In Vitro Amoebicidal Activity of Imidazolium Salts Against Trophozoites

Fabres, Laura Fuhrich; Gonçalves, Fabiany da Costa; Duarte, Eliane Oliveira Salines; Berte, Francisco Kercher; Conceição, Débora Kélen Si Lva da; Ferreira, Leonildo Alves; Schrekker, Henri Stephan; Rott, Marilise Brittes

doi:10.2478/s11686-019-00161-6

Cited by 5 publications

(7 citation statements)

References 55 publications

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“…109 The cationic derivatives of IS have promising potential in the development of antimicrobials. 81 Due to a large number of biological activities, Fabres et al, 81 assessed the amoebicidal activity of four imidazolium salts compounds, that is, compounds 24, 25, 26, and 27 (Tables 2 and 3 for more detail). Acanthamoeba castellanii used in this assay were isolated clinically, belonging to a T4 genotype and environmental strain.…”

Section: Imidazolium Salts (Is)mentioning

confidence: 99%

“…The study also demonstrated that, these compounds inhibit the encystment of trophozoites and no cyst was seen after the treatment with these compounds. 81 An in vivo investigation is required to evaluate the toxicity of these compounds to cornea as well as their promising potential to be used in disinfecting solutions or as an ingredient of lens cleaning solution. 81…”

Section: Imidazolium Salts (Is)mentioning

confidence: 99%

“…81 An in vivo investigation is required to evaluate the toxicity of these compounds to cornea as well as their promising potential to be used in disinfecting solutions or as an ingredient of lens cleaning solution. 81…”

Section: Imidazolium Salts (Is)mentioning

confidence: 99%

“…Antiarrhythmic activity is one of the potential biological activity which has been reported for these salts, while the other biological activities are antimicrobial, 104 antifungal, 105,106 antiparasitic, 107 antiinflammatory, 108 and larvicidal 109 . The cationic derivatives of IS have promising potential in the development of antimicrobials 81 …”

Section: Medicinal Chemistry Approach For Drug Discovery Against Acan...mentioning

confidence: 99%

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Applications of medicinal chemistry for drug discovery against Acanthamoeba infections

Ahmed

Anwar

Ong

et al. 2021

Medicinal Research Reviews

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Acanthamoeba is a genus of free‐living amoebae, pervasively found in the environment. Most of its pathogenic species are the causative agent of sight‐threatening Acanthamoeba keratitis and fatal granulomatous amoebic encephalitis. Despite the advancements in the field of chemotherapy, treating Acanthamoeba infections is still challenging due to incomplete knowledge of the complicated pathophysiology. In case of infection, the treatment regimen for the patients is often ineffective due to delayed diagnosis, poor specificity, and side‐effects. Besides the resistance of Acanthamoeba cysts to most of the drugs, the recurrence of infection further complicates the recovery. Thus, it is necessary to develop an effective treatment which can eradicate these rare, but serious infections. Based on various computational and in vitro studies, it has been established that the synthetic scaffolds such as heterocyclic compounds may act as potential drug leads for the development of antiamoebic drugs. In this review, we report different classes of synthetic compounds especially heterocyclic compounds which have shown promising results against Acanthamoeba. Moreover, the antiamoebic activities of synthetic compounds with their possible mode of actions against Acanthamoeba, have been summarized and discussed in this review.

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Section: Imidazolium Salts (Is)mentioning

confidence: 99%

Section: Imidazolium Salts (Is)mentioning

confidence: 99%

Section: Imidazolium Salts (Is)mentioning

confidence: 99%

Section: Medicinal Chemistry Approach For Drug Discovery Against Acan...mentioning

confidence: 99%

See 2 more Smart Citations

Applications of medicinal chemistry for drug discovery against Acanthamoeba infections

Ahmed

Anwar

Ong

et al. 2021

Medicinal Research Reviews

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“… 74 , 75 The effectiveness of contact lens multipurpose solutions against Acanthamoeba , a topic debated by the FLA community, 76 has been also investigated in Brazil, 77 , 78 including the suggestion of imidazolium salt, an anti-amoebic substance, as a suitable option for lens storage. 79 Alternatively, therapeutic strategies were concerned with molecules essential to cell division, energy production, cell differentiation, or movement. Examples consist of two Brazilian studies testing the role of small interfering RNA (siRNA) carried in liposomes as an anti-amoebic agent by in vitro and in vivo assays.…”

mentioning

confidence: 99%

A history of over 40 years of potentially pathogenic free-living amoeba studies in Brazil - a systematic review

Bellini

Thiemann

Reyes-Batllé

et al. 2022

Mem. Inst. Oswaldo Cruz

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Free-living amoeba (FLA) group includes the potentially pathogenic genera Acanthamoeba, Naegleria, Balamuthia, Sappinia, and Vermamoeba, causative agents of human infections (encephalitis, keratitis, and disseminated diseases). In Brazil, the first report on pathogenic FLA was published in the 70s and showed meningoencephalitis caused by Naegleria spp. FLA studies are emerging, but no literature review is available to investigate this trend in Brazil critically. Thus, the present work aims to integrate and discuss these data. Scopus, PubMed, and Web of Science were searched, retrieving studies from 1974 to 2020. The screening process resulted in 178 papers, which were clustered into core and auxiliary classes and sorted into five categories: wet-bench studies, dry-bench studies, clinical reports, environmental identifications, and literature reviews. The papers dating from the last ten years account for 75% (134/178) of the total publications, indicating the FLA topic has gained Brazilian interest. Moreover, 81% (144/178) address Acanthamoeba-related matter, revealing this genus as the most prevalent in all categories. Brazil's Southeast, South, and Midwest geographic regions accounted for 96% (171/178) of the publications studied in the present work. To the best of our knowledge, this review is the pioneer in summarising the FLA research history in Brazil.

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Enhanced cytocompatible gelatin/chondroitin sulfate/ionic liquid polyelectrolyte multilayers with virucidal activity against mouse hepatitis coronavirus

Souza,

Freitas,

Tsukamotoe

et al. 2024

Journal of Molecular Liquids

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In Vitro Amoebicidal Activity of Imidazolium Salts Against Trophozoites

Cited by 5 publications

References 55 publications

Applications of medicinal chemistry for drug discovery against Acanthamoeba infections

Applications of medicinal chemistry for drug discovery against Acanthamoeba infections

A history of over 40 years of potentially pathogenic free-living amoeba studies in Brazil - a systematic review

Enhanced cytocompatible gelatin/chondroitin sulfate/ionic liquid polyelectrolyte multilayers with virucidal activity against mouse hepatitis coronavirus

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