In Vitro Adsorption-Desorption of Fluphenazine Dihydrochloride and Promethazine Hydrochloride by Microcrystalline Cellulose

Franz, Robert M.; Peckx, Garnet E.

doi:10.1002/jps.2600711103

Cited by 18 publications

(3 citation statements)

References 21 publications

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“…There are few drugs, e.g. ketotifen [13], ampicilline and amoxycilline [14], fluphenazine dihydrochloride and promehazine hydrochloride [15] have been investigated to find out the adsorption capacity of MCC.…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15]20] This is attributed to the reduction of the solubility of the drug with the increase in pH [13]. Franz and Peck suggested [15] that it is due to the ionization of carboxyl groups on the cellulose surface. When the pH values of the suspensions are increased, the number of negatively charged carboxylate groups on the surface of the MCC particles increases.…”

Section: Introductionmentioning

confidence: 99%

“…The increased number of anionic surface sites leads to increased adsorption of predominantly positively charged drugs at surface of particles. Franz and Peck also suggested that the possibility also excist that these hydrophobic drugs are adsorbed from solution as the nonprotonated free bases [15].…”

Section: Introductionmentioning

confidence: 99%

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Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres

Ashaduzzaman

Al-Rafin

Mustary

et al. 2016

IJPPE

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Abstract. Naturally engineered cellulosic fibres are of particular interest due to their diverse interfacial behavior; which could be well suited to operating interaction with functionalized drug. In the present work, interaction of Lidocaine (LC) hydrochloride, 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide was widely studied with cellulosic fibres i.e. cotton, jute and coir in presence of 0.1M HCl aqueous solution. In UV-Vis spectroscopy measurement, it is revealed that the highest interaction (adsorption 18 mg/g of fibres) of LC was occurred onto the cotton fibres surfaces from 3.5 mg/mL aqueous solution after 30 minutes gentle shaking. Kinetic studies in case of cotton fibres showed a linear relationship (R 2 = 0.9987) during desorption of LC upto 30 minutes at 25 o C temperature. The cotton fibres concentration was to be calculated 0.0085 g unit mol/L by considering the unit molecular weight of glucose unit. When 2.5 mg/mL (0.0108 g mol/L) LC drug solution was used then the ratio between glucose unit and LC drug was found to be 1.27. The interaction of LC was also increased direct-proportionally to the weight of cotton fibres. The resulting interaction phenomena of model LC would help us to deign dosage of anesthetic drug for specific physiological conditions.

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Section: Introductionmentioning

confidence: 99%