12 antibiotics. MLSB was defined based on MIC, a simple method using two disks (erythromycin/clindamycin) and detection of the gene erm X (PCR). Results: There was a high percentage - in both groups at the same level - of strains with MLSB (88.5% colonizing the nose and 87.1% causing infections). Detection with the phenotypic method MLSB was confirmed genetically (erm X) in all cases. In both groups, a high percentage of resistance was found to trimethoprim/sulfamethoxazole (in both groups 71.4%), chloramphenicol (nose 44.2%/infections 37.1%), tetracycline (28 and 45.7%) and β-lactam antibiotics (18.5 and up to 32.8%). Conclusion: Differences in antibiotic resistance were found between strains colonizing the respiratory tract and various infections. Isolates from infections more frequently exhibited multidrug resistance. The possibility of using a simple method was confirmed for MLSB detection, which can be applied to determine drug resistance in routine microbiological diagnostics of infections caused by opportunistic Corynebacterium.

show abstract

“…The results of this study confirm previous studies by other authors on the occurrence of multidrug-resistant strains among C. striatum [6], C. amycolatum [17,44] and C. jeikeium [45]. …”

Section: Resultssupporting

confidence: 92%

Antibiotic Resistance and Detection of the Most Common Mechanism of Resistance (MLSB) of Opportunistic Corynebacterium

Olender¹

2013

Chemotherapy

View full text Add to dashboard Cite

show abstract

“…In the same way as the genuine corynebacteria, these bacterial genera have developed very important resistances that, for example, limit the possible use of macrolides and lincosamides in the context of infections attributable to these organisms [9]. Moreover, with the exception of T. otitidis, a microorganism whose role in chronic otitis is subject to controversy [15], and which is very sensitive to ␤-lactams and fluoroquinolones, the other two genera studied show important resistance to these groups of antibiotics.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the publication of well-documented cases of infections caused by coryneform bacteria has been continuous [3][4][5][6], and concern has grown about their sensitivity patterns-since many of them exhibit different degrees of resistance to commonly used antimicrobials such as the ␤-lactams, macrolides or fluoroquinolones [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

In vitro activity of linezolid and 12 other antimicrobials against coryneform bacteria

Gómez-Garcés

Alós

Tamayo

2007

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

“…Encrusting cystitis caused by C. urealyticum is treated by endoscopic removal of encrustations, acidification of the urinary tract, and treatment with appropriate antibiotics. A number of reports document resistance of C. urealyticum isolates to ampicillin, cephalothin, gentamicin, imipenem, tetracycline, ciprofloxacin, ofloxacin and sometimes to tetracycline, erythromycin, and rifampicin [250, 251]; however, most isolates were susceptible to synercid and linezolid [250]. …”

Section: Rare Emerging and Under-reported Gram-positive And Polymicmentioning

confidence: 99%

Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract

2016

View full text Add to dashboard Cite

Gram-positive bacteria are a common cause of urinary tract infection (UTI), particularly among individuals who are elderly, pregnant, or who have other risk factors for UTI. Here we review the epidemiology, virulence mechanisms, and host response to the most frequently isolated Gram-positive uropathogens: Staphylococcus saprophyticus, Enterococcus faecalis, and Streptococcus agalactiae. We also review several emerging, rare, misclassified, and otherwise underreported Gram-positive pathogens of the urinary tract including Aerococcus, Corynebacterium, Actinobaculum, and Gardnerella. The literature strongly suggests that urologic diseases involving Gram-positive bacteria may be easily overlooked due to limited culture-based assays typically utilized for urine in hospital microbiology laboratories. Some UTIs are polymicrobial in nature, often involving one or more Gram-positive bacteria. We herein review the risk factors and recent evidence for mechanisms of bacterial synergy in experimental models of polymicrobial UTI. Recent experimental data has demonstrated that, despite being cleared quickly from the bladder, some Gram-positive bacteria can impact pathogenic outcomes of co-infecting organisms. When taken together, the available evidence argues that Gram-positive bacteria are important uropathogens in their own right, but that some can be easily overlooked because they are missed by routine diagnostic methods. Finally, a growing body of evidence demonstrates that a surprising variety of fastidious Gram-positive bacteria may either reside in or be regularly exposed to the urinary tract and further suggests that their presence is widespread among women, as well as men. Experimental studies in this area are needed; however, there is a growing appreciation that the composition of bacteria found in the bladder could be a potentially important determinant in urologic disease, including susceptibility to UTI.

show abstract

In vitro activity of newer antibiotics against Corynebacterium jeikeium, Corynebacterium amycolatum and Corynebacterium urealyticum

Cited by 24 publications

References 15 publications

Antibiotic Resistance and Detection of the Most Common Mechanism of Resistance (MLSB) of Opportunistic Corynebacterium

Antibiotic Resistance and Detection of the Most Common Mechanism of Resistance (MLSB) of Opportunistic Corynebacterium

In vitro activity of linezolid and 12 other antimicrobials against coryneform bacteria

Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract

Contact Info

Product

Resources

About