In vitro aerosol delivery by vibrating mesh nebulizer (VMN) and pressurized metered dose inhaler (pMDI) using spacers in comparison with T adapters in mechanical ventilation.

Eckes, Myriam; Paris, Alice; Hervieu, Brenda; Vanlaeys, Alison; Housseini, Karim; Porée, Thierry

doi:10.1183/23120541.rfmvc-2020.47

Cited by 3 publications

(2 citation statements)

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“…Consistent with previous studies, Boukhettala and colleagues [38] reported a three-fold increase in drug delivered using the CombiHaler with a pMDI in comparison to the MiniSpacer. A study by Eckles et al (2020) [39] also reported a two-or three-fold increase in drug delivery using a pMDI with a spacer instead of a pMDI adapter. For standard ventilation settings with active humidification, the pMDI/MiniSpacer delivered a larger dose (84.62 ± 8.97 µg) in comparison to the pMDI/F&P wye (56.92 ± 5.22 µg).…”

Section: Effect Of Pmdi Adapter Type On Drug Deliverymentioning

confidence: 98%

Evaluation of Aerosol Drug Delivery Options during Adult Mechanical Ventilation in the COVID-19 Era

et al. 2021

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Drug delivery devices used for aerosol therapy during mechanical ventilation to ease the symptoms of respiratory diseases provide beneficial treatment but can also pose challenges. Reflecting the significant changes in global guidance around aerosol usage and lung-protective ventilation strategies, seen in response to the COVID-19 pandemic, for the first time, we describe the drug delivery performance of commonly used devices under these conditions. Here, vibrating mesh nebuliser (VMN), jet nebuliser (JN) and pressurised metered-dose inhaler (pMDI) performance was assessed during simulated adult mechanical ventilation. Both standard test breathing patterns and those representatives of low tidal volume (LTV) ventilation with concurrent active and passive humidification were investigated. Drug delivery using a VMN was significantly greater than that with a JN and pMDI for both standard and LTV ventilation. Humidification type did not affect the delivered dose across all device types for standard ventilation. Significant variability in the pMDI dosing was evident, depending on the timing of actuation and the adapter type used. pMDI actuation synchronised with inspiration resulted in a higher delivered drug dose. The type of adapter used for pMDI actuation influenced drug delivery, with the highest dose observed using the CombiHaler.

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Section: Effect Of Pmdi Adapter Type On Drug Deliverymentioning

confidence: 98%

Evaluation of Aerosol Drug Delivery Options during Adult Mechanical Ventilation in the COVID-19 Era

et al. 2021

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“…de Charras et al [ 6 ] demonstrated that the design of the valve significantly influences the emitted fraction of salbutamol in cylindrical VHCs. Eckes et al [ 7 ] investigated the in vitro administration of salbutamol using a pMDI and an inhalation chamber without an inspiratory valve for neonatal patients, in comparison to conventional VHCs. The authors determined that the deposited mass when the holding chamber was used without an inspiratory valve was considerably greater than when the holding chamber including the valve was used, even without achieving correct synchronization of pMDI actuation and inhalation.…”

Section: Introductionmentioning

confidence: 99%

Aerosol deposition and emission from a United States Pharmacopeia‐induction port when using a pressurized metered‐dose inhaler with and without a valved holding chamber

de Charras,

Ramírez Rigo,

Bertin

2024

Can J Chem Eng

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The testing of pharmaceutical aerosols includes measuring the aerodynamic particle size distribution, which is usually performed on cascade impactors. In the next generation impactor (NGI), the aerosol dose is introduced through an induction port (IP), being separated into different aerodynamic diameter ranges by seven stages and a micro‐orifice collector. The IP plays an important role in estimating the oropharyngeal deposition fraction. While the IP retains mainly large particles, it also tends to retain particles in the respirable range. In this work, the deposition of particles in the IP of an NGI is studied, both experimentally and through computational fluid dynamic (CFD) simulations. Experimental tests are conducted both with the pressurized metered‐dose inhaler (pMDI) alone and in conjunction with a cylindrical valved holding chamber (VHC). For each case, the total mass deposition that occurs in the VHC, IP, and NGI stages is measured, as well as the mass median aerodynamic diameter of the aerosol leaving the IP. The CFD simulations show minimal variations in results regardless of the injection method due to the relatively low velocity and spray angle of the pMDI‐generated aerosol. If the flap‐valve is removed from the VHC, significant particle deposition occurs upstream or within the valve region, with downstream air recirculation contributing to small particle deposition. Based on the CFD results, a correlation is proposed to accurately predict the particle escape fraction of the IP and VHC, which allows estimation of the tannin distribution of particles collected in the NGI stages, especially those corresponding to the range of respirable particles.

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Preliminary bronchodilator dose effect on aerosol-delivery through different nebulizers in noninvasively ventilated COPD patients

Madney

Harb

Porée³

et al. 2022

Experimental Lung Research

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In vitro aerosol delivery by vibrating mesh nebulizer (VMN) and pressurized metered dose inhaler (pMDI) using spacers in comparison with T adapters in mechanical ventilation.

Cited by 3 publications

References 0 publications

Evaluation of Aerosol Drug Delivery Options during Adult Mechanical Ventilation in the COVID-19 Era

Evaluation of Aerosol Drug Delivery Options during Adult Mechanical Ventilation in the COVID-19 Era

Aerosol deposition and emission from a United States Pharmacopeia‐induction port when using a pressurized metered‐dose inhaler with and without a valved holding chamber

Preliminary bronchodilator dose effect on aerosol-delivery through different nebulizers in noninvasively ventilated COPD patients

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