In vitro analysis of particle penetration of smokeless tobacco forms using egg shell membrane as a substrate

Jagannathan, Nithya; Manian, Abilasha Ramasubra; Ramani, Pratibha; Premkumar, Priya; Natesan, Anuja; Sherlin, Herald J

doi:10.4103/0973-1482.138098

Cited by 4 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are several hypotheses brought in literature regarding possible connection between smoking habits and oral Candida: mucosal changes effecting the colonization of candida [9], pro-candidal factors found in tobacco [13], the correlation between acidification of saliva (caused in part by smoking) and carriage state of candida [2] There exists a strong relationship between the tobacco particle size and tobacco related cancer and potentially malignant disorders. Over the past decades, numerous studies have been done to analyze the effect of chemical composition of these products on oral mucosa [53]. In a study done by Naziya K.B et al among dental students revealed that the mean knowledge score among males and females was 24 and 23.9, respectively.…”

Section: Discussionmentioning

confidence: 99%

Association Between Smoking and Smokeless from of Tobacco With candida Species in The Oral Cavity.

Elumalai¹

2023

IJOFB

View full text Add to dashboard Cite

Candida species constitute a part of the human oral commensal flora in 2 to 71 percent of healthy subjects. Several previous studies have reported that tobacco smoking, either alone or in combination with other systemic or local factors, is associated with increased oral candidal colonization or with the development of oral candidosis. It has been suggested that cigarette smoking might lead to localized epithelial alterations allowing candidal colonization. Cigarette smoke may also provide nutrition for candida albicans. Theories offer partial explanations why smokers may be more prone to candidal leukoplakia with higher potential for malignant changes than other leukoplakias. Aim of the study was to assess and compare the quantitative oral colonization of Candida species between a group of tobacco smokers and smokeless form of tobacco users

show abstract

Section: Discussionmentioning

confidence: 99%

Association Between Smoking and Smokeless from of Tobacco With candida Species in The Oral Cavity.

Elumalai¹

2023

IJOFB

View full text Add to dashboard Cite

show abstract

“…The results of our study can be correlated to several studies wherein the prevalence of potentially malignant disorders and oral squamous cell carcinoma were assessed in smokeless tobacco users [ 18 ]. A review of literature on various smokeless tobacco products in potentially malignant and malignant disorders demonstrated a greater prevalence of OSMF in gutka and mawa users and leukoplakia, erythroplakia and malignancies in tobacco leaf chewers [ 19 ] This could be due to the release of nitrosamines and other carcinogens from the tobacco leaf which could have a synergistic action on the particle size of the tobacco products [ 20 ]. Though khaini, having the smallest particle size has greatest association with OSMF compared with other forms, the number of studies done with khaini is comparatively less probably due to the late emergence of these products in 1990's.…”

Section: Discussionmentioning

confidence: 99%

Particle size, penetration rate and effects of smoke and smokeless tobacco products – an invitro analysis

Antony

Ramani

Ramasubramanian

et al. 2021

Heliyon

Self Cite

View full text Add to dashboard Cite

Utilization of tobacco products is a global epidemic that causes a health threat among the adolescents and adults of the world. If the current pattern perpetuates, it is estimated to cause 10 million deaths each year by 2020. According to the 2009–2010 survey by Global Adult Tobacco Survey, 53.5% of Indians use tobacco products (66.2% of men and 40% of women). Cancers of the lip and oral cavity are highly frequent in Southern Asia (eg: India and Sri Lanka) and it is also the leading cause of cancer death among men in India and Sri Lanka. Aim and objectives The aim of the study is to evaluate the particle size, and assess the penetration rate in egg shell membrane and proliferation rate using cell lines among 4 commercially available tobacco products. Materials and methods A total of 4 tobacco product samples namely Gutka, Khaini, Beedi and Cigarette was used to analyse the particle size using High resolution Scanning electron microscopy, the penetration rate on egg shell membrane using Spectroflurometry and proliferative rate using ELISA on cell lines respectively. Results Khaini revealed the smallest particle size and highest penetration and proliferation rate compared to Gutka, Beedi and Cigarette. Conclusion Current evidence shows that individuals who consume Khaini are at high risk to develop potentially malignant disorders and oral squamous cell carcinoma when compared to Gutka, Beedi and Cigarette (in the order of occurrence).

show abstract

The effect of cut sizes and pH of tobacco leaf in smokeless tobacco products on the pharmacokinetics of nicotine

Fu,

Wang,

et al. 2024

Drug and Chemical Toxicology

View full text Add to dashboard Cite

In vitro analysis of particle penetration of smokeless tobacco forms using egg shell membrane as a substrate

Abstract: The degree of diffusion gradually increased with a decrease in the particle size establishing an inverse relationship.

Cited by 4 publications

References 25 publications

Association Between Smoking and Smokeless from of Tobacco With candida Species in The Oral Cavity.

Association Between Smoking and Smokeless from of Tobacco With candida Species in The Oral Cavity.

Particle size, penetration rate and effects of smoke and smokeless tobacco products – an invitro analysis

The effect of cut sizes and pH of tobacco leaf in smokeless tobacco products on the pharmacokinetics of nicotine

Contact Info

Product

Resources

About