2010
DOI: 10.1007/s10096-010-0886-2
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In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains

Abstract: The in vitro activity of tigecycline was determined using a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 202), including 33 livestock-associated strains. Susceptibility testing was performed using the Etest system. Among the 202 MRSA strains, three (1.5%) had a minimum inhibitory concentration (MIC) value for tigecycline greater than 0.5 mg/l, which are considered to be resistant. When these strains were tested using Iso-Sensitest medium, the MICs were substantial… Show more

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Cited by 19 publications
(13 citation statements)
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“…Tigecycline resistance among staphylococci has been rarely reported in the literature (22). Despite the aforementioned fact, in our study 18.40% of isolates showed resistance to tigecycline which should be confirmed with other methods.…”
Section: Discussionsupporting
confidence: 47%
“…Tigecycline resistance among staphylococci has been rarely reported in the literature (22). Despite the aforementioned fact, in our study 18.40% of isolates showed resistance to tigecycline which should be confirmed with other methods.…”
Section: Discussionsupporting
confidence: 47%
“…Because the E test system has been reported to have O99% sensitivity and specificity to detect methicillin resistance, it has been widely used for the past 2 decades. 7,8 All findings were recorded into an electronic database. Point estimates and 95% confidence intervals were calculated using statistical software (Stata Version 7, Statacorp, College Station, TX).…”
Section: Methodsmentioning
confidence: 99%
“…In clinical daily routine tigecyclin shows good therapeutic efficacy against intraabdominal infection, skin- and soft-tissue infections [23,24]. Tigecyclin shows activity against infection caused by MRSA [25] and against biofilm associated pathogens [26]. Furthermore tigecyclin is absorbed by bone tissue after intravenous application [27].…”
Section: Introductionmentioning
confidence: 99%