In-Vitro Analysis for Microbial Barrier Properties of 2-Octyl Cyanoacrylate-Derived Wound Treatment Films

Narang, Upvan; Mainwaring, Lawrence; Spath, Gina; Barefoot, Joe

doi:10.1007/s10227-002-1155-5

Cited by 34 publications

(20 citation statements)

References 13 publications

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“…The two most common complications of circumcision are bleeding and wound infection. [2] The cyanoacrylate tissue glue has been claimed to have the advantages of being hemostatic,[3] bacteriostatic[45] and easy to use.…”

Section: Introductionmentioning

confidence: 99%

Sutureless circumcision - An Indian experience

Tiwari

Kumar

et al. 2011

Indian J Urol

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Context:Traditionally, circumcision wounds are closed by absorbable sutures. However, certain alternative methods are also being utilized to overcome the shortcomings of the conventionally used method for circumcision wound closuring. In the current study, the use of tissue glue ((iso amyl 2-cyanoacrylate) has been compared with traditional suturing for the approximation of circumcision wounds. In our study, both the methods were found to be comparable with significantly less time consumed in glue group.Aims:The purpose of the present study has been to compare directly cyanoacrylate as a better alternative to conventional suture material in terms of cosmetic result, time consumed and incidence of infection (comparative study).Materials and Methods:The results of all the patients seen in outpatient department for circumcision were included in this study. The study was conducted from Aug 2009 to May 2010. The tissue glue (iso amyl 2-cyanoacrylate) was compared to sutures as a method of wound approximation in circumcision.Results:Tissue glue group has been observed to have less wound inflammation, bleeding or hematoma rate and was cosmetically superior as compared to suture group; however, none of these findings could reach statistically significant level. The mean time taken for circumcision was 14.2 min (SD 2.42), when tissue glue was used for wound approximation. However, it was 24.4 min (SD 5.06) in case of the use of sutures. This difference was found as highly significant (P value < 0.001). However, regarding postoperative pain no significant reduction was observed when glue was used.Conclusions:This study showed that the use of tissue glue in comparison to sutures is having the following advantages: Cosmetically superiorLess time consuming All other parameters measured were nearly the same and statically insignificant.

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Section: Introductionmentioning

confidence: 99%

Sutureless circumcision - An Indian experience

Tiwari

Kumar

et al. 2011

Indian J Urol

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“…This makes cyanoacrylate an excellent alternative, not only as suture replacement but also to prevent infection. [15] Cyanoacrylate can also be used in the form of bandages as they have occlusive dressing properties; the rapid hemostatic effect is probably by sealing cuts and leaky vessels. In this regard, Histoacryl, when used as a topical adhesive overapproximated wound edges, is an effective and easily applicable local hemostatic for oral surgery in such patients.…”

Section: Resultsmentioning

confidence: 99%

Unilateral cleft lip closure by use of Dermabond (N-octyle-2-cyanoacrylate)

Mishra¹,

Shukla²,

Sahu³

et al. 2020

ijmsci

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Background: Facial cosmetic results are one of the most concerning issues for the parents who get their children operated for cleft lip. Moreover, the postoperative care of the surgical site, the discomfort associated with the suture removal, and additional visit for suture removal are other reasons which encourages one to use any new technologies that may replace the need for suture placement. In this study, we used octyl-2-cyanoacrylate, a tissue adhesive which offers a viable alternative to traditional techniques without compromising optimal wound closure. Objective: To perform a comprehensive comparison of the outcomes from the use of Dermabond in patients undergoing primary repair of congenital cleft lip ± palate anomalies. Materials and Methods: Twenty patients, in the age group of 3–18 months were treated surgically for unilateral cleft lip deformity using Millard rotation-advancement flap. Pre- and post-operative photographs of the patients were taken at 1 week, 2 week, 1 month, 6 months, and 1 year postoperatively and were evaluated using Vancouver scar scale which was given by Sullivan in 1990. Paired t-test was used for statistical analysis. Results: Increased vascularity (hyperemia) was seen in the 1st and 2nd week in 35% and 30% patients, respectively which gradually reduced to normal in subsequent follow-ups. The scar was flat in 85% of patients in 1st week, and the number decreased to 10% at the end of 1 year. No wound dehiscence was found in any patients. Statistical analysis showed that among all the follow-ups, only the difference between the first and second follow-ups. Comparison of the results of 1 week with all other follow-ups yielded no significant results. Conclusion: Octyl-2-cyanoacrylate can be used for cleft lip closure effectively. The procedure is relatively painless and quick. Added to this are benefits of protection from wound infection since the material is bacteriostatic.

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“…10 In vitro studies have shown that octyl-2-cyanoacrylate is capable of acting as a barrier against infectious organisms, in addition to presenting antibacterial and hemostatic properties. 6,[11][12][13] Borley and Mortensen and Rajimwale and colleagues successfully used octyl-2-cyanoacrylate as a dressing over sutured abdominal and urologic wounds. 14,15 To our knowledge, its use as an occlusive dressing over sutured facial excisions has never been previously reported.…”

Section: Discussionmentioning

confidence: 97%