In Vitro Activity of Telithromycin against Macrolide-Susceptible and Macrolide-Resistant Pharyngeal Isolates of Group A Streptococci in the United States

Abstract

In vitro susceptibility testing of 2,797 group A streptococcus (GAS) isolates demonstrated that telithromycin was fully active against all macrolide-susceptible strains and among 80 of 115 macrolide-resistant GAS expressing the M phenotype. Telithromycin resistance was identified in 2 of 45 strains expressing the inducible macrolide-lincosamide-streptogramin B phenotype and four of nine isolates expressing the constitutive macrolide-lincosamide-streptogramin B resistance phenotype.

Hot Topics in Infection and Immunity in Children III

“…While intermittent increases in erythromycin resistance have occurred in many areas throughout the world (Green et al, 2005;Syrogianopoulos et al, 2001), they may be linked to increased, widespread use of macrolide-class antibiotics.…”