In vitro activity of some medicinal plants from Cachar district, Assam (India) against Candida albicans

Abstract

Introduction: The current research has focused on the potentiality of medicinal plants for treatment of Candida albicans infections. Five plants viz. Clerodendron colebrookianum Walp. (Leaf), Gnetum gnemon L. (Leaf), Sarcochlamys pulcherrima (Roxb.) Gaud. (Leaf), Garcinia lancifolia (Don) Roxb (Leaf) and Euryale ferox Salisb. (Seed), used as traditional medicines in Cachar district, Assam, India were selected to evaluate in vitro activity against C. albicans. Methods: The plant samples were extracted with methanol. Agar well diffusion assay was used to test the activity of the plant extracts and broth microdilution method was used to determine the MIC. Results: All extracts showed anticandidial activity with zones of inhibition ranging from 17 to 25 mm at 2 × 10 5 µg/ml extract. E. ferox and S. pulcherrima showed the highest activity with the MIC value of 1.25 × 10 4 µg/ml. The remaining extracts were comparatively less effective showing MIC value of 2.5 × 10 4 µg/ml. Conclusions: Anticandidial activity of the plants extracts, observed in this study highlighted further in vivo investigation and identification of the active compounds for therapeutic uses. The anticandidial activity of S. pulcherrima and G. lancifolia is probably the first report to the best of our knowledge.

Antimicrobial activity of methanol extract and fractions from <i>Sarcochlamys pulcherrima</i>

“…It can be inferred that antimicrobial compounds are present mostly in ethyl acetate and n-butanol fractions, which might be medium polar to polar in nature. Similar obser -vations were also reported earlier in other medicinal plants (Teke et al, 2011;Das et al, 2010;Mazumder et al, 2012). Earlier in a study, higher range of antidermatophytic activity of hexane fraction of O. gratissimum leaves was reported (Silva et al, 2005).…”

Potent antifungal properties of gallic acid in Sarcochlamys pulcherrima against Candida auris

“…Previous studies have reported the antioxidant and antifungal properties of S. pulcherrima methanolic extract against C. albicans (Paul et al, 2010 ; Mazumder et al, 2012 ; Mazumder et al, 2014 ). However, the modes of action and efficacy of the extract against multidrug Candida spp.…”

Pharmaceutical scope of a phytochemically unexplored medicinal plant, Sarcochlamys pulcherrima (Roxb.) Gaud.: A review

“…In a subsequent study, we observed the potential activity of methanolic leaf extracts from S. pulcherrima in the inhibition of Candida albicans . [ 11 ]…”

“…S. pulcherrima is commonly known as dogal tree (English). It is known by different vernacular names among different tribes and communities, such as Mechaki/Mesaki/Meshangi (Assamese),[ 5 7 8 ] Ombe (Mising),[ 9 ] Ambe (Mishing), Adumbra (Bodo),[ 7 ] Notke (Mishing),[ 10 ] Khajathshear (Khasi),[ 11 ] and Mechaki (Garo). [ 6 ] In Bandarban district of Bangladesh, the plant is known as Ma Cha Da (Marma tribe), Kan Leng (Murang tribe), Jung Gallya sak (Tanchangya tribe),[ 12 ] and Jangaillya shak (Chakma tribe, Hill tract district, Bangladesh).…”